Spatial and Temporal Organization of the Individual Human Cerebellum
43 Pages Posted: 6 Jun 2018 Publication Status: PublishedMore...
The cerebellum contains the majority of neurons in the human brain and is unique for its uniform cytoarchitecture, absence of aerobic glycolysis, and role in adaptive plasticity. Despite anatomical and physiological differences between the cerebellum and cerebral cortex, group-average functional connectivity studies have identified networks related to specific functions in both structures. Recently, precision functional mapping of individuals revealed that functional networks in the cerebral cortex exhibit individual-specific topography. Using the highly-sampled Midnight Scan Club (MSC) dataset, we found the cerebellum contains reliable, individual-specific network organization that is significantly more variable than the cerebral cortex. The frontoparietal network, thought to support adaptive control, was the only network overrepresented in the cerebellum compared to the cerebral cortex (2.3-fold). Temporally, all cerebellar resting state signals lagged behind the cerebral cortex (125-380ms), most prominently within association networks. Our findings suggest a domain-general cerebellar function may be ultimate correction of all cortical motor and cognitive processes.
Keywords: fMRI; Human cerebellum; brain networks; individual variability; resting state functional connectivity; frontoparietal network; infra-slow activity; temporal lags
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