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Spatial and Temporal Organization of the Individual Human Cerebellum

43 Pages Posted: 6 Jun 2018 Sneak Peek Status: Published

See all articles by Scott Marek

Scott Marek

Washington University in St. Louis - Department of Neurology

Joshua S. Siegel

Washington University in St. Louis - Department of Neurology

Evan M. Gordon

Government of the United States of America - VISN 17 Center of Excellence for Research on Returning War Veterans; University of Texas at Dallas - Center for Vital Longevity; Baylor University - Department of Psychology and Neuroscience

Ryan V. Raut

Washington University in St. Louis - Mallinckrodt Institute of Radiology

Caterina Gratton

Washington University in St. Louis - Department of Neurology

Dillan J. Newbold

Washington University in St. Louis - Department of Neurology

Mario Ortega

Washington University in St. Louis - Department of Neurology

Timothy O. Laumann

Washington University in St. Louis - Department of Neurology

Derek B. Miller

Washington University in St. Louis - Department of Neurology

Annie Zheng

Washington University in St. Louis - Department of Neurology

Katherine C. Lopez

Washington University in St. Louis - Department of Psychological and Brain Sciences

Jeffrey J. Berg

New York University (NYU) - Department of Psychology

Rebecca S. Coalson

Washington University in St. Louis - Department of Neurology; Washington University in St. Louis - Mallinckrodt Institute of Radiology

Annie L. Nguyen

Washington University in St. Louis - Department of Neurology

Donna Dierker

Washington University in St. Louis - Mallinckrodt Institute of Radiology

Andrew N. Van

Washington University in St. Louis - Department of Neurology

Catherine R. Hoyt

Washington University in St. Louis - Program in Occupational Therapy

Kathleen B. McDermott

Washington University in St. Louis - Department of Psychological and Brain Sciences; Washington University in St. Louis - Mallinckrodt Institute of Radiology

Scott A. Norris

Washington University in St. Louis - Department of Neurology

Joshua S. Shimony

Washington University in St. Louis - Mallinckrodt Institute of Radiology

Abraham Z. Snyder

Washington University in St. Louis - Department of Neurology; Washington University in St. Louis - Mallinckrodt Institute of Radiology

Steven M. Nelson

Government of the United States of America - VISN 17 Center of Excellence for Research on Returning War Veterans; University of Texas at Dallas - Center for Vital Longevity; Baylor University - Department of Psychology and Neuroscience

Deanna M. Barch

Washington University in St. Louis - Department of Psychological and Brain Sciences; Washington University in St. Louis - Mallinckrodt Institute of Radiology; Washington University in St. Louis - Department of Psychiatry

Bradley L. Schlaggar

Washington University in St. Louis - Department of Neurology; Washington University in St. Louis - Mallinckrodt Institute of Radiology; Washington University in St. Louis - Department of Radiology; (Formerly Department of Anatomy and Neurobiology; Washington University in St. Louis - Department of Pediatrics; Washington University in St. Louis - Department of Psychiatry

Marcus E. Raichle

Washington University in St. Louis - Department of Neurology; Washington University in St. Louis - Mallinckrodt Institute of Radiology; Washington University in St. Louis - Department of Biomedical Engineering; (Formerly Department of Anatomy and Neurobiology

Steven E. Petersen

Washington University in St. Louis - Department of Neurology; Washington University in St. Louis - Department of Psychological and Brain Sciences; Washington University in St. Louis - Mallinckrodt Institute of Radiology; (Formerly Department of Anatomy and Neurobiology; Washington University in St. Louis - Department of Biomedical Engineering; Washington University in St. Louis - Department of Neurosurgery

Deanna J. Greene

Washington University in St. Louis - Department of Radiology; Washington University in St. Louis - Mallinckrodt Institute of Radiology; Washington University in St. Louis - Department of Psychiatry

Nico U.F. Dosenbach

Washington University in St. Louis - Department of Neurology; Washington University in St. Louis - Program in Occupational Therapy; Washington University in St. Louis - Mallinckrodt Institute of Radiology; Washington University in St. Louis - Department of Pediatrics; Washington University in St. Louis - Department of Biomedical Engineering

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Abstract

The cerebellum contains the majority of neurons in the human brain and is unique for its uniform cytoarchitecture, absence of aerobic glycolysis, and role in adaptive plasticity. Despite anatomical and physiological differences between the cerebellum and cerebral cortex, group-average functional connectivity studies have identified networks related to specific functions in both structures. Recently, precision functional mapping of individuals revealed that functional networks in the cerebral cortex exhibit individual-specific topography. Using the highly-sampled Midnight Scan Club (MSC) dataset, we found the cerebellum contains reliable, individual-specific network organization that is significantly more variable than the cerebral cortex. The frontoparietal network, thought to support adaptive control, was the only network overrepresented in the cerebellum compared to the cerebral cortex (2.3-fold). Temporally, all cerebellar resting state signals lagged behind the cerebral cortex (125-380ms), most prominently within association networks. Our findings suggest a domain-general cerebellar function may be ultimate correction of all cortical motor and cognitive processes.

Keywords: fMRI; Human cerebellum; brain networks; individual variability; resting state functional connectivity; frontoparietal network; infra-slow activity; temporal lags

Suggested Citation

Marek, Scott and Siegel, Joshua S. and Gordon, Evan M. and Raut, Ryan V. and Gratton, Caterina and Newbold, Dillan J. and Ortega, Mario and Laumann, Timothy O. and Miller, Derek B. and Zheng, Annie and Lopez, Katherine C. and Berg, Jeffrey J. and Coalson, Rebecca S. and Nguyen, Annie L. and Dierker, Donna and Van, Andrew N. and Hoyt, Catherine R. and McDermott, Kathleen B. and Norris, Scott A. and Shimony, Joshua S. and Snyder, Abraham Z. and Nelson, Steven M. and Barch, Deanna M. and Schlaggar, Bradley L. and Raichle, Marcus E. and Petersen, Steven E. and Greene, Deanna J. and Dosenbach, Nico U.F., Spatial and Temporal Organization of the Individual Human Cerebellum (2018). Available at SSRN: https://ssrn.com/abstract=3188429 or http://dx.doi.org/10.2139/ssrn.3188429
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Scott Marek (Contact Author)

Washington University in St. Louis - Department of Neurology ( email )

St. Louis, MO
United States

Joshua S. Siegel

Washington University in St. Louis - Department of Neurology

St. Louis, MO
United States

Evan M. Gordon

Government of the United States of America - VISN 17 Center of Excellence for Research on Returning War Veterans ( email )

Doris Miller VA Medical Center
4800 Memorial Drive (151C)
Waco, TX 76711
United States

University of Texas at Dallas - Center for Vital Longevity ( email )

1600 Viceroy Drive Suit 800
Dallas, TX 75235
United States

Baylor University - Department of Psychology and Neuroscience ( email )

One Bear Place 97334
Waco, TX 76798-7334
United States

Ryan V. Raut

Washington University in St. Louis - Mallinckrodt Institute of Radiology

St. Louis, MO
United States

Caterina Gratton

Washington University in St. Louis - Department of Neurology

St. Louis, MO
United States

Dillan J. Newbold

Washington University in St. Louis - Department of Neurology

St. Louis, MO
United States

Mario Ortega

Washington University in St. Louis - Department of Neurology

St. Louis, MO
United States

Timothy O. Laumann

Washington University in St. Louis - Department of Neurology

St. Louis, MO
United States

Derek B. Miller

Washington University in St. Louis - Department of Neurology

St. Louis, MO
United States

Annie Zheng

Washington University in St. Louis - Department of Neurology

St. Louis, MO
United States

Katherine C. Lopez

Washington University in St. Louis - Department of Psychological and Brain Sciences

1 Brookings Drive
St. Louis, MO 63130
United States

Jeffrey J. Berg

New York University (NYU) - Department of Psychology

New York, NY 10003
United States

Rebecca S. Coalson

Washington University in St. Louis - Department of Neurology

St. Louis, MO
United States

Washington University in St. Louis - Mallinckrodt Institute of Radiology

St. Louis, MO
United States

Annie L. Nguyen

Washington University in St. Louis - Department of Neurology

St. Louis, MO
United States

Donna Dierker

Washington University in St. Louis - Mallinckrodt Institute of Radiology

St. Louis, MO
United States

Andrew N. Van

Washington University in St. Louis - Department of Neurology

St. Louis, MO
United States

Catherine R. Hoyt

Washington University in St. Louis - Program in Occupational Therapy

4444 Forest Park Ave.
St. Louis, MO 63108
United States

Kathleen B. McDermott

Washington University in St. Louis - Department of Psychological and Brain Sciences

1 Brookings Drive
St. Louis, MO 63130
United States

Washington University in St. Louis - Mallinckrodt Institute of Radiology

St. Louis, MO
United States

Scott A. Norris

Washington University in St. Louis - Department of Neurology

St. Louis, MO
United States

Joshua S. Shimony

Washington University in St. Louis - Mallinckrodt Institute of Radiology

St. Louis, MO
United States

Abraham Z. Snyder

Washington University in St. Louis - Department of Neurology

St. Louis, MO
United States

Washington University in St. Louis - Mallinckrodt Institute of Radiology

St. Louis, MO
United States

Steven M. Nelson

Government of the United States of America - VISN 17 Center of Excellence for Research on Returning War Veterans

Doris Miller VA Medical Center
4800 Memorial Drive (151C)
Waco, TX 76711
United States

University of Texas at Dallas - Center for Vital Longevity

1600 Viceroy Drive Suit 800
Dallas, TX 75235
United States

Baylor University - Department of Psychology and Neuroscience

One Bear Place 97334
Waco, TX 76798-7334
United States

Deanna M. Barch

Washington University in St. Louis - Department of Psychological and Brain Sciences

1 Brookings Drive
St. Louis, MO 63130
United States

Washington University in St. Louis - Mallinckrodt Institute of Radiology

St. Louis, MO
United States

Washington University in St. Louis - Department of Psychiatry

660 S. Euclid Avenue
St. Louis, MO 63110
United States

Bradley L. Schlaggar

Washington University in St. Louis - Department of Neurology

St. Louis, MO
United States

Washington University in St. Louis - Mallinckrodt Institute of Radiology

St. Louis, MO
United States

Washington University in St. Louis - Department of Radiology

3635 Vista Blvd.
St. Louis, MO 63110
United States

(Formerly Department of Anatomy and Neurobiology

One Brookings Drive
St. Louis, MO 63130
United States

Washington University in St. Louis - Department of Pediatrics

660 South Euclid Avenue
Campus Box 8208
St. Louis, MO 63130
United States

Washington University in St. Louis - Department of Psychiatry

660 S. Euclid Avenue
St. Louis, MO 63110
United States

Marcus E. Raichle

Washington University in St. Louis - Department of Neurology ( email )

St. Louis, MO
United States

Washington University in St. Louis - Mallinckrodt Institute of Radiology ( email )

St. Louis, MO
United States

Washington University in St. Louis - Department of Biomedical Engineering ( email )

One Brookings Drive
Campus Box 1208
Saint Louis, MO 63130-4899
United States

(Formerly Department of Anatomy and Neurobiology ( email )

One Brookings Drive
St. Louis, MO 63130
United States

Steven E. Petersen

Washington University in St. Louis - Department of Neurology

St. Louis, MO
United States

Washington University in St. Louis - Department of Psychological and Brain Sciences

1 Brookings Drive
St. Louis, MO 63130
United States

Washington University in St. Louis - Mallinckrodt Institute of Radiology

St. Louis, MO
United States

(Formerly Department of Anatomy and Neurobiology

One Brookings Drive
St. Louis, MO 63130
United States

Washington University in St. Louis - Department of Biomedical Engineering

One Brookings Drive
Campus Box 1208
Saint Louis, MO 63130-4899
United States

Washington University in St. Louis - Department of Neurosurgery

660 S. Euclid Ave., CB 8057
St. Louis, MO 63110
United States

Deanna J. Greene

Washington University in St. Louis - Department of Radiology

3635 Vista Blvd.
St. Louis, MO 63110
United States

Washington University in St. Louis - Mallinckrodt Institute of Radiology

St. Louis, MO
United States

Washington University in St. Louis - Department of Psychiatry

660 S. Euclid Avenue
St. Louis, MO 63110
United States

Nico U.F. Dosenbach

Washington University in St. Louis - Department of Neurology

St. Louis, MO
United States

Washington University in St. Louis - Program in Occupational Therapy

4444 Forest Park Ave.
St. Louis, MO 63108
United States

Washington University in St. Louis - Mallinckrodt Institute of Radiology

St. Louis, MO
United States

Washington University in St. Louis - Department of Pediatrics

660 South Euclid Avenue
Campus Box 8208
St. Louis, MO 63130
United States

Washington University in St. Louis - Department of Biomedical Engineering

One Brookings Drive
Campus Box 1208
Saint Louis, MO 63130-4899
United States

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