Cellular and Molecular Signalling Mechanisms in Neuronal Injury and Neurodegeneration

8 Pages Posted: 19 Jun 2018

See all articles by Swaroopa Maralla

Swaroopa Maralla

Sri Padmavati Mahila Visvavidyalayam (SPMVV) - Department of Sericulture

D. Bharathi

Sri Padmavati Mahila Visvavidyalayam (SPMVV) - Department of Sericulture

Date Written: February 7, 2018

Abstract

Neurodegenerative diseases are progressive neurological disorders characterized by death of specific nerve cells, excluding conditions such as ischemia, infection, intoxication, and malignant tumors. While redox imbalance contributes to neural injury, there are also other important crosstalk mechanisms. Despite extensive research, the cause of the neurodisease is unknown in the majority of cases, where as the mechanisms of motor neuron injury are complex and incompletely understood. The mechanistic underpinnings of calcium dysregulation resulting in calpain activation in the acute neurodegenerative diseases such as cerebral ischemia and in the chronic neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis etc include, oxidative stress, excitotoxicity caused by aberrant glutamate signalling, mitochondrial dysfunction and disruption of the neurofilament network. A better understanding of the mechanisms underlying neurodegeneration should lead to more effective disease-modifying treatments in the future.

Keywords: Alzheimer's disease, Huntington's disease, Ischemia, Multiple sclerosis, Neurodegeneration and Parkinson's disease

Suggested Citation

Maralla, Swaroopa and Bharathi, D., Cellular and Molecular Signalling Mechanisms in Neuronal Injury and Neurodegeneration (February 7, 2018). Sri Padmavati Mahila Visvavidyalayam (SPMVV), 2018 IADS International Conference on Computing, Communications & Data Engineering (CCODE) 7-8 February, Available at SSRN: https://ssrn.com/abstract=3197078 or http://dx.doi.org/10.2139/ssrn.3197078

Swaroopa Maralla (Contact Author)

Sri Padmavati Mahila Visvavidyalayam (SPMVV) - Department of Sericulture ( email )

Tirupati
India

D. Bharathi

Sri Padmavati Mahila Visvavidyalayam (SPMVV) - Department of Sericulture ( email )

Tirupati
India

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