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Incidental Findings on Brain MRI Among Chinese at the Age of 55-65 Years: The Taizhou Imaging Study

34 Pages Posted: 29 Aug 2018

See all articles by Shuyuan Li

Shuyuan Li

Shanghai Jiao Tong University (SJTU) - International Peace Maternity and Child Health Hospital

Fang Fang

Karolinska Institutet - Department of Medical Epidemiology and Biostatistics

Mei Cui

Fudan University - Department of Neurology

Yanfeng Jiang

Fudan University - Collaborative Innovation Center for Genetics and Development; Fudan University - State Key Laboratory of Genetic Engineering; Fudan University - Taizhou Institute of Health Sciences

Yingzhe Wang

Fudan University - Huashan Hospital

Xuhui Kong

Nantong University - Taizhou People's Hospital

Weizhong Tian

Nantong University - Taizhou People's Hospital

Min Fan

Taixing Disease Control and Prevention Center

Ziyu Yuan

Fudan University - Taizhou Institute of Health Sciences

Jinhua Chen

Nantong University - Taizhou People's Hospital

Qi Yang

Fudan University - Huashan Hospital

Fuzhong Xue

Fudan University; Shandong University

Jiucun Wang

Fudan University; Fudan University - Collaborative Innovation Center for Genetics and Development

Ming Lu

Shandong University - Clinical Epidemiology Unit

Xiaofeng Wang

Fudan University - Collaborative Innovation Center for Genetics and Development

Xingdong Chen

Fudan University - State Key Laboratory of Genetic Engineering; Fudan University - Collaborative Innovation Center for Genetics and Development; Fudan University - Human Phenome Institute; Fudan University - Taizhou Institute of Health Sciences

Li Jin

Fudan University - Collaborative Innovation Center for Genetics and Development; Fudan University - State Key Laboratory of Genetic Engineering; Fudan University - Taizhou Institute of Health Sciences; Fudan University - Human Phenome Institute

Weimin Ye

Karolinska Institutet - Department of Medical Epidemiology and Biostatistics

More...

Abstract

Background: Asymptomatic brain abnormalities are common incidental findings on brain MRI in the elderly population and can be regarded as imaging markers of early stroke and dementia. We initiated the Taizhou Imaging Study (TIS) to examine the prevalence and correlates of incidental findings using brain MRI among an elderly population residing in a rural area of China.

Methods: A total of 562 individuals, at the age of 55 to 65 years, participated in the TIS study with a response rate of 90%. The primary findings included lacunes, white matter hyperintensity (WMH), and cerebral microbleeds (CMB), perivascular space (PVS), intracranial arterial stenosis (ICAS), and others (venous angioma, etc.). The brain parenchymal fraction and the brain gray matter fraction (BGMF) were also estimated.

Findings: The prevalence of lacunes, WMH, CMB, PVS, and ICAS was 26.69%, 10.68%, 18.51%, 27.76%, and 12.81%, respectively. Age and hypertension were the major correlates of these incidental findings. Per each year increase in age, the risks of WMH and CMB increased by 15% and 14%. Compared to individuals with normal blood pressure, individuals with hypertension had an increased risk of all incidental findings, with the adjusted odds ratios of 2.28 to 5.45. Correlations of age, gender and BMI with BGMF were also observed.

Interpretation: The prevalence of MRI incidental findings was high in the rural Chinese population at the age of 55-65 years. The high prevalence of these findings indicates a need of preventative strategy to help prevent future stroke and dementia in this population.

Funding: The project was supported by the International Science and Technology Cooperation Program of China (grant number: 2014DFA32830), the Key Research and Development Plans of Jiangsu Province (grant number: BE2016726), the key basic research grants from Science and Technology Commission of Shanghai Municipality (grant number: 16JC1400500), the Karolinska Institutet (Senior Researcher Award and Strategic Research Area in Epidemiology), and the National Key Research and Development program of China (grant number: 2017YFC0907002, 2017YFC0907501).

Declaration of interests: We declare no competing interests.

Ethical Approval Statement: This study was approved by the Human Ethics Committee of School of Life Sciences of Fudan University (number of Institutional Review Board approval: 469).

Keywords: incidental findings; MRI; prevalence; Taizhou Imaging Study

Suggested Citation

Li, Shuyuan and Fang, Fang and Cui, Mei and Jiang, Yanfeng and Wang, Yingzhe and Kong, Xuhui and Tian, Weizhong and Fan, Min and Yuan, Ziyu and Chen, Jinhua and Yang, Qi and Xue, Fuzhong and Wang, Jiucun and Lu, Ming and Wang, Xiaofeng and Chen, Xingdong and Jin, Li and Ye, Weimin, Incidental Findings on Brain MRI Among Chinese at the Age of 55-65 Years: The Taizhou Imaging Study (July 16, 2018). Available at SSRN: https://ssrn.com/abstract=3215566 or http://dx.doi.org/10.2139/ssrn.3215566

Shuyuan Li

Shanghai Jiao Tong University (SJTU) - International Peace Maternity and Child Health Hospital

1961 Huashan Rd
Shanghai Shi, 200030
China

Fang Fang

Karolinska Institutet - Department of Medical Epidemiology and Biostatistics

SE-171 82 Solna
Sweden

Mei Cui

Fudan University - Department of Neurology ( email )

Beijing West District Baiyun Load 10th
Shanghai, 100045
China

Yanfeng Jiang

Fudan University - Collaborative Innovation Center for Genetics and Development

China

Fudan University - State Key Laboratory of Genetic Engineering

Shanghai
China

Fudan University - Taizhou Institute of Health Sciences

Taizhou
China

Yingzhe Wang

Fudan University - Huashan Hospital

Beijing West District Baiyun Load 10th
Shanghai, 100045
China

Xuhui Kong

Nantong University - Taizhou People's Hospital

China

Weizhong Tian

Nantong University - Taizhou People's Hospital

China

Min Fan

Taixing Disease Control and Prevention Center

China

Ziyu Yuan

Fudan University - Taizhou Institute of Health Sciences

Taizhou
China

Jinhua Chen

Nantong University - Taizhou People's Hospital

China

Qi Yang

Fudan University - Huashan Hospital

Beijing West District Baiyun Load 10th
Shanghai, 100045
China

Fuzhong Xue

Fudan University

Beijing West District Baiyun Load 10th
Shanghai, 100045
China

Shandong University

27 Shanda Nanlu
South Rd.
Jinan, Shandong 250100
China

Jiucun Wang

Fudan University

Beijing West District Baiyun Load 10th
Shanghai, 100045
China

Fudan University - Collaborative Innovation Center for Genetics and Development

China

Ming Lu

Shandong University - Clinical Epidemiology Unit ( email )

Jinan
China

Xiaofeng Wang

Fudan University - Collaborative Innovation Center for Genetics and Development

China

Xingdong Chen (Contact Author)

Fudan University - State Key Laboratory of Genetic Engineering ( email )

Shanghai
China

Fudan University - Collaborative Innovation Center for Genetics and Development

China

Fudan University - Human Phenome Institute ( email )

Shanghai
China

Fudan University - Taizhou Institute of Health Sciences ( email )

Taizhou
China

Li Jin

Fudan University - Collaborative Innovation Center for Genetics and Development

China

Fudan University - State Key Laboratory of Genetic Engineering

Shanghai
China

Fudan University - Taizhou Institute of Health Sciences

Taizhou
China

Fudan University - Human Phenome Institute

Shanghai
China

Weimin Ye

Karolinska Institutet - Department of Medical Epidemiology and Biostatistics

SE-171 82 Solna
Sweden

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