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Prenatal Exposure to Perfluoroalkyl Substances is Associated with Lower Hand, Foot and Mouth Disease Viruses Antibody Response in Early Childhood: Novel Findings from the Guangzhou Birth Cohort Study

27 Pages Posted: 7 Sep 2018

See all articles by Xiao-Wen Zeng

Xiao-Wen Zeng

Sun Yat-Sen University (SYSU)

Michael S. Bloom

Sun Yat-Sen University (SYSU) - Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment; University at Albany (SUNY)

Shyamali C. Dharmage

University of Melbourne

Caroline J. Lodge

University of Melbourne, School of Population and Global Health, Allergy and Lung Health Unit

Da Chen

Jinan University

Shanshan Li

Monash University

Yuming Guo

Monash University - School of Public Health and Preventive Medicine

Marjut Roponen

University of Eastern Finland

Pasi Jalava

University of Eastern Finland

Maija-Riitta Hirvonen

University of Eastern Finland

Steve Hung Lam Yim

The Chinese University of Hong Kong (CUHK) - Department of Geography and Resource Management; The Chinese University of Hong Kong (CUHK) - Institute of Environment, Energy and Sustainability; The Chinese University of Hong Kong (CUHK) - Stanley Ho Big Data Decision Analytics Research Centre

Huimin Ma

Chinese Academy of Sciences (CAS)

Duo-Hong Chen

Guangdong Environmental Protection Key Laboratory of Atmospheric Secondary Pollution

Yuan-Tao Hao

Sun Yat-Sen University (SYSU)

Wen Chen

Sun Yat-Sen University (SYSU)

Mo Yang

Sun Yat-Sen University (SYSU)

Chu Chu

Sun Yat-Sen University (SYSU)

Li-Wen Hu

Sun Yat-Sen University (SYSU) - Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment

Kang-Kang Liu

Sun Yat-Sen University (SYSU)

Bo-Yi Yang

Sun Yat-Sen University (SYSU) - Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment

Chuanxi Fu

Zhejiang Chinese Medical University

Guang-Hui Dong

Sun Yat-Sen University (SYSU) - Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment

More...

Abstract

Background: Hand Foot and Mouth Disease (HFMD) is a common, global childhood viral infection of which the incidence has substantially increased in the Asia-Pacific region paralleling the rise in exposure to perfluoroalkyl substances (PFASs). These two phenomena may be related. There is evidence that PFASs exposure is associated with immune system disruption in early life. We conducted the world's first study to assess whether prenatal exposure to PFAS was associated with a reduction in HFMD virus antibodies in early childhood.  

Methods: We enrolled 201 mother-infant pairs from the Guangzhou Birth Cohort Study in 2013.  PFAS isomer-specific analysis based on high performance liquid chromatography-mass spectrometry assessed the concentrations of PFAS isomers in cord blood. Neutralizing antibodies titers were measured against two HFMD viruses, enterovirus 71 (EV71) and coxsackievirus A 16 (CA16), in serum in cord blood and at three months of age.  

Findings: Higher prenatal PFAS exposure was associated with lower EV71 and CA16 antibody concentrations. A doubling in the composite sum of cord blood PFASs in three months old infants was associated with significant increase in the risk of HFMD antibody concentration below clinical protection level (>1:8 titers) for CA16 (odds ratio: 2·740 [95% confidence interval (CI): 1·33, 5·61] and for EV71 of 4·55 (95% CI: 1·45, 4·28). This association was apparent in boys at three months of age.

Funding Statement: This project was supported by Grants from the National Natural Science Foundation of China (No.81472936, No. 81673127 and No. 81172630), Major Infectious Disease Prevention and Control ofthe National Science and Technique Major Project (2018ZX10715004), the Project for KeyMedicine Discipline Construction of Guangzhou Municipality (No. 2017–2019–07), theFundamental Research Funds for the Central Universities (No. 17ykzd14), the Natural ScienceFoundation of Guangdong Province (No. 2016A030313342) and the State Key Laboratory of Organic Geochemistry, GIGCAS (No. SKLOG–201608). The above funding has not taken control of the study design 

Declaration of Interests: The authors declare that they have no conflicts of interest.

Ethics Approval Statement: Informed consent was obtained from participants. This study protocol was approved by the Institutional Review Board (Sun Yat–sen University Research Ethics Committee), and all study procedures were in accordance with the principles of Helsinki Declaration.

Keywords: Hand Foot and Mouth Disease, Antibody, Perfluoroalkyl Substances, Prenatal Exposure, the Guangzhou Birth Cohort Study

Suggested Citation

Zeng, Xiao-Wen and Bloom, Michael S. and Dharmage, Shyamali C. and Lodge, Caroline J. and Chen, Da and Li, Shanshan and Guo, Yuming and Roponen, Marjut and Jalava, Pasi and Hirvonen, Maija-Riitta and Yim, Steve Hung Lam and Ma, Huimin and Chen, Duo-Hong and Hao, Yuan-Tao and Chen, Wen and Yang, Mo and Chu, Chu and Hu, Li-Wen and Liu, Kang-Kang and Yang, Bo-Yi and Fu, Chuanxi and Dong, Guang-Hui, Prenatal Exposure to Perfluoroalkyl Substances is Associated with Lower Hand, Foot and Mouth Disease Viruses Antibody Response in Early Childhood: Novel Findings from the Guangzhou Birth Cohort Study (July 18, 2018). Available at SSRN: https://ssrn.com/abstract=3216856 or http://dx.doi.org/10.2139/ssrn.3216856

Xiao-Wen Zeng

Sun Yat-Sen University (SYSU)

135, Xingang Xi Road
Guangzhou, Guangdong 510275
China

Michael S. Bloom

Sun Yat-Sen University (SYSU) - Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment

China

University at Albany (SUNY)

1400 Washington Ave
Albany, NY 12222
United States

Shyamali C. Dharmage

University of Melbourne

185 Pelham Street
Carlton, Victoria 3053
Australia

Caroline J. Lodge

University of Melbourne, School of Population and Global Health, Allergy and Lung Health Unit

185 Pelham Street
Carlton, Victoria 3053
Australia

Da Chen

Jinan University

Huang Pu Da Dao Xi 601, Tian He District
Guangzhou, Guangdong 510632
China

Shanshan Li

Monash University

23 Innovation Walk
Wellington Road
Clayton, Victoria 3800
Australia

Yuming Guo

Monash University - School of Public Health and Preventive Medicine

Australia

Marjut Roponen

University of Eastern Finland

PO Box 111
Joensuu, 80100
Finland

Pasi Jalava

University of Eastern Finland

PO Box 111
Joensuu, 80100
Finland

Maija-Riitta Hirvonen

University of Eastern Finland

PO Box 111
Joensuu, 80100
Finland

Steve Hung Lam Yim

The Chinese University of Hong Kong (CUHK) - Department of Geography and Resource Management ( email )

Hong Kong
China

The Chinese University of Hong Kong (CUHK) - Institute of Environment, Energy and Sustainability ( email )

Shatin, N.T., Hong Kong
China

The Chinese University of Hong Kong (CUHK) - Stanley Ho Big Data Decision Analytics Research Centre ( email )

Shatin, N.T., Hong Kong
China

Huimin Ma

Chinese Academy of Sciences (CAS)

52 Sanlihe Rd.
Datun Road, Anwai
Beijing, Xicheng District 100864
China

Duo-Hong Chen

Guangdong Environmental Protection Key Laboratory of Atmospheric Secondary Pollution

China

Yuan-Tao Hao

Sun Yat-Sen University (SYSU)

135, Xingang Xi Road
Guangzhou, Guangdong 510275
China

Wen Chen

Sun Yat-Sen University (SYSU)

135, Xingang Xi Road
Guangzhou, Guangdong 510275
China

Mo Yang

Sun Yat-Sen University (SYSU)

135, Xingang Xi Road
Guangzhou, Guangdong 510275
China

Chu Chu

Sun Yat-Sen University (SYSU)

135, Xingang Xi Road
Guangzhou, Guangdong 510275
China

Li-Wen Hu

Sun Yat-Sen University (SYSU) - Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment

China

Kang-Kang Liu

Sun Yat-Sen University (SYSU)

135, Xingang Xi Road
Guangzhou, Guangdong 510275
China

Bo-Yi Yang

Sun Yat-Sen University (SYSU) - Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment

China

Chuanxi Fu

Zhejiang Chinese Medical University

Hangzhou, Zhejiang
China

Guang-Hui Dong (Contact Author)

Sun Yat-Sen University (SYSU) - Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment ( email )

China

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