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Noc4L Dependent Ribosome Biogenesis Controls Treg Activation

45 Pages Posted: 1 Aug 2018 Sneak Peek Status: Under Review

See all articles by Xueping Zhu

Xueping Zhu

Chinese Academy of Sciences (CAS), Institute of Microbiology, CAS Key Laboratory of Pathogenic Microbiology and Immunology

Wei Zhang

Chinese Academy of Sciences (CAS), Institute of Microbiology, CAS Key Laboratory of Pathogenic Microbiology and Immunology

Jie Guo

Chinese Academy of Sciences (CAS), Institute of Microbiology, CAS Key Laboratory of Pathogenic Microbiology and Immunology

Xuejie Zhang

Chinese Academy of Sciences (CAS), Institute of Microbiology, CAS Key Laboratory of Pathogenic Microbiology and Immunology

Jinghua Yan

Chinese Academy of Sciences (CAS), Institute of Microbiology, CAS Key Laboratory of Pathogenic Microbiology and Immunology

George F. Gao

Chinese Center for Disease Control and Prevention - National Institute for Viral Disease Control and Prevention

Xuyu Zhou

Chinese Academy of Sciences (CAS), Institute of Microbiology, CAS Key Laboratory of Pathogenic Microbiology and Immunology

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Abstract

Tregs activation is crucial for maintaining self-tolerance, but the translational regulation of this process is still poorly understood. Although ribosome biogenesis is considered a housekeeping process, emerging evidence supports a new hypothesis that different types of cells may actually contain distinct repertoires of ribosome biogenesis factors that generate specialized ribosomes and confer the translation of selected mRNAs. Here, we focused on the ribosome biogenesis factor Noc4L, based on the observations that Noc4L is highly expressed in activated Treg cells. Conditional Noc4L knockout in Tregs resulted in a lethal autoimmune phenotype, resembling Treg deficient "scurfy" mice. Interestingly, the Noc4L defect did not globally affect the overall protein translation in Tregs but rather was selectively detrimental to the expression of genes related to Treg activation. These results demonstrate the critical role of Noc4L dependent ribosome biogenesis in controlling the activation of Tregs and maintaining immune tolerance.

Suggested Citation

Zhu, Xueping and Zhang, Wei and Guo, Jie and Zhang, Xuejie and Yan, Jinghua and Gao, George F. and Zhou, Xuyu, Noc4L Dependent Ribosome Biogenesis Controls Treg Activation (2018). Available at SSRN: https://ssrn.com/abstract=3224534 or http://dx.doi.org/10.2139/ssrn.3224534
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Xueping Zhu

Chinese Academy of Sciences (CAS), Institute of Microbiology, CAS Key Laboratory of Pathogenic Microbiology and Immunology

China

Wei Zhang

Chinese Academy of Sciences (CAS), Institute of Microbiology, CAS Key Laboratory of Pathogenic Microbiology and Immunology

China

Jie Guo

Chinese Academy of Sciences (CAS), Institute of Microbiology, CAS Key Laboratory of Pathogenic Microbiology and Immunology

China

Xuejie Zhang

Chinese Academy of Sciences (CAS), Institute of Microbiology, CAS Key Laboratory of Pathogenic Microbiology and Immunology

China

Jinghua Yan

Chinese Academy of Sciences (CAS), Institute of Microbiology, CAS Key Laboratory of Pathogenic Microbiology and Immunology

China

George F. Gao

Chinese Center for Disease Control and Prevention - National Institute for Viral Disease Control and Prevention ( email )

China

Xuyu Zhou (Contact Author)

Chinese Academy of Sciences (CAS), Institute of Microbiology, CAS Key Laboratory of Pathogenic Microbiology and Immunology ( email )

China