header

Cortico-Efferent Tract Involvement in Primary Lateral Sclerosis and Amyotrophic Lateral Sclerosis: A Two-Center Tract of Interest-Based DTI Analysis

28 Pages Posted: 1 Aug 2018 First Look: Under Review

See all articles by Hans-Peter Müller

Hans-Peter Müller

University of Ulm - Department of Neurology

Federica Agosta

San Raffaele Hospital - Neuroimaging Research Unit

Martin Gorges

University of Ulm - Department of Neurology

Rebecca Kassubek

University of Ulm - Department of Neurology

Edoardo Gioele Spinelli

San Raffaele Hospital - Neuroimaging Research Unit

Nilo Riva

San Raffaele Hospital - Department of Neurology

Albert C. Ludolph

University of Ulm - Department of Neurology

Massimo Filippi

San Raffaele Hospital - Neuroimaging Research Unit

Jan Kassubek

University of Ulm - Department of Neurology

Abstract

Background: After the demonstration of a corticoefferent propagation pattern in amyotrophic lateral sclerosis (ALS) by neuropathological studies, this concept has been used for in vivo staging of individual patients by diffusion tensor imaging (DTI) techniques, both in `classical` ALS and in restricted phenotypes such as primary lateral sclerosis (PLS). Objective: The study was designed to identify microstructural changes according to the neuropathologically defined ALS affectation pattern in PLS patients compared with ´classical´ ALS patients and healthy controls. Methods: Tractwise analysis of fractional anisotropy (FA) maps according to the ALS-staging pattern was applied to DTI data (pooled from two ALS centers) of 88 PLS patients and 88 ALS patients with a 'classical' phenotype in comparison to 88 matched controls in order to identify white matter integrity alterations.

Results: In the tract-specific analysis, alterations were identical for PLS and ALS in the tract systems corresponding to the ALS staging pattern, independent of the subject samples and the data acquisition parameters. The individual categorization into ALS stages did not differ between PLS and ALS patients.

Conclusions: This DTI study in a two-center setting demonstrated that the neuropathological stages can be mapped in vivo in PLS with high reproducibility and that PLS-associated cerebral propagation, although showing the same corticofugal patterns as ALS, might have a different time course.

Suggested Citation

Müller, Hans-Peter and Agosta, Federica and Gorges, Martin and Kassubek, Rebecca and Spinelli, Edoardo Gioele and Riva, Nilo and Ludolph, Albert C. and Filippi, Massimo and Kassubek, Jan, Cortico-Efferent Tract Involvement in Primary Lateral Sclerosis and Amyotrophic Lateral Sclerosis: A Two-Center Tract of Interest-Based DTI Analysis (August 1, 2018). Available at SSRN: https://ssrn.com/abstract=3224672

Hans-Peter Müller

University of Ulm - Department of Neurology

Albert-Einstein-Alee 11
Ulm, D-89081
Germany

Federica Agosta

San Raffaele Hospital - Neuroimaging Research Unit

Milano
Italy

Martin Gorges

University of Ulm - Department of Neurology

Albert-Einstein-Alee 11
Ulm, D-89081
Germany

Rebecca Kassubek

University of Ulm - Department of Neurology

Albert-Einstein-Alee 11
Ulm, D-89081
Germany

Edoardo Gioele Spinelli

San Raffaele Hospital - Neuroimaging Research Unit

Milano
Italy

Nilo Riva

San Raffaele Hospital - Department of Neurology

Milan
Italy

Albert C. Ludolph

University of Ulm - Department of Neurology

Albert-Einstein-Alee 11
Ulm, D-89081
Germany

Massimo Filippi

San Raffaele Hospital - Neuroimaging Research Unit

Milano
Italy

Jan Kassubek (Contact Author)

University of Ulm - Department of Neurology ( email )

Albert-Einstein-Alee 11
Ulm, D-89081
Germany

Register to save articles to
your library

Register

Paper statistics

Abstract Views
185
PlumX Metrics
Downloads
8