Investigating Fractional Exhaled Nitric Oxide in Chronic Obstructive Pulmonary Disease (COPD) and Asthma-COPD Overlap (ACO): A Scoping Review

COPD: Journal of Chronic Obstructive Pulmonary Disease (2018)

Posted: 21 Aug 2018

See all articles by Seyed-Mohammad-Yousof Mostafavi-Pour-Manshadi

Seyed-Mohammad-Yousof Mostafavi-Pour-Manshadi

Respiratory Epidemiology and Clinical Research Unit, Research Institute of McGill University Health Centre, McGill University, Montreal, Canada

Nafiseh Naderi

McGill University - Division of Experimental Medicine; Respiratory Epidemiology and Clinical Research Unit, Research Institute of McGill University Health Centre, McGill University, Montreal, Canada

Miriam Barrecheguren

McGill University

Abolfazl Dehghan

Islamic Azad University (IAU)

Jean Bourbeau

Respiratory Epidemiology and Clinical Research Unit, Research Institute of McGill University Health Centre, McGill University, Montreal, Canada

Date Written: August 01, 2018

Abstract

Chronic obstructive pulmonary disease (COPD) is the most common fixed airflow limitation. Individuals may present with the features of both asthma and COPD called asthma-COPD overlap (ACO) with more severity and worse health-related quality of life than COPD or asthma. One of the promising biomarkers that could be used in clinical practice to differentiate ACO from COPD is fractional exhaled nitric oxide (FENO). The role of Fractional exhaled nitric oxide (FENO) in COPD/ ACO remains unknown. This scoping review aims to investigate the role of FENO measurement to differentiate COPD from ACO, to anticipate disease severity/progression and treatment response. A structured comprehensive literature search was performed in major databases including Medline, EMBASE, CINAHL, Cochrane Library, Web of Science, and BIOSIS from 2005 onwards. Thirty-eight studies were retrieved. Based on the synthesis of the reviewed literature, six themes emerged. Thirty-four articles covered more than one theme. From which, 24 articles were on modifying factors in FENO measurement, 18 on FENO in COPD compared with healthy subjects, and seven on FENO in ACO compared with COPD, 22 on FENO and disease severity/progression,12 on FENO and biomarkers, and eight on FENO and treatment response. FENO measurement cannot be used alone in the clinical settings of COPD patients. Although FENO level is higher in ACO patients than COPD-only, it is still unclear if there is a FENO cut-off that can be used to make the diagnosis of ACO and/or to guide therapy with inhaled corticosteroids/glucocorticoids in COPD patients.

Keywords: fractional exhaled nitric oxide (FENO), chronic obstructive pulmonary disease (COPD), asthma-COPD overlap (ACO)

Suggested Citation

Mostafavi-Pour-Manshadi, Seyed-Mohammad-Yousof and Naderi, Nafiseh and Barrecheguren, Miriam and Dehghan, Abolfazl and Bourbeau, Jean, Investigating Fractional Exhaled Nitric Oxide in Chronic Obstructive Pulmonary Disease (COPD) and Asthma-COPD Overlap (ACO): A Scoping Review (August 01, 2018). COPD: Journal of Chronic Obstructive Pulmonary Disease (2018) . Available at SSRN: https://ssrn.com/abstract=3228949

Seyed-Mohammad-Yousof Mostafavi-Pour-Manshadi

Respiratory Epidemiology and Clinical Research Unit, Research Institute of McGill University Health Centre, McGill University, Montreal, Canada ( email )

Montreal, Quebec
Canada

Nafiseh Naderi

McGill University - Division of Experimental Medicine ( email )

Montreal, Quebec
Canada

Respiratory Epidemiology and Clinical Research Unit, Research Institute of McGill University Health Centre, McGill University, Montreal, Canada ( email )

Miriam Barrecheguren

McGill University ( email )

1001 Sherbrooke St. W
Montreal, Quebec H3A 1G5
Canada

Abolfazl Dehghan

Islamic Azad University (IAU) ( email )

Hamedan, Iran
Tehran, Isfahan 461-15655
Iran

Jean Bourbeau (Contact Author)

Respiratory Epidemiology and Clinical Research Unit, Research Institute of McGill University Health Centre, McGill University, Montreal, Canada ( email )

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