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Bioinformatic Screening of Genes Present Only in Well Regenerating Vertebrates Reveals Novel FGF and Purinergic Signaling Modulator - C-Answer

57 Pages Posted: 17 Aug 2018 Sneak Peek Status: Under Review

See all articles by Daria D. Korotkova

Daria D. Korotkova

Russian Academy of Sciences (RAS) - Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry

Vassily A. Lyubetsky

Russian Academy of Sciences (RAS) - Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry

Anastasia S. Ivanova

Russian Academy of Sciences (RAS) - Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry

Lev I. Rubanov

Russian Academy of Sciences (RAS) - Information Transmission Problems Institute

Alexander V. Seliverstov

Russian Academy of Sciences (RAS) - Information Transmission Problems Institute

Oleg A. Zverkov

Russian Academy of Sciences (RAS) - Information Transmission Problems Institute

Natalia Yu. Martynova

Russian Academy of Sciences (RAS) - Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry

Maria B. Tereshina

Russian Academy of Sciences (RAS) - Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry

Alexey M. Nesterenko

Russian Academy of Sciences (RAS) - Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry

Leonid Peshkin

Harvard University - Department of Systems Biology

Andrey Zaraisky

Russian Academy of Sciences (RAS) - Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry

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Abstract

The genetic basis of higher regenerative capacity of fishes, amphibians and reptiles compared to birds and mammals is still poorly understood. Though it is thought to be a result of restructuring in the regulatory network of a static set of genes, we argued that it could be due to the loss of genes essential for regeneration. In the present work, we formulate a bioinformatic approach to systematic search for the such genes. Having identified them, we further investigated one we dubbed “c-Answer”, which encodes a membrane protein, regulating the regeneration of body appendages and the telencephalic development through binding to FGFR and P2Y1 receptors and promoting MAPK/ERK and purinergic signaling. The obtained data suggest that elimination of c-Answer in the ancestors of warm-blooded animals conditioned the decreased activity of at least two signaling pathways, which in turn could contribute to changes in mechanisms that regulate the forebrain development and regeneration.

Suggested Citation

Korotkova, Daria D. and Lyubetsky, Vassily A. and Ivanova, Anastasia S. and Rubanov, Lev I. and Seliverstov, Alexander V. and Zverkov, Oleg A. and Martynova, Natalia Yu. and Tereshina, Maria B. and Nesterenko, Alexey M. and Peshkin, Leonid and Zaraisky, Andrey, Bioinformatic Screening of Genes Present Only in Well Regenerating Vertebrates Reveals Novel FGF and Purinergic Signaling Modulator - C-Answer (2018). Available at SSRN: https://ssrn.com/abstract=3232160 or http://dx.doi.org/10.2139/ssrn.3232160
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Daria D. Korotkova

Russian Academy of Sciences (RAS) - Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry

Moscow, 117997
Russia

Vassily A. Lyubetsky

Russian Academy of Sciences (RAS) - Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry

Moscow, 117997
Russia

Anastasia S. Ivanova

Russian Academy of Sciences (RAS) - Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry

Moscow, 117997
Russia

Lev I. Rubanov

Russian Academy of Sciences (RAS) - Information Transmission Problems Institute

Moscow
Russia

Alexander V. Seliverstov

Russian Academy of Sciences (RAS) - Information Transmission Problems Institute

Moscow
Russia

Oleg A. Zverkov

Russian Academy of Sciences (RAS) - Information Transmission Problems Institute

Moscow
Russia

Natalia Yu. Martynova

Russian Academy of Sciences (RAS) - Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry

Moscow, 117997
Russia

Maria B. Tereshina

Russian Academy of Sciences (RAS) - Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry

Moscow, 117997
Russia

Alexey M. Nesterenko

Russian Academy of Sciences (RAS) - Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry

Moscow, 117997
Russia

Leonid Peshkin

Harvard University - Department of Systems Biology

Boston,, MA 02115
United States

Andrey Zaraisky (Contact Author)

Russian Academy of Sciences (RAS) - Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry ( email )

Moscow, 117997
Russia