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Interaction between Prediabetes and the ABO Blood Types in Predicting Postsurgical Esophageal Squamous Cell Carcinoma-Specific Mortality: The FIESTA Study

28 Pages Posted: 21 Sep 2018

See all articles by Guohui Fan

Guohui Fan

Government of the People's Republic of China - China-Japan Friendship Hospital

Dan Hu

Fujian Medical University

Feng Peng

Fujian Medical University - Department of Cardiology

Xinran Zhang

Government of the People's Republic of China - China-Japan Friendship Hospital

Xiandong Lin

Fujian Medical University - Laboratory of Radiobiology

Gang Chen

Fujian Medical University - Fujian Provincial Hospital

Binying Liang

Fujian Medical University

Hejun Zhang

Fujian Medical University

Yan Xia

Fujian Medical University

Xiongwei Zheng

Fujian Medical University

Jianzheng Jie

Government of the People's Republic of China - China-Japan Friendship Hospital

Wenquan Niu

Government of the People's Republic of China - Institute of Clinical Medical Sciences

More...

Abstract

Objectives: We aimed to investigate the interaction between prediabetes and the ABO blood types in predicting esophageal squamous cell carcinoma (ESCC)-specific mortality by analyzing data from the FIESTA study on normal/prediabetic patients with ESCC.  

Methods: Total 1857 normal/prediabetic patients with ESCC who underwent three-field lymphadenectomy between January 2000 and December 2010 and survived hospitalization were analyzable, with follow-up beginning in 2000 and ending in 2015.  

Results: At the end of the follow-up, there were 1161 survivors and 696 non-survivors. The follow-up time ranged from 0.5 months to 180 months. The cumulative survival rates in normal patients were obviously better than in prediabetic patients. The cumulative survival rates were significantly higher in normal patients than in prediabetic patients for the blood types O and A (Log-rank test P<0.05), while no significance was detected for the blood types B and AB. Adjusted risk estimates for ESCC-specific mortality for prediabetic patients relative to normal patients were statistically significant in the blood type B- group (hazard ratio [HR]: 1.71; 95% confidence interval [CI]: 1.33-2.20; P<0.001), but not in the blood type B group (HR: 1.12; 95% CI: 0.77-1.64; P=0.5544).  

Conclusions: Our findings indicate that prediabetes can predict the significant risk of ESCC-specific mortality in patients with the blood types O and A.

Funding Statement: This study was financially supported by the Natural Science Foundation of Fujian Province (grants no. 2016J01503, 2016J01508), the Training Project for Young and Middle-Aged Core Talents of Health System of Fujian Province (grants no. 2015-ZQN-JC-7) and the Ministry of Health P.R. China (WKJ2016-2-05). The funders of this study had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.

Declaration of Interests: The authors declare that they have no competing interests.

Ethics Approval Statement: The study proposal was approved by Ethics Committee of Fujian Cancer Hospital. All patients gave written informed consent.

Keywords: esophageal squamous cell carcinoma; prediabetes; the ABO blood type; prognosis; the FIESTA study

Suggested Citation

Fan, Guohui and Hu, Dan and Peng, Feng and Zhang, Xinran and Lin, Xiandong and Chen, Gang and Liang, Binying and Zhang, Hejun and Xia, Yan and Zheng, Xiongwei and Jie, Jianzheng and Niu, Wenquan, Interaction between Prediabetes and the ABO Blood Types in Predicting Postsurgical Esophageal Squamous Cell Carcinoma-Specific Mortality: The FIESTA Study (December 8, 2018). Available at SSRN: https://ssrn.com/abstract=3234802

Guohui Fan

Government of the People's Republic of China - China-Japan Friendship Hospital

China

Dan Hu

Fujian Medical University

Fuzhou
China

Feng Peng

Fujian Medical University - Department of Cardiology ( email )

Fuzhou
China

Xinran Zhang

Government of the People's Republic of China - China-Japan Friendship Hospital

China

Xiandong Lin

Fujian Medical University - Laboratory of Radiobiology

420 Fuma Rd
Fuzhou, 350014
China

Gang Chen

Fujian Medical University - Fujian Provincial Hospital

Fuzhou
China

Binying Liang

Fujian Medical University

Fuzhou
China

Hejun Zhang

Fujian Medical University

Fuzhou
China

Yan Xia

Fujian Medical University

Fuzhou
China

Xiongwei Zheng

Fujian Medical University

Fuzhou
China

Jianzheng Jie

Government of the People's Republic of China - China-Japan Friendship Hospital ( email )

China

Wenquan Niu (Contact Author)

Government of the People's Republic of China - Institute of Clinical Medical Sciences ( email )

Beijing
China

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