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Cross-Talk between Distinct Receptors Shapes Itch Behavior in the Spinal Cord

50 Pages Posted: 15 Sep 2018 Sneak Peek Status: Review Complete

See all articles by Qing-Tao Meng

Qing-Tao Meng

Washington University in St. Louis - Center for the Study of Itch

Xian-Yu Liu

Washington University in St. Louis - Center for the Study of Itch

Xue-Ting Liu

Washington University in St. Louis - Center for the Study of Itch

Devin M. Barry

Washington University in St. Louis - Center for the Study of Itch

Hua Jin

Washington University in St. Louis - Center for the Study of Itch

Qianyi Yang

Washington University in St. Louis - Center for the Study of Itch

Yu Sun

Washington University in St. Louis - Center for the Study of Itch

Li Wan

Washington University in St. Louis - Center for the Study of Itch

Jin-Hua Jin

Washington University in St. Louis - Center for the Study of Itch

Admire Munanairi

Washington University in St. Louis - Center for the Study of Itch

Ray Kim

Washington University in St. Louis - Center for the Study of Itch

Jun Yin

Washington University in St. Louis - Center for the Study of Itch

Ailin Tao

Guangzhou Medical University - State Key Laboratory of Respiratory Disease

Zhou-Feng Chen

Washington University in St. Louis - Center for the Study of Itch

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Abstract

Natriuretic peptide (NP) family comprises multiple peptides/receptors whose respective role in itch transmission remains unclear. We report that about 23% of Npr1 that encodes NP receptor A (NPRA) in the superficial spinal cord co-express gastrin-releasing peptide (Grp), while Npr3 that encodes NP receptor C (NPRC), partially overlaps with the neuromedin B receptor (NMBR) required for histamine-evoked itch. While Npr1 is required for chloroquine- (CQ) and histamine-evoked itch, the role of Npr3 is limited to the latter. Notably, B-type natriuretic peptide (BNP) significantly facilitated NMB-, but not GRP-, evoked scratching behavior, and Ca2 response in NMBR/NPRC cells. Consistently, BNP-saporin ablated spinal Npr1 and Npr3 neurons and impaired histamine-, but not CQ-evoked, itch. Thus, the findings identify the role of BNP-NPRC signaling in modulation of histamine-evoked itch via NPRC-NMBR cross-talk independent of GRP-GRPR signaling. Our studies reveal distinct modes of action for bombesin-related peptides and NP in itch transmission.

Suggested Citation

Meng, Qing-Tao and Liu, Xian-Yu and Liu, Xue-Ting and Barry, Devin M. and Jin, Hua and Yang, Qianyi and Sun, Yu and Wan, Li and Jin, Jin-Hua and Munanairi, Admire and Kim, Ray and Yin, Jun and Tao, Ailin and Chen, Zhou-Feng, Cross-Talk between Distinct Receptors Shapes Itch Behavior in the Spinal Cord (September 14, 2018). Available at SSRN: https://ssrn.com/abstract=3249822 or http://dx.doi.org/10.2139/ssrn.3249822
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Qing-Tao Meng (Contact Author)

Washington University in St. Louis - Center for the Study of Itch

One Brookings Drive
Campus Box 1208
St. Louis, MO 63130-4899
United States

Xian-Yu Liu

Washington University in St. Louis - Center for the Study of Itch

One Brookings Drive
Campus Box 1208
St. Louis, MO 63130-4899
United States

Xue-Ting Liu

Washington University in St. Louis - Center for the Study of Itch

One Brookings Drive
Campus Box 1208
St. Louis, MO 63130-4899
United States

Devin M. Barry

Washington University in St. Louis - Center for the Study of Itch

One Brookings Drive
Campus Box 1208
St. Louis, MO 63130-4899
United States

Hua Jin

Washington University in St. Louis - Center for the Study of Itch

One Brookings Drive
Campus Box 1208
St. Louis, MO 63130-4899
United States

Qianyi Yang

Washington University in St. Louis - Center for the Study of Itch

One Brookings Drive
Campus Box 1208
St. Louis, MO 63130-4899
United States

Yu Sun

Washington University in St. Louis - Center for the Study of Itch

One Brookings Drive
Campus Box 1208
St. Louis, MO 63130-4899
United States

Li Wan

Washington University in St. Louis - Center for the Study of Itch

One Brookings Drive
Campus Box 1208
St. Louis, MO 63130-4899
United States

Jin-Hua Jin

Washington University in St. Louis - Center for the Study of Itch

One Brookings Drive
Campus Box 1208
St. Louis, MO 63130-4899
United States

Admire Munanairi

Washington University in St. Louis - Center for the Study of Itch

One Brookings Drive
Campus Box 1208
St. Louis, MO 63130-4899
United States

Ray Kim

Washington University in St. Louis - Center for the Study of Itch

One Brookings Drive
Campus Box 1208
St. Louis, MO 63130-4899
United States

Jun Yin

Washington University in St. Louis - Center for the Study of Itch

One Brookings Drive
Campus Box 1208
St. Louis, MO 63130-4899
United States

Ailin Tao

Guangzhou Medical University - State Key Laboratory of Respiratory Disease

Guangzhou, 510260
China

Zhou-Feng Chen

Washington University in St. Louis - Center for the Study of Itch ( email )

One Brookings Drive
Campus Box 1208
St. Louis, MO 63130-4899
United States

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