Preprints with The Lancet is part of SSRN´s First Look, a place where journals identify content of interest prior to publication. Authors have opted in at submission to The Lancet family of journals to post their preprints on Preprints with The Lancet. The usual SSRN checks and a Lancet-specific check for appropriateness and transparency have been applied. Preprints available here are not Lancet publications or necessarily under review with a Lancet journal. These preprints are early stage research papers that have not been peer-reviewed. The findings should not be used for clinical or public health decision making and should not be presented to a lay audience without highlighting that they are preliminary and have not been peer-reviewed. For more information on this collaboration, see the comments published in The Lancet about the trial period, and our decision to make this a permanent offering, or visit The Lancet´s FAQ page, and for any feedback please contact firstname.lastname@example.org.
Ultra-Processed Food Consumption and All-Cause Mortality: The University of Navarra Follow-Up (SUN) Cohort
26 Pages Posted: 30 Sep 2018More...
Background: Ultra-processed foods (UPFs) consumption has increased in the past decade. Because of its nutritional composition, evidence suggests a potential association between UPFs consumption and higher risk of all-cause mortality. No prospective study has investigated this relationship.
Methods: We evaluated the association between UPFs consumption and the risk of mortality in a dynamic, prospective Spanish cohort of university graduates, the "Seguimiento Universidad de Navarra" (SUN) study. We used data from 19,897 participants followed-up between December 1999 and February 2014 for a median of 10·4 years with a retention rate of 90·9%. UPFs consumption (defined as food and drink products ready to eat, drink, or heat and made predominantly or entirely from processed items extracted or refined from whole foods or synthesized in the laboratory) was assessed with the use of a validated semi-quantitative 136-item foodfrequency questionnaire (FFQ). We adjusted UPFs consumption for energy intake using the residuals method. Participants were classified according to their energy-adjusted UPFs consumption into quartiles. Cox proportional hazards models were used to estimate adjusted Hazards Ratio (HR) and 95% confidence intervals (CI) for all-cause mortality.
Findings: We registered 335 deaths in 198,556 persons-years of follow-up. Participants in the highest quartile of UPFs consumption had a higher risk for all-cause mortality compared to those in the first quartile (multivariable-adjusted HR=1·62; 95% CI: 1·13-2·32) with a significant dose-response trend (p for linear trend=0·005). For each additional serving of UPFs consumption, mortality relatively increased by 9% (HR=1·09; 95% CI: 1·02-1·17).
Interpretation: UPFs consumption was associated with an increased risk for all-cause mortality in a prospective cohort of Spanish middle-aged adult university graduates. Further longitudinal studies are needed to confirm our results.
Funding Statement: The SUN Project has been supported by the Spanish Government-Instituto de Salud Carlos III, and the European Regional Development Fund (FEDER) (RD 06/0045, PI14/01798, PI14/01764, PI17/01795), the Navarra Regional Government, and the University of Navarra.
Declaration of Interests: The authors declared no potential conflicts of interest with respect to the research, authorship, and publication of this article.
Ethics Approval Statement: The Institutional Review Board (IRB) of the University of Navarra approved the protocol and the methods used to obtain consent of participants, conforming to the principles embodied in the Declaration of Helsinki. The SUN project was registered at clinicaltrials.gov as NCT02669602.
Suggested Citation: Suggested Citation