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Association Between the Pregnancy Exposome and Fetal Growth

38 Pages Posted: 11 Oct 2018

See all articles by Lydiane Agier

Lydiane Agier

University Grenoble Alpes - Institute for Advanced Biosciences (IAB)

Xavier Basagaña

Barcelona Institute for Global Health (ISGlobal)

Carles Hernandez-Ferrer

Barcelona Institute for Global Health (ISGlobal)

Léa Maitre

Barcelona Institute for Global Health (ISGlobal)

Ibon Tamayo Uria

Barcelona Institute for Global Health (ISGlobal)

Jose Urquiza

Barcelona Institute for Global Health (ISGlobal)

Sandra Andrusaityte

Vytauto Didziojo Universitetas

Maribel Casas

Barcelona Institute for Global Health (ISGlobal)

Montserrat de Castro

Barcelona Institute for Global Health (ISGlobal)

Enrique M. Cequier

Norwegian Institute of Public Health

Leda Chatzi

University of Southern California

David Donaire

Barcelona Institute for Global Health (ISGlobal)

Lise Giorgis-Allemand

University Grenoble Alpes - Institute for Advanced Biosciences (IAB)

Juan Ramon Gonzalez

Barcelona Institute for Global Health (ISGlobal)

Regina Grazuleviciene

Vytauto Didziojo Universitetas

Kristine B. Gützkow

Norwegian Institute of Public Health

Line S. Haug

Norwegian Institute of Public Health

Amrit K. Sakhi

Norwegian Institute of Public Health

Rosemary R C McEachan

NHS Foundation Trust

Helle Margrete Meltzer

Norwegian Institute of Public Health

Mark Nieuwenhuijsen

Barcelona Institute for Global Health (ISGlobal); Universitat Pompeu Fabra; Instituto de Salud Carlos III - CIBER de Epidemiología y Salud Pública (CIBERESP)

Oliver Robinson

Imperial College London - Department of Epidemiology and Biostatistics

Theano Roumeliotaki

University of Crete

Jordi Sunyer

Barcelona Institute for Global Health (ISGlobal)

Cathrine Thomsen

Barcelona Institute for Global Health (ISGlobal)

Marina Vafeiadi

University of Crete

Antonia Valentin

NHS Foundation Trust

Jane West

NHS Foundation Trust

John Wright

NHS Foundation Trust

Valérie Siroux

University Grenoble Alpes

Martine Vrijheid

Barcelona Institute for Global Health (ISGlobal)

Remy Slama

University Grenoble Alpes - Institute for Advanced Biosciences (IAB)

More...

Abstract

Background: Several environmental contaminants were reported to possibly influence fetal growth, generally from single exposure family studies,  which are prone to publication bias. The exposome paradigm offers perspectives to avoid selective reporting of findings and to control for confounding by co-exposures.  

Objectives: We aimed to assess the association of the pregnancy chemical and external exposomes with fetal growth.  

Methods: Within HELIX project, 131 prenatal exposures were assessed using biomarkers and environmental models in 1,287 mother-child pairs from six European cohorts. We investigated their associations with fetal growth using a deletion-substitution-addition (DSA) algorithm considering all exposures simultaneously, and an exposome-wide association study (ExWAS) considering each exposure independently. We corrected for exposure misclassification, and tested for exposure-exposure and sex-exposure interactions.  

Findings: Lead blood level was the only exposure associated with fetal growth in the DSA model (97g weight decrease for each doubling in lead concentration). No exposure passed the multiple testing-corrected significance threshold of ExWAS; without multiple testing correction, this model was in favor of a negative association of fine particulate matter concentration with birth weight; and of a positive sex-specific association of parabens with birth weight in boys only. No two-way interaction between exposure variables was identified.  

Interpretation: This first large-scale exposome study of fetal growth simultaneously considered over 100 environmental exposures. Compared to single exposure studies, our approach allowed making all tests (usually reported in successive publications) explicit. Lead exposure is still a health concern in Europe and parabens health effects warrant further investigation.  

Funding Statement: FP7/2007-2013, HELIX project (no 308333).  

Declaration of Interests: The authors declare no conflict of interest.

Ethics Approval Statement: The study was approved by the relevant ethical committees from each country and an informed consent form was assigned from all participants, or the parents of the children.

Keywords: cohort, chemical exposures, environment, exposome, fetal growth, mixtures

Suggested Citation

Agier, Lydiane and Basagaña, Xavier and Hernandez-Ferrer, Carles and Maitre, Léa and Tamayo Uria, Ibon and Urquiza, Jose and Andrusaityte, Sandra and Casas, Maribel and de Castro, Montserrat and Cequier, Enrique M. and Chatzi, Leda and Donaire, David and Giorgis-Allemand, Lise and Ramon Gonzalez, Juan and Grazuleviciene, Regina and Gützkow, Kristine B. and Haug, Line S. and Sakhi, Amrit K. and McEachan, Rosemary R C and Meltzer, Helle Margrete and Nieuwenhuijsen, Mark and Robinson, Oliver and Roumeliotaki, Theano and Sunyer, Jordi and Thomsen, Cathrine and Vafeiadi, Marina and Valentin, Antonia and West, Jane and Wright, John and Siroux, Valérie and Vrijheid, Martine and Slama, Remy, Association Between the Pregnancy Exposome and Fetal Growth (September 26, 2018). Available at SSRN: https://ssrn.com/abstract=3258668 or http://dx.doi.org/10.2139/ssrn.3258668

Lydiane Agier

University Grenoble Alpes - Institute for Advanced Biosciences (IAB)

La Tronche, 38700
France

Xavier Basagaña

Barcelona Institute for Global Health (ISGlobal)

Spain

Carles Hernandez-Ferrer

Barcelona Institute for Global Health (ISGlobal) ( email )

Spain

Léa Maitre

Barcelona Institute for Global Health (ISGlobal)

Spain

Ibon Tamayo Uria

Barcelona Institute for Global Health (ISGlobal)

Spain

Jose Urquiza

Barcelona Institute for Global Health (ISGlobal)

Spain

Sandra Andrusaityte

Vytauto Didziojo Universitetas

Kaunas
Lithuania

Maribel Casas

Barcelona Institute for Global Health (ISGlobal)

Spain

Montserrat De Castro

Barcelona Institute for Global Health (ISGlobal)

Spain

Enrique M. Cequier

Norwegian Institute of Public Health

PO Box 4404
Nydalen, N-0403
Oslo
Norway

Leda Chatzi

University of Southern California

2250 Alcazar Street
Los Angeles, CA 90089
United States

David Donaire

Barcelona Institute for Global Health (ISGlobal)

Spain

Lise Giorgis-Allemand

University Grenoble Alpes - Institute for Advanced Biosciences (IAB)

La Tronche, 38700
France

Juan Ramon Gonzalez

Barcelona Institute for Global Health (ISGlobal)

Spain

Regina Grazuleviciene

Vytauto Didziojo Universitetas

Kaunas
Lithuania

Kristine B. Gützkow

Norwegian Institute of Public Health

PO Box 4404
Nydalen, N-0403
Oslo
Norway

Line S. Haug

Norwegian Institute of Public Health

PO Box 4404
Nydalen, N-0403
Oslo
Norway

Amrit K. Sakhi

Norwegian Institute of Public Health

PO Box 4404
Nydalen, N-0403
Oslo
Norway

Rosemary R C McEachan

NHS Foundation Trust

London, SE5 8AZ
United Kingdom

Helle Margrete Meltzer

Norwegian Institute of Public Health ( email )

PO Box 4404
Nydalen, N-0403
Oslo
Norway

Mark Nieuwenhuijsen

Barcelona Institute for Global Health (ISGlobal) ( email )

Barcelona, 08003
Spain

Universitat Pompeu Fabra ( email )

Ramon Trias Fargas, 25-27
Barcelona, E-08005
Spain

Instituto de Salud Carlos III - CIBER de Epidemiología y Salud Pública (CIBERESP) ( email )

Monforte de Lemos 5
Madrid
Spain

Oliver Robinson

Imperial College London - Department of Epidemiology and Biostatistics

St Mary's Campus
Norfolk Pl, Paddington
London, W2 1QN
United Kingdom

Theano Roumeliotaki

University of Crete

Rethymno, RETHIMNO GR-74100
Greece

Jordi Sunyer

Barcelona Institute for Global Health (ISGlobal)

Spain

Cathrine Thomsen

Barcelona Institute for Global Health (ISGlobal)

Spain

Marina Vafeiadi

University of Crete

Rethymno, RETHIMNO GR-74100
Greece

Antonia Valentin

NHS Foundation Trust

London, SE5 8AZ
United Kingdom

Jane West

NHS Foundation Trust

London, SE5 8AZ
United Kingdom

John Wright

NHS Foundation Trust

London, SE5 8AZ
United Kingdom

Valérie Siroux

University Grenoble Alpes

151 Rue des Universités
Saint-Martin-d'Hères, 38400
France

Martine Vrijheid

Barcelona Institute for Global Health (ISGlobal)

Spain

Remy Slama (Contact Author)

University Grenoble Alpes - Institute for Advanced Biosciences (IAB) ( email )

La Tronche, 38700
France

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