Dual Effects of ALDH2 rs671 on Biochemical Indicators in Chinese Males
14 Pages Posted: 9 Oct 2018More...
Background: Aldehyde dehydrogenase 2 (ALDH2) encodes a key enzyme to play a crucial role in alcohol detoxification, oxidative stress and inflammation regulation. ALDH2 rs671, a famous variant appreciably impairing enzymatic activity, is prevalent in almost 560 million East Asians. Accumulating studies have confirmed its association with serious illnesses including cancers, metabolic syndrome and organic damage, but supporting evidence from healthy population remains limited.
Methods: Considering its prominent role in males suggested by previous studies, we recruited 1,491 Chinese males from health examination to comprehensively investigate the effects of ALDH2 rs671 on multiple biochemical indicators. Genotypes of this variant was detected by Sanger sequencing. Biochemical indicators were measured by standard laboratory methods.
Results: ALDH2 rs671 was found to be widely associated with blood glucose, lipids, hepatic and renal function (P > 0.05). Remarkably, compared with wild type, males carrying rs671 A allele had less levels of risk index of hepatic injury (OR = 0.29, 95% CI= 0.21-0.41, P = 6.926x10-14) and metabolic syndrome (OR = 0.48, 95% CI= 0.25-0.94, P = 0.033), but interestingly, they were prone to suffer risk of renal injury (OR = 1.74, 95% CI= 1.27-2.39, P = 0.001).
Conclusion: Our findings highlight the wide and dual effects of ALDH2 rs671 on biochemical indicators in healthy Chinese males, which not only provide supporting evidence from healthy population for ALDH2-realted diseases, but also help to identify high-risk individuals for early warning.
Funding Statement: This work was supported by the National Natural Science Foundation of China (No. 81601839).
Declaration of Interests: The authors declare no competing financial interests.
Ethics Approval Statement: All the eligible subjects gave informed consent. This study was approved by the ethical review committees of the Tongji Hospital.
Keywords: aldehyde dehydrogenase 2 (ALDH2); rs671; biochemical indicators
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