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Dual Effects of ALDH2 rs671 on Biochemical Indicators in Chinese Males

14 Pages Posted: 9 Oct 2018

See all articles by Na Shen

Na Shen

Huazhong University of Science and Technology (Formerly Tongi Medical University)

Xiong Wang

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Laboratory Medicine

Delei Li

Huazhong University of Science and Technology (Formerly Tongi Medical University)

Ting Wang

Huazhong University of Science and Technology (Formerly Tongi Medical University)

Yongman Lv

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Physical Examination Center

Yanjun Lu

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Laboratory Medicine

More...

Abstract

Background: Aldehyde dehydrogenase 2 (ALDH2) encodes a key enzyme to play a crucial role in alcohol detoxification, oxidative stress and inflammation regulation. ALDH2 rs671, a famous variant appreciably impairing enzymatic activity, is prevalent in almost 560 million East Asians. Accumulating studies have confirmed its association with serious illnesses including cancers, metabolic syndrome and organic damage, but supporting evidence from healthy population remains limited.

Methods: Considering its prominent role in males suggested by previous studies, we recruited 1,491 Chinese males from health examination to comprehensively investigate the effects of ALDH2 rs671 on multiple biochemical indicators. Genotypes of this variant was detected by Sanger sequencing. Biochemical indicators were measured by standard laboratory methods.

Results: ALDH2 rs671 was found to be widely associated with blood glucose, lipids, hepatic and renal function (P > 0.05). Remarkably, compared with wild type, males carrying rs671 A allele had less levels of risk index of hepatic injury (OR = 0.29, 95% CI= 0.21-0.41, P = 6.926x10-14) and metabolic syndrome (OR = 0.48, 95% CI= 0.25-0.94, P = 0.033), but interestingly, they were prone to suffer risk of renal injury (OR = 1.74, 95% CI= 1.27-2.39, P = 0.001).

Conclusion: Our findings highlight the wide and dual effects of ALDH2 rs671 on biochemical indicators in healthy Chinese males, which not only provide supporting evidence from healthy population for ALDH2-realted diseases, but also help to identify high-risk individuals for early warning.

Funding Statement: This work was supported by the National Natural Science Foundation of China (No. 81601839).

Declaration of Interests: The authors declare no competing financial interests.

Ethics Approval Statement: All the eligible subjects gave informed consent. This study was approved by the ethical review committees of the Tongji Hospital.

Keywords: aldehyde dehydrogenase 2 (ALDH2); rs671; biochemical indicators

Suggested Citation

Shen, Na and Wang, Xiong and Li, Delei and Wang, Ting and Lv, Yongman and Lu, Yanjun, Dual Effects of ALDH2 rs671 on Biochemical Indicators in Chinese Males (March 10, 2018). Available at SSRN: https://ssrn.com/abstract=3260778 or http://dx.doi.org/10.2139/ssrn.3260778

Na Shen

Huazhong University of Science and Technology (Formerly Tongi Medical University)

1037 Luoyu Rd
Wuhan, Hubei 430074
China

Xiong Wang

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Laboratory Medicine

Wuhan
China

Delei Li

Huazhong University of Science and Technology (Formerly Tongi Medical University)

1037 Luoyu Rd
Wuhan, Hubei 430074
China

Ting Wang

Huazhong University of Science and Technology (Formerly Tongi Medical University)

1037 Luoyu Rd
Wuhan, Hubei 430074
China

Yongman Lv

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Physical Examination Center ( email )

Wuhan, Hubei
China

Yanjun Lu (Contact Author)

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Laboratory Medicine ( email )

Wuhan
China

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