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Atrophy in Midbrain & Cerebral/Cerebellar Pedunculi is Specific for Progressive Supranuclear Palsy - A Cross-Validation Whole-Brain Meta-Analysis

31 Pages Posted: 2 Nov 2018

See all articles by Franziska Albrecht

Franziska Albrecht

Max Planck Institute for Human Cognitive and Brain Sciences

Sandrine Bisenius

Max Planck Institute for Human Cognitive and Brain Sciences

Jane Neumann

Max Planck Institute for Human Cognitive and Brain Sciences

Jennifer L. Whitwell

Mayo Clinic - Department of Radiology

Matthias L. Schroeter

Max Planck Institute for Human Cognitive and Brain Sciences

More...

Abstract

Objective: Progressive supranuclear palsy (PSP) is an atypical parkinsonian syndrome characterized by vertical gaze palsy and postural instability. Midbrain atrophy is suggested as a hallmark, but it has not been validated systematically in whole-brain imaging.

Methods: We conducted whole-brain meta-analyses identifying disease-specific atrophy in structural MRI. Eighteen studies were identified (N=315 PSP, 393 controls) and separated into gray or white matter analyses (15/12). With overlay analyses, we cross-validated two meta-analytical algorithms: anatomical likelihood estimation and seed-based D mapping.

Results: Whole brain meta-analyses revealed consistent gray matter atrophy in bilateral thalamus, anterior insulae, midbrain, and left caudate nucleus. White matter alterations were consistently detected in bilateral superior/middle cerebellar pedunculi, cerebral pedunculi, and midbrain atrophy.

Conclusions: Our meta-analyses identify gray matter atrophy of the midbrain and white matter atrophy of the cerebral/cerebellar pedunculi and midbrain as specific to PSP. We support the incorporation of structural MRI data, and particularly these structures, into the revised PSP diagnostic criteria.

Keywords: Imaging biomarker, cerebral pedunculi, cerebellar pedunculi, meta-analysis, midbrain, progressive supranuclear palsy, anatomical likelihood estimation, seed-based D mapping

Suggested Citation

Albrecht, Franziska and Bisenius, Sandrine and Neumann, Jane and Whitwell, Jennifer L. and Schroeter, Matthias L., Atrophy in Midbrain & Cerebral/Cerebellar Pedunculi is Specific for Progressive Supranuclear Palsy - A Cross-Validation Whole-Brain Meta-Analysis (October 19, 2018). NICL-18-982, Available at SSRN: https://ssrn.com/abstract=3269800 or http://dx.doi.org/10.2139/ssrn.3269800

Franziska Albrecht (Contact Author)

Max Planck Institute for Human Cognitive and Brain Sciences ( email )

Leipzig
Germany

Sandrine Bisenius

Max Planck Institute for Human Cognitive and Brain Sciences ( email )

Leipzig
Germany

Jane Neumann

Max Planck Institute for Human Cognitive and Brain Sciences ( email )

Leipzig
Germany

Jennifer L. Whitwell

Mayo Clinic - Department of Radiology ( email )

200 First Street SW
Rochester, MN 55905
United States

Matthias L. Schroeter

Max Planck Institute for Human Cognitive and Brain Sciences ( email )

Leipzig
Germany

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