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Neurophysiological Markers of Network Dysfunction in Neurodegenerative Diseases

27 Pages Posted: 23 Oct 2018 First Look: Under Review

See all articles by Roisin McMackin

Roisin McMackin

Trinity College (Dublin) - Academic Unit of Neurology

Peter Bede

Trinity College (Dublin) - Academic Unit of Neurology

Niall Pender

Trinity College (Dublin) - Academic Unit of Neurology

Orla Hardiman

Trinity College (Dublin) - Academic Unit of Neurology

Bahman Nasseroleslami

Trinity College (Dublin) - Academic Unit of Neurology

Abstract

There is strong clinical, imaging and pathological evidence that neurodegeneration is associated with altered brain connectivity. While functional imaging (fMRI) can detect resting and activated states of metabolic activity, its use is limited by poor temporal resolution, cost and confounding vascular parameters. By contrast, electrophysiological (e.g. EEG/MEG) recordings provide direct measures of neural activity with excellent temporal resolution, and source localization methodologies can address problems of spatial resolution, permitting measurement of functional activity of brain networks with a spatial resolution similar to that of fMRI. This opens an exciting therapeutic approach focussed on pharmacological and physiological modulation of brain network activity. This review describes current neurophysiological approaches towards evaluating cortical network dysfunction in common neurodegenerative disorders. It explores how modern neurophysiologic tools can provide markers for diagnosis, prognosis, subcategorization and clinical trial outcome measures, and how modulation of brain networks can contribute to new therapeutic approaches.

Suggested Citation

McMackin, Roisin and Bede, Peter and Pender, Niall and Hardiman, Orla and Nasseroleslami, Bahman, Neurophysiological Markers of Network Dysfunction in Neurodegenerative Diseases (October 22, 2018). NICL-18-944, Available at SSRN: https://ssrn.com/abstract=3271290 or http://dx.doi.org/10.2139/ssrn.3271290

Roisin McMackin

Trinity College (Dublin) - Academic Unit of Neurology ( email )

Trinity College Dublin
52 - 160 Pearse St
Ireland

Peter Bede

Trinity College (Dublin) - Academic Unit of Neurology ( email )

Trinity College Dublin
52 - 160 Pearse St
Ireland

Niall Pender

Trinity College (Dublin) - Academic Unit of Neurology ( email )

Trinity College Dublin
52 - 160 Pearse St
Ireland

Orla Hardiman (Contact Author)

Trinity College (Dublin) - Academic Unit of Neurology ( email )

Trinity College Dublin
52 - 160 Pearse St
Ireland

Bahman Nasseroleslami

Trinity College (Dublin) - Academic Unit of Neurology

Trinity College Dublin
52 - 160 Pearse St
Ireland

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