A CRISPR-Cas9 Monograph: The Potency of Targeted Genome Modulation In Vivo

17 Pages Posted: 23 Nov 2018

See all articles by Thriaksh Rajan

Thriaksh Rajan

Rutgers University, New Brunswick - Rutgers Cancer Institute of New Jersey; Mount Sinai Health System - Icahn School of Medicine; Biotechnology High School

Date Written: April 20th, 2018

Abstract

In recent years, with the rise of numerous genetic disorders and autoimmune diseases, researchers have pioneered the CRISPR-Cas9 system as an economical, convenient, and scalable gene therapy treatment. Originally modeled, or identified, in Haloferax mediterranei by Francisco Mojica PhD at the University of Alicante in 1992, the CRISPR-Cas9 is effectively able to modify DNA in vivo. For example, studies abroad have selectively altered mutations in the MYBPC3 gene to help patients with embryonic hypertrophic cardiomyopathy. It is important to note that just as this system will largely impact the scientific community after its formal approval, so too will it affect much of the legislation, business, commerce, and lifestyle of the future. This monograph assesses the microscopic and macroscopic features of the CRISPR-Cas9 system meticulously by sequence analysis and literature review to determine the potential of this experimental field.

Keywords: Review, Genomics, CRISPR, Biochemistry, Molecular Biology, Oncology, Neuroscience, DNA

JEL Classification: I12

Suggested Citation

Rajan, Thriaksh, A CRISPR-Cas9 Monograph: The Potency of Targeted Genome Modulation In Vivo (April 20th, 2018). Available at SSRN: https://ssrn.com/abstract=3274863 or http://dx.doi.org/10.2139/ssrn.3274863

Thriaksh Rajan (Contact Author)

Rutgers University, New Brunswick - Rutgers Cancer Institute of New Jersey ( email )

195 Little Albany Street
New Brunswick, NJ 08903-2681
United States

HOME PAGE: http://cinj.org

Mount Sinai Health System - Icahn School of Medicine ( email )

One Gustave L. Levy Place
New York, NY 10029-6574
United States

HOME PAGE: http://mountsinai.org

Biotechnology High School ( email )

Freehold, NJ
United States

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