Individual Differences in the Antibody Response to Proteins of C57Bl/6J Mice
9 Pages Posted: 28 Nov 2018
Date Written: November 5, 2018
Male and female mice of the C57Bl/6J strain displayed large differences (large coefficients of variation) in the IgG antibody response to aggregated bovine serum albumin and keyhole limpet hemocyanin, for both primary and secondary responses. The scatter around the mean was not random, but somewhat ordered (as revealed by a large Kendall coefficient of concordance, for male antibody responses, or a moderate coefficient of concordance, for female responses). A hierarchical cluster analysis [by Ward's method, with differences in antibody content as distances (i.e. manhattan distances)], yielded several groups of (male or female) mice whose responses were of high, middle, or low magnitude. Those differences were not due to a litter effect, because some good antibody producers and some bad antibody producers belonged to the same litter.
Keywords: C57Bl/6J, IgG Antibody Response to Bovine Serum Albumin, IgG Antibody Response to Keyhole Limpet Hemocyanin
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