Overexpression of Human NPY or AgRP in the Paraventricular Nucleus Increase Bodyweight in Young Rhesus Macaques
20 Pages Posted: 14 Nov 2018 Sneak Peek Status: Under ReviewMore...
The role of neuropeptides agouti-related peptide (AgRP) and neuropeptide Y (NPY) in feeding behavior regulation have been extensively studied in rodents. However, the biological functions of these peptides in primates are not fully addressed. Here we shown that, through Lenti-virus mediated selective expression of human NPY (hNPY) or human AgRP (hAgRP) in the paraventricular nucleus (PVN), the bodyweight was significantly increased in young Rhesus Macaques. Whereas, the blood level of glucose and insulin, as well as metabolic parameters, including blood level of triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), non-esterified free fatty acids (NEFA) and leptin remain unchanged after virus injection. Although further investigations of long-term effects are needed, these results have recapitulated some parts of previous reports in rodents, and suggest that these non-germlines geneticlly modified monkeys may provide new models for studying feeding behaviors and related disease, such as obesity and diabetes.
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