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Shared Cortex-Cerebellum Dynamics in the Execution and Learning of a Motor Task

59 Pages Posted: 15 Nov 2018 Sneak Peek Status: Under Review

See all articles by Mark J. Wagner

Mark J. Wagner

Stanford University - Department of Biology; Stanford University, School of Humanities & Sciences, Department of Biology, Howard Hughes Medical Institute

Tony Hyun Kim

Stanford University - Department of Biology; Stanford University, School of Humanities & Sciences, Department of Biology, Howard Hughes Medical Institute; Stanford University - Department of Electrical Engineering

Jonathan Kadmon

Stanford University - Department of Applied Physics

Nghia D. Nguyen

Stanford University - Department of Biology; Stanford University, School of Humanities & Sciences, Department of Biology, Howard Hughes Medical Institute

Surya Ganguli

Stanford University - Department of Applied Physics

Mark J. Schnitzer

Stanford University - Department of Biology; Stanford University - Department of Applied Physics

Liqun Luo

Stanford University - Department of Biology; Stanford University, School of Humanities & Sciences, Howard Hughes Medical Institute, Department of Biology; Stanford University - Department of Bioengineering; Stanford University - Department of Applied Physics; Chan Zuckerberg Biohub

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Abstract

Throughout mammalian neocortex, layer 5 pyramidal cells (L5) project via the pons to a vast number of cerebellar granule cells (GCs), forming a fundamental pathway. Yet it is unknown how neuronal dynamics are transformed through the L5→GC pathway. Here, by directly comparing premotor L5 and GC activity during a forelimb movement task using dual-site two-photon Ca2 imaging, we found that in expert mice, L5 and GC dynamics were highly similar. L5 cells and GCs shared a common set of task-encoding activity patterns, possessed similar diversity of responses, and exhibited high L5-GC correlations comparable to local correlations among L5 cells. Chronic imaging revealed that these dynamics co-emerged in cortex and cerebellum over learning: as behavioral performance improved, L5 cells and GCs converged onto a shared, low-dimensional, task-encoding set of neural activity patterns. Thus, a key function of cortico-cerebellar communication is the propagation of shared dynamics that emerge during learning.

Suggested Citation

Wagner, Mark J. and Kim, Tony Hyun and Kadmon, Jonathan and Nguyen, Nghia D. and Ganguli, Surya and Schnitzer, Mark J. and Luo, Liqun, Shared Cortex-Cerebellum Dynamics in the Execution and Learning of a Motor Task (November 13, 2018). Available at SSRN: https://ssrn.com/abstract=3284449 or http://dx.doi.org/10.2139/ssrn.3284449
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Mark J. Wagner

Stanford University - Department of Biology ( email )

Gilbert Building, Rm 109
371 Serra Mall
Stanford, CA 94305
United States

Stanford University, School of Humanities & Sciences, Department of Biology, Howard Hughes Medical Institute ( email )

Stanford, CA 94305
United States

Tony Hyun Kim

Stanford University - Department of Biology ( email )

Gilbert Building, Rm 109
371 Serra Mall
Stanford, CA 94305
United States

Stanford University, School of Humanities & Sciences, Department of Biology, Howard Hughes Medical Institute ( email )

Stanford, CA 94305
United States

Stanford University - Department of Electrical Engineering ( email )

Stanford, CA 94305-6104
United States

Jonathan Kadmon

Stanford University - Department of Applied Physics ( email )

CA
United States

Nghia D. Nguyen

Stanford University - Department of Biology

Gilbert Building, Rm 109
371 Serra Mall
Stanford, CA 94305
United States

Stanford University, School of Humanities & Sciences, Department of Biology, Howard Hughes Medical Institute

Stanford, CA 94305
United States

Surya Ganguli

Stanford University - Department of Applied Physics ( email )

CA
United States

Mark J. Schnitzer

Stanford University - Department of Biology

Gilbert Building, Rm 109
371 Serra Mall
Stanford, CA 94305
United States

Stanford University - Department of Applied Physics ( email )

CA
United States

Liqun Luo (Contact Author)

Stanford University - Department of Biology ( email )

Gilbert Building, Rm 109
371 Serra Mall
Stanford, CA 94305
United States

Stanford University, School of Humanities & Sciences, Howard Hughes Medical Institute, Department of Biology ( email )

Stanford, CA
United States

Stanford University - Department of Bioengineering ( email )

Stanford, CA 94305
United States

Stanford University - Department of Applied Physics ( email )

CA
United States

Chan Zuckerberg Biohub

499 Illinois Street
San Francisco, CA 94158
United States

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