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Rod Photoreceptor Activation Alone Defines the Release of Dopamine in the Retina

36 Pages Posted: 15 Nov 2018 Sneak Peek Status: Under Review

See all articles by Víctor Pérez-Fernández

Víctor Pérez-Fernández

Western Sydney University - School of Medicine

Nina Milosavljevic

University of Manchester, Faculty of Biology, Medicine and Health, School of Biological Sciences, Department of Neuroscience and Experimental Psychology

Annette E. Allen

University of Manchester, Faculty of Biology, Medicine and Health, School of Biological Sciences, Department of Neuroscience and Experimental Psychology

Kirstan A. Vessey

University of Melbourne - Visual Neuroscience Laboratory

Andrew I. Jobling

University of Melbourne - Department of Anatomy and Neuroscience

Erica L. Fletcher

University of Melbourne - Department of Anatomy and Neuroscience

John W. Morley

Western Sydney University - School of Medicine

Morven Cameron

Western Sydney University - School of Medicine

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Abstract

Retinal dopamine is released by a specialised subset of amacrine cells in response to light and has a potent influence on how the retina responds to, and encodes, visual information. Here we address the critical question of which retinal photoreceptor is responsible for coordinating the release of this neuromodulator. While all three photoreceptor classes: rods, cones and melanopsin-containing retinal ganglion cells (mRGCs) have been shown to provide electrophysiological inputs to dopaminergic amacrine cells (DACs), we show here that the release of dopamine is defined only by rod photoreceptors. Remarkably, this rod signal coordinates both a suppressive signal at low intensities, and drives dopamine release at very bright light intensities. These data further reveal that dopamine release does not necessarily correlate with electrophysiological activity of dopaminergic amacrine cells and add to a growing body of evidence that rods define aspects of retinal function at very bright light levels.

Suggested Citation

Pérez-Fernández, Víctor and Milosavljevic, Nina and Allen, Annette E. and Vessey, Kirstan A. and Jobling, Andrew I. and Fletcher, Erica L. and Morley, John W. and Cameron, Morven, Rod Photoreceptor Activation Alone Defines the Release of Dopamine in the Retina (November 14, 2018). Available at SSRN: https://ssrn.com/abstract=3284451 or http://dx.doi.org/10.2139/ssrn.3284451
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Víctor Pérez-Fernández

Western Sydney University - School of Medicine

Building 30, Campbelltown campus
Narellan Road
Penrith NSW, 2751
Australia

Nina Milosavljevic

University of Manchester, Faculty of Biology, Medicine and Health, School of Biological Sciences, Department of Neuroscience and Experimental Psychology

Oxford Road
Manchester, M13 9PL
United Kingdom

Annette E. Allen

University of Manchester, Faculty of Biology, Medicine and Health, School of Biological Sciences, Department of Neuroscience and Experimental Psychology

Oxford Road
Manchester, M13 9PL
United Kingdom

Kirstan A. Vessey

University of Melbourne - Visual Neuroscience Laboratory

Melbourne, Victoria
Australia

Andrew I. Jobling

University of Melbourne - Department of Anatomy and Neuroscience

Melbourne, Victoria
Australia

Erica L. Fletcher

University of Melbourne - Department of Anatomy and Neuroscience

Melbourne, Victoria
Australia

John W. Morley

Western Sydney University - School of Medicine

Building 30, Campbelltown campus
Narellan Road
Penrith NSW, 2751
Australia

Morven Cameron (Contact Author)

Western Sydney University - School of Medicine ( email )

Building 30, Campbelltown campus
Narellan Road
Penrith NSW, 2751
Australia

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