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Interconnected Anatomical and Functional Brain Alterations in Children with Attention-Deficit/Hyperactivity Disorder

26 Pages Posted: 20 Nov 2018 First Look: Under Review

See all articles by Zhaomin Wu

Zhaomin Wu

Peking University - National Clinical Research Center for Mental Disorders

Alberto Llera

Radboud University Nijmegen - Donders Institute for Brain, Cognition and Behaviour

Martine Hoogman

Radboud University Nijmegen - Donders Institute for Brain, Cognition and Behaviour

Qing-Jiu Cao

Peking University - National Clinical Research Center for Mental Disorders

Marcel P. Zwiers

Radboud University Nijmegen - Donders Institute for Brain, Cognition and Behaviour

Janita Bralten

Radboud University Nijmegen - Donders Institute for Brain, Cognition and Behaviour

Li An

Peking University - National Clinical Research Center for Mental Disorders

Li Sun

Peking University - National Clinical Research Center for Mental Disorders

Li Yang

Peking University - National Clinical Research Center for Mental Disorders

Bin-Rang Yang

Shenzhen Children’s Hospital

Yu-Feng Zang

Hangzhou Normal University

Barbara Franke

Radboud University Nijmegen - Donders Institute for Brain, Cognition and Behaviour

Christian F. Beckmann

Radboud University Nijmegen - Donders Institute for Brain, Cognition and Behaviour

Maarten Mennes

Radboud University Nijmegen - Donders Institute for Brain, Cognition and Behaviour

Yu-Feng Wang

Peking University - National Clinical Research Center for Mental Disorders

Abstract

Neuroimaging studies have independently demonstrated brain anatomical and functional impairments in participants with ADHD. The aim of the current study was to explore the relationship between structural and functional brain alterations in ADHD through an integrated analysis of multimodal neuroimaging data.

Methods: We performed a multimodal analysis to integrate resting-state functional magnetic resonance imaging (MRI), structural MRI, and diffusion-weighted imaging data in a large, single-site sample of children with and without diagnosis for ADHD. The inferred subject contributions were fed into a regression models to investigate the relationships between diagnosis, symptom severity, gender, and age.

Results: Compared with controls, children with ADHD diagnosis showed altered white matter microstructure in widespread white matter fiber tracts as well as greater gray matter volume (GMV) in bilateral frontal regions, smaller GMV in posterior regions, and altered functional connectivity (FC) in default mode and fronto-parietal networks. Agerelated growth of GMV of bilateral occipital lobe, FC in frontal regions as well as age-related decline of GMV in medial regions seen in controls appeared reversed in children with ADHD. In the whole group, higher symptom severity was related to smaller GMV in widespread regions in bilateral frontal, parietal, and temporal lobes, as well as greater GMV in intracalcarine and temporal cortices.

Conclusions: Through a multimodel analysis approach we show that structural and functional alterations in brain regions known to be altered in subjects with ADHD from unimodal studies are linked across modalities. The brain alterations were related to clinical features of ADHD, including disorder status, age, and symptom severity.

Suggested Citation

Wu, Zhaomin and Llera, Alberto and Hoogman, Martine and Cao, Qing-Jiu and Zwiers, Marcel P. and Bralten, Janita and An, Li and Sun, Li and Yang, Li and Yang, Bin-Rang and Zang, Yu-Feng and Franke, Barbara and Beckmann, Christian F. and Mennes, Maarten and Wang, Yu-Feng, Interconnected Anatomical and Functional Brain Alterations in Children with Attention-Deficit/Hyperactivity Disorder (November 20, 2018). NICL-18-998. Available at SSRN: https://ssrn.com/abstract=3287719

Zhaomin Wu (Contact Author)

Peking University - National Clinical Research Center for Mental Disorders ( email )

No. 38 Xueyuan Road
Haidian District
Beijing, Beijing 100871
China

Alberto Llera

Radboud University Nijmegen - Donders Institute for Brain, Cognition and Behaviour ( email )

Montessorilaan 3
Nijmegen, 6525 HR
Netherlands

Martine Hoogman

Radboud University Nijmegen - Donders Institute for Brain, Cognition and Behaviour ( email )

Montessorilaan 3
Nijmegen, 6525 HR
Netherlands

Qing-Jiu Cao

Peking University - National Clinical Research Center for Mental Disorders

No. 38 Xueyuan Road
Haidian District
Beijing, Beijing 100871
China

Marcel P. Zwiers

Radboud University Nijmegen - Donders Institute for Brain, Cognition and Behaviour

Montessorilaan 3
Nijmegen, 6525 HR
Netherlands

Janita Bralten

Radboud University Nijmegen - Donders Institute for Brain, Cognition and Behaviour

Montessorilaan 3
Nijmegen, 6525 HR
Netherlands

Li An

Peking University - National Clinical Research Center for Mental Disorders

No. 38 Xueyuan Road
Haidian District
Beijing, Beijing 100871
China

Li Sun

Peking University - National Clinical Research Center for Mental Disorders

No. 38 Xueyuan Road
Haidian District
Beijing, Beijing 100871
China

Li Yang

Peking University - National Clinical Research Center for Mental Disorders

No. 38 Xueyuan Road
Haidian District
Beijing, Beijing 100871
China

Bin-Rang Yang

Shenzhen Children’s Hospital

Mintian Rd, FuTian CBD
Futian Qu
Shenzhen Shi, Guangdong Sheng 518026
China

Yu-Feng Zang

Hangzhou Normal University ( email )

Hangzhou Institute of Service Engineering, Hangzho
Hangzhou, Zhejiang 310036
China

Barbara Franke

Radboud University Nijmegen - Donders Institute for Brain, Cognition and Behaviour

Montessorilaan 3
Nijmegen, 6525 HR
Netherlands

Christian F. Beckmann

Radboud University Nijmegen - Donders Institute for Brain, Cognition and Behaviour

Montessorilaan 3
Nijmegen, 6525 HR
Netherlands

Maarten Mennes

Radboud University Nijmegen - Donders Institute for Brain, Cognition and Behaviour

Montessorilaan 3
Nijmegen, 6525 HR
Netherlands

Yu-Feng Wang

Peking University - National Clinical Research Center for Mental Disorders

No. 38 Xueyuan Road
Haidian District
Beijing, Beijing 100871
China

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