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Habitual Glucosamine Use is Associated with a Reduced Risk of Cardiovascular Disease, a Prospective Study in the UK Biobank

31 Pages Posted: 10 Dec 2018

See all articles by Hao Ma

Hao Ma

Tulane University - Department of Epidemiology

Xiang Li

Tulane University - Department of Epidemiology

Dianjianyi Sun

Tulane University - Department of Epidemiology

Tao Zhou

Tulane University - Department of Epidemiology

Sylvia H. Ley

Harvard University - Department of Nutrition

Jeanette Gustat

Tulane University - Department of Epidemiology

Yoriko Heianza

Tulane University - School of Public Health and Tropical Medicine

Lu Qi

Tulane University - Department of Epidemiology; Harvard University - Department of Nutrition

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Abstract

Background: Glucosamine is a common supplement for treating osteoarthritis, while its effectiveness on osteoarthritis and joint pain continues to be debated. Recently emerging evidence from animal studies and cross-sectional studies in humans suggest that glucosamine may have potential benefits on reduction of cardiovascular disease (CVD) and mortality; however, evidence from prospective studies is lacking.  

Methods: In the UK biobank cohort study, a total of 466,039 participants without CVD at baseline completed the questionnaire on supplement use, including glucosamine, were analyzed in this study. These participants were enrolled from 2006 to 2010 and followed up to 2016. Cox proportional hazards models were used to compare hazard ratios (HRs) and 95% confidence intervals (CIs) for incident CVD events in participants who did and did not use glucosamine.  

Findings: During a median of 7·0 years of follow-up, we documented 10,204 incident cases of CVD events, 3,060 cases of CVD death, 5,745 cases of CHD and 3,263 cases of stroke. After adjustment for age, sex, body mass index, race, lifestyle factors, dietary intakes, medication use and other supplements use, glucosamine use was associated with significantly reduced risks of total CVD events (HR: 0·85: 95% confidence interval [CI], 0·80-0·90), CVD death (HR: 0·78: 95% [CI], 0·70-0·87), CHD (HR: 0·82: 95% [CI], 0·76-0·88) and stroke (HR: 0·91: 95% [CI], 0·83-1·00). In addition, the associations of glucosamine use with risks of total CVD events and CHD were more pronounced in smokers than non-smokers (P-interaction=0·018 and 0·004, respectively).  

Interpretation: Beyond its original use for treating osteoarthritis, habitual use of glucosamine supplement was associated with significantly reduced risks of CVD events, especially among smokers. Further investigations in both prospective cohorts and clinical trials are warranted to verify our findings.  

Funding: The study was supported by grants from the National Heart, Lung, and Blood Institute (HL071981, HL034594, HL126024), the National Institute of Diabetes and Digestive and Kidney Diseases (DK115679, DK091718, DK100383, DK078616).

Declaration of Interest: We declare no competing interests.

Ethical Approval: All participants provided written informed consent and the study was approved by the NHS National Research Ethics Service. The present analysis was approved by the Tulane University (New Orleans, Louisiana) Institutional Review Board. Data from 502, 616 participants were available for our study.

Suggested Citation

Ma, Hao and Li, Xiang and Sun, Dianjianyi and Zhou, Tao and Ley, Sylvia H. and Gustat, Jeanette and Heianza, Yoriko and Qi, Lu, Habitual Glucosamine Use is Associated with a Reduced Risk of Cardiovascular Disease, a Prospective Study in the UK Biobank (November 30, 2018). Available at SSRN: https://ssrn.com/abstract=3296666

Hao Ma

Tulane University - Department of Epidemiology

New Orleans, LA 70112
United States

Xiang Li

Tulane University - Department of Epidemiology

New Orleans, LA 70112
United States

Dianjianyi Sun

Tulane University - Department of Epidemiology

New Orleans, LA 70112
United States

Tao Zhou

Tulane University - Department of Epidemiology

New Orleans, LA 70112
United States

Sylvia H. Ley

Harvard University - Department of Nutrition

Boston, MA 02115
United States

Jeanette Gustat

Tulane University - Department of Epidemiology

New Orleans, LA 70112
United States

Yoriko Heianza

Tulane University - School of Public Health and Tropical Medicine

New Orleans, LA 70112
United States

Lu Qi (Contact Author)

Tulane University - Department of Epidemiology

New Orleans, LA 70112
United States

Harvard University - Department of Nutrition

Boston, MA 02115
United States

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