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Associations of Physical Activity and Screen Time with White Matter Microstructure in Children from the General Population

24 Pages Posted: 18 Dec 2018

See all articles by María Rodriguez-Ayllon

María Rodriguez-Ayllon

University of Granada

Ivonne Derks

Erasmus University Rotterdam (EUR) - Erasmus Medical Center (MC)

Michiel van den Dries

Erasmus University Rotterdam (EUR) - Erasmus Medical Center (MC)

Irene Esteban Cornejo

University of Granada

Jeremy A. Labrecque

Erasmus University Rotterdam (EUR) - Erasmus Medical Center (MC)

Junwen Yang-Huang

Erasmus University Rotterdam (EUR) - Erasmus Medical Center (MC)

Hein Raat

Erasmus University Rotterdam (EUR) - Erasmus Medical Center (MC)

Meike W. Vernooij

Erasmus University Rotterdam (EUR) - Department of Epidemiology

Tonya White

Erasmus University Rotterdam (EUR) - Erasmus Medical Center (MC)

Francisco B. Ortega

University of Granada

Henning Tiemeier

Erasmus University Rotterdam (EUR) - Department of Child & Adolescent Psychiatry

Ryan L. Muetzel

Erasmus University Rotterdam (EUR) - Erasmus Medical Center (MC)

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Abstract

Background: Physical activity and sedentary behaviors have been linked to a variety of general health benefits and problems. However, few studies have examined how physical activity during childhood is related to brain development, with the majority of work to date focusing on cardio-metabolic health. This study examines the association between physical activity and screen time with white matter microstructure in the general pediatric population.

Methods: In a sample of 2,532 children (10.12 ± 0.58 years; 50.04% boys) from the Generation R Study, a population-based cohort in Rotterdam, the Netherlands, we assessed physical activity and screen time using parentreported questionnaires. Magnetic resonance imaging of white matter microstructure was conducted using diffusion tensor imaging.

Findings: Total physical activity was positively associated with global factional anisotropy (β=0.057, 95% CI= 0.016, 0.098, p=0.007) and negatively associated with global mean diffusivity (β=-0.079, 95% CI= - 0.120, -0.038, p<0.001), two commonly derived scalar measures of white matter microstructure. Two components of total physical activity, outdoor play and sport participation, were positively associated with global fractional anisotropy (β=0.041, 95% CI=(0.000, 0.083), p=0.047; β=0.053, 95% CI=(0.010, 0.096), p=0.015 respectively) and inversely associated with global mean diffusivity (β=-0.074, 95% CI= (-0.114, -0.033), p<0.001; β=-0.043, 95% CI=(-0.086, 0.000), p=0.049 respectively). No associations were observed between screen time and white matter microstructure (p>0.05).

Interpretation: This study provides new evidence that physical activity is modestly associated with white matter microstructure in children. In contrast, screen time was not associated with white matter microstructure. Causal inferences from these modest associations must be interpreted cautiously in the absence of longitudinal data. However, these data still offer a promising avenue for future work to explore to what extent physical activity may promote healthy white matter development.

Funding Statement: The Sophia Foundation (S18-20 awarded to RM) and Netherlands Organization for Health Research and Development (ZonMw) (project 016.VICI.170.200, awarded to HT and TOP 91211021, awarded to TW).

Declaration of Interests: The authors report no biomedical financial interests or potential conflicts of interest.

Ethics Approval Statement: The Medical Ethics Committee of the Erasmus Medical Center approved the study procedures and participants provided written informed consent.

Keywords: MRI, brain development, physical exercise

Suggested Citation

Rodriguez-Ayllon, María and Derks, Ivonne and van den Dries, Michiel and Esteban Cornejo, Irene and Labrecque, Jeremy A. and Yang-Huang, Junwen and Raat, Hein and Vernooij, Meike W. and White, Tonya and Ortega, Francisco B. and Tiemeier, Henning and Muetzel, Ryan L., Associations of Physical Activity and Screen Time with White Matter Microstructure in Children from the General Population (December 13, 2018). Available at SSRN: https://ssrn.com/abstract=3301634 or http://dx.doi.org/10.2139/ssrn.3301634

María Rodriguez-Ayllon

University of Granada

C/Rector López Argueta S/N
Granada, Granada 18071
Spain

Ivonne Derks

Erasmus University Rotterdam (EUR) - Erasmus Medical Center (MC)

Doctor Molewaterplein 40
Rotterdam, South Holland 3015 GD
Netherlands

Michiel Van den Dries

Erasmus University Rotterdam (EUR) - Erasmus Medical Center (MC)

Doctor Molewaterplein 40
Rotterdam, South Holland 3015 GD
Netherlands

Irene Esteban Cornejo

University of Granada

C/Rector López Argueta S/N
Granada, Granada 18071
Spain

Jeremy A. Labrecque

Erasmus University Rotterdam (EUR) - Erasmus Medical Center (MC)

Doctor Molewaterplein 40
Rotterdam, South Holland 3015 GD
Netherlands

Junwen Yang-Huang

Erasmus University Rotterdam (EUR) - Erasmus Medical Center (MC)

Doctor Molewaterplein 40
Rotterdam, South Holland 3015 GD
Netherlands

Hein Raat

Erasmus University Rotterdam (EUR) - Erasmus Medical Center (MC)

Doctor Molewaterplein 40
Rotterdam, South Holland 3015 GD
Netherlands

Meike W. Vernooij

Erasmus University Rotterdam (EUR) - Department of Epidemiology

Rotterdam
Netherlands

Tonya White

Erasmus University Rotterdam (EUR) - Erasmus Medical Center (MC)

Doctor Molewaterplein 40
Rotterdam, South Holland 3015 GD
Netherlands

Francisco B. Ortega

University of Granada

C/Rector López Argueta S/N
Granada, Granada 18071
Spain

Henning Tiemeier (Contact Author)

Erasmus University Rotterdam (EUR) - Department of Child & Adolescent Psychiatry ( email )

Postbus 2040
Rotterdam, 3000 CA
Netherlands

Ryan L. Muetzel

Erasmus University Rotterdam (EUR) - Erasmus Medical Center (MC)

Doctor Molewaterplein 40
Rotterdam, South Holland 3015 GD
Netherlands

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