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Epidemiological Characteristics of Subsyndromal Depression in Late Life

30 Pages Posted: 2 Jan 2019

See all articles by Dae Jong Oh

Dae Jong Oh

Seoul National University - Department of Psychiatry

Ji Won Han

Seoul National University - Department of Neuropsychiatry

Tae Hui Kim

Yonsei University

Kyung Phil Kwak

Dongguk University

Bong Jo Kim

Gyeongsang National University - College of Medicine

Shin Gyeom Kim

Soonchunhyang University - Bucheon Hospital

Jeong Lan Kim

Chungnam National University - School of Medicine

Seok Woo Moon

Konkuk University - School of Medicine

Joon Hyuk Park

Jeju National University

Seung-Ho Ryu

Konkuk University - School of Medicine

Jong Chul Youn

Kyunggi Provincial Hospital for the Elderly

Dong Young Lee

Seoul National University - Department of Psychiatry

Dong Woo Lee

Inje University - Sanggye Paik Hospital

Seok Bum Lee

Dankook University

Jung Jae Lee

Dankook University

Jin Hyeong Jhoo

Kangwon National University - College of Medicine

Ki Woong Kim

Seoul National University - Department of Psychiatry; Seoul National University - Department of Neuropsychiatry; Seoul National University - Department of Brain and Cognitive Sciences

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Abstract

Background: Subsyndromal depression is prevalent and associated with poor outcomes in late life, but its epidemiological characteristics have barely been investigated. The aim of this prospective cohort study is to compare the prevalence, incidence, and risk factors of subsyndromal depression with those of syndromal depression in community-dwelling elderly individuals.    

Methods: In a nationwide community-based study of randomly sampled Korean elderly population aged 60 years or older (N = 6,640), depression was assessed with standardized diagnostic interviews. At baseline and at 2-year and 4-year follow-ups, the authors diagnosed subsyndromal depression by the operational criteria and syndromal depression by the DSM-IV diagnostic criteria. Multivariate logistic regression analyses were conducted to identify the risk factors for incident depressive disorders.    

Outcomes: The age- and gender- adjusted prevalence rate of subsyndromal depression was 9·24% (95% CI = 8·54 – 9·93), which was 2·4-fold higher than that of syndromal depression. The incidence rate of subsyndromal depression was 21·70 per 1000 person-years (95% CI = 19·29 – 24·12), which was five-folds higher than that of syndromal depression. The prevalence to incidence ratio of subsyndromal depression was about half that of syndromal depression. The risk for subsyndromal depression was associated with female gender, low socioeconomic status, poor social support, and poor sleep quality while that of syndromal depression was associated with old age and less exercise.   

Interpretation: Subsyndromal depression should be validated as a clinical diagnostic entity, at least in late life, since it has epidemiological characteristics different from those of syndromal depression.    
Funding Statement: This study was supported by a grant from the Korean Health Technology R&D Project, Ministry for Health, Welfare, & Family Affairs, Republic of Korea (Grant No. A092077).

Declaration of Interests: The authors declare that there are no conflicts of interest.

Ethics Approval Statement: This study was approved by the Institutional Review Board of the Seoul National University Bundang Hospital.

Keywords: depression, subsyndromal depression, epidemiology, geriatric psychiatry

Suggested Citation

Oh, Dae Jong and Han, Ji Won and Kim, Tae Hui and Kwak, Kyung Phil and Kim, Bong Jo and Kim, Shin Gyeom and Kim, Jeong Lan and Moon, Seok Woo and Park, Joon Hyuk and Ryu, Seung-Ho and Youn, Jong Chul and Lee, Dong Young and Lee, Dong Woo and Lee, Seok Bum and Lee, Jung Jae and Jhoo, Jin Hyeong and Kim, Ki Woong, Epidemiological Characteristics of Subsyndromal Depression in Late Life (December 26, 2018). Available at SSRN: https://ssrn.com/abstract=3307657

Dae Jong Oh

Seoul National University - Department of Psychiatry

Seoul
Korea, Republic of (South Korea)

Ji Won Han

Seoul National University - Department of Neuropsychiatry

Seoul
Korea, Republic of (South Korea)

Tae Hui Kim

Yonsei University

Seoul
Korea, Republic of (South Korea)

Kyung Phil Kwak

Dongguk University

26 Pil-dong 3-ga
Jung-gu
Seoul, Seoul 100-715
Korea, Republic of (South Korea)

Bong Jo Kim

Gyeongsang National University - College of Medicine

Chinju City
Korea, Republic of (South Korea)

Shin Gyeom Kim

Soonchunhyang University - Bucheon Hospital

Korea, Republic of (South Korea)

Jeong Lan Kim

Chungnam National University - School of Medicine

Daejon, 35015
Korea, Republic of (South Korea)

Seok Woo Moon

Konkuk University - School of Medicine

Seoul 143-701, Korea
120 Neungdong-ro, Gwangjin-gu
Seoul 143-701, 143-701
Korea, Republic of (South Korea)

Joon Hyuk Park

Jeju National University

516-ro 2870
Jeju City, Jeju Special province 690-714
Korea, Republic of (South Korea)

Seung-Ho Ryu

Konkuk University - School of Medicine

Seoul 143-701, Korea
120 Neungdong-ro, Gwangjin-gu
Seoul 143-701, 143-701
Korea, Republic of (South Korea)

Jong Chul Youn

Kyunggi Provincial Hospital for the Elderly

Gyeonggido
Korea, Republic of (South Korea)

Dong Young Lee

Seoul National University - Department of Psychiatry

Seoul
Korea, Republic of (South Korea)

Dong Woo Lee

Inje University - Sanggye Paik Hospital

Gimhae
Korea, Republic of (South Korea)

Seok Bum Lee

Dankook University

126, Jukjeon-dong, Suji-gu, Yo
Gyeonggi-do
Korea, Republic of (South Korea)

Jung Jae Lee

Dankook University

126, Jukjeon-dong, Suji-gu, Yo
Gyeonggi-do
Korea, Republic of (South Korea)

Jin Hyeong Jhoo

Kangwon National University - College of Medicine

Chunchon
Korea, Republic of (South Korea)

Ki Woong Kim (Contact Author)

Seoul National University - Department of Psychiatry ( email )

Seoul
Korea, Republic of (South Korea)

Seoul National University - Department of Neuropsychiatry ( email )

Seoul
Korea, Republic of (South Korea)

Seoul National University - Department of Brain and Cognitive Sciences ( email )

Seoul, 08826
Korea, Republic of (South Korea)

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