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Prediction of Metabolic Syndrome for the Survival of Patients with Digestive Tract Cancer: A Meta-Analysis

25 Pages Posted: 2 Jan 2019

See all articles by Dan Hu

Dan Hu

Fujian Medical University

Meijin Zhang

Fujian Medical University - Department of Cardiology

Hejun Zhang

Fujian Medical University

Yan Xia

Fujian Medical University

Jinxiu Lin

Fujian Medical University

Xiongwei Zheng

Fujian Medical University

Feng Peng

Fujian Medical University - Department of Cardiology

Wenquan Niu

Government of the People's Republic of China - Institute of Clinical Medical Sciences

More...

Abstract

Backgrounds and Objectives: Growing evidence indicates that metabolic syndrome confers a differential risk for the development and progression of many types of cancer, especially at digestive tract system. We therefore synthesized the results of published cohort studies to test whether baseline metabolic syndrome and its components can predict survival outcomes in patients with esophageal, gastric or colorectal cancer.

Methods: Literature retrieval, publication selection and data extraction were performed independently and in duplicate. Data analyses were completed using STATA software, version 14.1.

Results: In total, 15 publications involving 54656 patients were meta-analyzed. In overall analyses, the presence of metabolic syndrome was associated with a non-significant 19% increased mortality risk in digestive tract cancer (95% confidence interval [CI]: 0.95 to 1.49, P=0.130). In stratified analyses, the association between metabolic syndrome and digestive tract cancer was statistically significant in prospective studies (effect size [ES]: 1.64, 95% CI: 1.18 to 2.28), in studies involving postsurgical patients (ES: 1.42, 95% CI: 1.06 to 1.92), and in studies assessing cancer-specific survival (ES: 0.93, 95% CI: 0.81 to 1.06). Further meta-regression analyses indicated that age and smoking were potential sources of between-study heterogeneity (both P<0.001). The shape of the Begg's funnel plot seemed symmetrical (Begg's test P=0.945 and Egger's test P=0.305).

Conclusions: Our meta-analytical findings indicate that metabolic syndrome was associated with an increased risk of postsurgical digestive tract cancer-specific mortality. Further validation and functional exploration are warranted.

Funding Statement: This study was supported by the Joint Funds for the Innovation of Science and Technology of Fujian Province (Grant No. 2017Y9090 and 2017Y9082), the Natural Science Foundation of Fujian Province (Grant No. 2018Y0024), the Fundamental Research Funds for the Central Universities (Grant No. 3332018170), and the Ministry of Health P.R. China (WKJ2016-2-05).

Declaration of Interests: The authors declare that they have no conflict of interest.

Ethics Approval Statement: This meta-analysis was conducted according to the guidelines in the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement.

Keywords: Digestive tract cancer; Metabolic syndrome; Meta-analysis; Survival; Prediction

Suggested Citation

Hu, Dan and Zhang, Meijin and Zhang, Hejun and Xia, Yan and Lin, Jinxiu and Zheng, Xiongwei and Peng, Feng and Niu, Wenquan, Prediction of Metabolic Syndrome for the Survival of Patients with Digestive Tract Cancer: A Meta-Analysis (December 24, 2018). Available at SSRN: https://ssrn.com/abstract=3307685

Dan Hu

Fujian Medical University

Fuzhou
China

Meijin Zhang

Fujian Medical University - Department of Cardiology

Fuzhou
China

Hejun Zhang

Fujian Medical University

Fuzhou
China

Yan Xia

Fujian Medical University

Fuzhou
China

Jinxiu Lin

Fujian Medical University

Fuzhou
China

Xiongwei Zheng

Fujian Medical University

Fuzhou
China

Feng Peng

Fujian Medical University - Department of Cardiology ( email )

Fuzhou
China

Wenquan Niu (Contact Author)

Government of the People's Republic of China - Institute of Clinical Medical Sciences ( email )

Beijing
China

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