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Alanine tRNA Translate Environment into Behavior in Caenorhabditis Elegans

70 Pages Posted: 29 Jan 2019 Sneak Peek Status: Review Complete

See all articles by Diana Andrea Fernandes De Abreu

Diana Andrea Fernandes De Abreu

Université Côte d'Azur - Genes, Environment, Plasticity

Thalia Salinas-Giegé

University of Strasbourg - Institute of Molecular Biology of Plants

Laurence Maréchal-Drouard

University of Strasbourg - Institute of Molecular Biology of Plants

Jean-Jacques Remy

Université Côte d'Azur - Genes, Environment, Plasticity

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Abstract

Caenorhabditis elegans nematodes produce and keep imprints of attractive chemosensory cues to which they are exposed early in life. These imprints enhance adult chemo-attraction to the same cues. Depending on the number of odor-exposed generations, imprinting is transiently or stably inherited.

Strinkingly, we have found that early odor-exposed C. elegans produce odor-specific forms of the transfer RNAAla (UGC). Naive animals fed on these tRNAs acquire transient or stable odor-specific imprinting.

The tRNAAla (UGC) controls C. elegans chemo-attractive responses through the multifunctional Elongator complex. Mutations that affect the functions of Elongator sub-units 1 or 3, either impaired chemo-attraction, or definitely abolish responses to the odors nematodes were exposed.

We hypothesize that early olfactory experiences translate into tRNAAla (UGC) bearing odor-specific signatures. These diffusible odor memory, together with Elongator, can stably reprogram the C. elegans chemo-attractive behavior.

Keywords: C. elegans chemosensory behavior, Olfactory imprinting, Odor-specific memory, Transfer RNA (tRNA), Elongator complex, Odor-specific anosmia, Chemoreceptors, Stable behavioral changes, Non-genetic inheritance

Suggested Citation

De Abreu, Diana Andrea Fernandes and Salinas-Giegé, Thalia and Maréchal-Drouard, Laurence and Remy, Jean-Jacques, Alanine tRNA Translate Environment into Behavior in Caenorhabditis Elegans (January 5, 2019). Available at SSRN: https://ssrn.com/abstract=3310818 or http://dx.doi.org/10.2139/ssrn.3310818
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Diana Andrea Fernandes De Abreu

Université Côte d'Azur - Genes, Environment, Plasticity

Sophia-Antipolis, 06903
France

Thalia Salinas-Giegé

University of Strasbourg - Institute of Molecular Biology of Plants

Strasbourg, F-67084
France

Laurence Maréchal-Drouard

University of Strasbourg - Institute of Molecular Biology of Plants

Strasbourg, F-67084
France

Jean-Jacques Remy (Contact Author)

Université Côte d'Azur - Genes, Environment, Plasticity ( email )

Sophia-Antipolis, 06903
France

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