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Altered Function of Superior Parietal Lobule Associated with Perceptive Awareness in First-Episode Drug-Naïve Panic Disorders

28 Pages Posted: 16 Jan 2019

See all articles by Haiyan Jin

Haiyan Jin

Shanghai Jiao Tong University (SJTU) - Shanghai Key Laboratory of Psychotic Disorders

Bin Zhang

Guangzhou Medical University - Affiliated Brain Hospital

Huiru Cui

Shanghai Jiao Tong University (SJTU) - Shanghai Key Laboratory of Psychotic Disorders

Wei Li

Shanghai Jiao Tong University (SJTU) - Shanghai Key Laboratory of Psychotic Disorders

Hui Li

Shanghai Jiao Tong University (SJTU) - Shanghai Key Laboratory of Psychotic Disorders

Qiang Hu

Shanghai Jiao Tong University (SJTU) - Shanghai Key Laboratory of Psychotic Disorders

Jijun Wang

Shanghai Jiao Tong University (SJTU) - Shanghai Key Laboratory of Psychotic Disorders

Chunbo Li

Shanghai Jiao Tong University (SJTU) - Shanghai Key Laboratory of Psychotic Disorders; Shanghai Jiao Tong University (SJTU)

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Abstract

Background: Biased perception plays an important role in the development and maintenance of panic disorder (PD), and high levels of cardiovascular symptoms in PD produce higher levels of heartbeat perception.

Methods: Currently, we investigated brain activity during interoceptive awareness in PD using functional MRI. We recruited 18 subjects with first-episode drug--naïve PD and 21 age- and gender-matched healthy controls (HCs).

Results: We found that the heartbeat perception scores (HPSs) were higher in individuals with PD than in HCs. When comparing greater heartbeats or greater puretones with fixation, PD patients showed higher activity in the bilateral superior parietal lobule (SPL) than HCs. Further, patients with PD exhibited a significant positive correlation between BOLD activity in the left SPL and HPS during the heartbeats vs. fixation condition and a positive correlation between BOLD activity in the right SPL and HPS, although this did not reach significance.

Interpretation: We identified impaired activation in the bilateral SPL during interoception and exteroception. The increased activation during interoceptive stimuli might render PD patients more engaged in processing information associated with their internal states, which may increase the probability of panic attacks. Our study provides insight regarding PD treatment, whereby inhibition of the SPL can be used to reduce cardiac interoceptive accuracy and relieve cardiac syndromes.

Funding Statement: This work was supported by grants from the National Natural Science Foundation of China (81071098), Shanghai Science and Technology Committee (15411950201, 15ZR1435500, 18ZR1432600, 18411952400), Shanghai Jiao Tong University Foundation (YG2016MS37), and Shanghai Municipal Commission of Health and Family Planning Foundation (20164Y0215).

Declaration of Interests: The Authors declare that there is no conflict of interest.

Ethics Approval Statement: This study was approved by the Research Ethics Committee at the SMHC, where the participants were recruited and assessed. All participants provided informed consent, and the consent was written in the study

Keywords: panic disorder, functional MRI, heartbeat, perception, interoception

Suggested Citation

Jin, Haiyan and Zhang, Bin and Cui, Huiru and Li, Wei and Li, Hui and Hu, Qiang and Wang, Jijun and Li, Chunbo, Altered Function of Superior Parietal Lobule Associated with Perceptive Awareness in First-Episode Drug-Naïve Panic Disorders (November 1, 2019). Available at SSRN: https://ssrn.com/abstract=3315799

Haiyan Jin

Shanghai Jiao Tong University (SJTU) - Shanghai Key Laboratory of Psychotic Disorders

Shanghai
China

Bin Zhang (Contact Author)

Guangzhou Medical University - Affiliated Brain Hospital ( email )

Mingxin Road #36
Guangzhou, 510370
United States

Huiru Cui

Shanghai Jiao Tong University (SJTU) - Shanghai Key Laboratory of Psychotic Disorders

Shanghai
China

Wei Li

Shanghai Jiao Tong University (SJTU) - Shanghai Key Laboratory of Psychotic Disorders

Shanghai
China

Hui Li

Shanghai Jiao Tong University (SJTU) - Shanghai Key Laboratory of Psychotic Disorders

Shanghai
China

Qiang Hu

Shanghai Jiao Tong University (SJTU) - Shanghai Key Laboratory of Psychotic Disorders

Shanghai
China

Jijun Wang

Shanghai Jiao Tong University (SJTU) - Shanghai Key Laboratory of Psychotic Disorders

Shanghai
China

Chunbo Li

Shanghai Jiao Tong University (SJTU) - Shanghai Key Laboratory of Psychotic Disorders ( email )

Shanghai
China

Shanghai Jiao Tong University (SJTU)

KoGuan Law School
Shanghai 200030, Shanghai 200052
China

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