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FASE-CPHG Study: A Panoramic Snapshot of Severe Asthma in French Non-Academic Hospitals

23 Pages Posted: 16 Jan 2019

See all articles by Laurent Portel

Laurent Portel

Centre Hospitalier de Libourne

Eric Parrat

Centre Hospitalier de Polynésie Française

Cécilia Nocent-Ejnaini

Centre Hospitalier de la Côte Basque

Gilles Mangiapan

Centre Hospitalier Intercommunal de Créteil

Anne Prud'homme

Centre Hospitalier Intercommunal de Bigorre

Jean-Philippe Oster

Centre Hospitalier Louis Pasteur

C. Aperre de Vecchi

Centre Hospitalier d’Argenteuil

C. Maurer

Groupe Hospitalier Intercommunal Le Raincy-Montfermeil

Chantal Raherison

Groupe Hospitalier Sud, Hôpital du Haut-Lévêque

Didier Debieuvre

Groupe Hospitalier de la Région Mulhouse Sud-Alsace

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Abstract

Background: Real-world data describing management of patients with severe asthma are limited. To address this issue, we conducted FASE-CPHG, a descriptive, multicentric, and observational cross-sectional study.

Methods: French pulmonologists from nonacademic hospitals completed questionnaires on patient characteristics and ongoing asthma treatment for severe asthmatic patients observed during the inclusion period. We also collected data from patients via self-assessment questionnaires.

Findings: A total of 104 physicians recruited 1502 patients within one year. The mean age of the 1465 patients analyzed was 54·4 ± 16·1 years. Severe asthmatic patients were more frequently female (62,6%), with a history of atopy (65%). Most patients remained poorly controlled or uncontrolled, with an important difference between physicians’ opinion and the GINA criteria (62,6% vs. 96% of patients). Most common comorbidities included ear, nose, and throat diseases (59% of cases); anxiety (39·5%); and gastro-esophageal reflux diseases (39·1%). Allergic sensitization tests and/or blood eosinophil count evaluation, and spirometry were performed in 92·1% and 98·2% of patients, respectively. The mean eosinophil count and total serum IgE were 437 mm3 and 546 UI/L, respectively. In addition to high doses of inhaled corticosteroids plus long-acting beta-2 agonists, 52·2% of patients were receiving leukotriene receptor antagonists, 34% anticholinergic drugs, 26·8% anti IgE, and 16·8% oral corticosteroids, while 65% adhered to their treatment.

Interpretation: This study provides insight into the characteristics and management of severe asthma in France and may help improve knowledge on this pathology, which represents a high burden to healthcare.

Funding Statement: ALK, AstraZeneca, Boehringer Ingelheim, GSK, Le Nouveau Souffle.

Declaration of Interests: "None"

Ethics Approval Statement: The study was approved by the local ethics committee (Comité Consultatif sur le Traitement de l’Information en matière de Recherche dans le domaine de la Santé) and was conducted according to the French law and guidelines on epidemiological and descriptive studies.

Keywords: severe asthma

Suggested Citation

Portel, Laurent and Parrat, Eric and Nocent-Ejnaini, Cécilia and Mangiapan, Gilles and Prud'homme, Anne and Oster, Jean-Philippe and de Vecchi, C. Aperre and Maurer, C. and Raherison, Chantal and Debieuvre, Didier, FASE-CPHG Study: A Panoramic Snapshot of Severe Asthma in French Non-Academic Hospitals (January 13, 2019). Available at SSRN: https://ssrn.com/abstract=3315852

Laurent Portel (Contact Author)

Centre Hospitalier de Libourne ( email )

Site Robert Boulin
Libourne
France

Eric Parrat

Centre Hospitalier de Polynésie Française

Hôpital du Taaone
Papeete
France

Cécilia Nocent-Ejnaini

Centre Hospitalier de la Côte Basque

Bayonne
France

Gilles Mangiapan

Centre Hospitalier Intercommunal de Créteil

Créteil
France

Anne Prud'homme

Centre Hospitalier Intercommunal de Bigorre

Tarbes
France

Jean-Philippe Oster

Centre Hospitalier Louis Pasteur

Colmar
France

C. Aperre De Vecchi

Centre Hospitalier d’Argenteuil

France

C. Maurer

Groupe Hospitalier Intercommunal Le Raincy-Montfermeil

France

Chantal Raherison

Groupe Hospitalier Sud, Hôpital du Haut-Lévêque

Pessac
France

Didier Debieuvre

Groupe Hospitalier de la Région Mulhouse Sud-Alsace

Mulhouse
France

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