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Synchronization and Spatial Patterning of Myosin Motors Regulates Oligodendrocyte Differentiation Speed

44 Pages Posted: 16 Jan 2019 Sneak Peek Status: Under Review

See all articles by Helena Sofia Domingues

Helena Sofia Domingues

International Iberian Nanotechnology Laboratory

Haibo Wang

Hunter College City University of New York - Department of Biological Sciences

Sandra Macedo-Ribeiro

Universidade do Porto - Instituto de Investigação e Inovação em Saúde - i3S; Universidade do Porto - Instituto de Biologia Molecular e Celular (IBMC)

Mateusz M. Urbanski

Hunter College City University of New York - Department of Biological Sciences

João Bettencourt Relvas

Universidade do Porto - Instituto de Investigação e Inovação em Saúde - i3S; Universidade do Porto - Instituto de Biologia Molecular e Celular (IBMC)

Boris Rubinstein

Stowers Institute for Medical Research

Carmen Melendez-Vasquez

Hunter College City University of New York - Department of Biological Sciences; CUNY - The Graduate Center

Inês Mendes Pinto

International Iberian Nanotechnology Laboratory

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Abstract

Oligodendrocytes are the central nervous system myelin-forming cells providing axonal electrical insulation and higher order neuronal circuitry. The mechanical forces driving oligodendrocyte precursor cells differentiation into myelinating oligodendrocytes are largely unknown but likely require the spatiotemporal regulation of the architecture and dynamics of the actin and actomyosin cytoskeletons. In this study, we explored the importance of the actomyosin cytoskeleton in developing oligodendrocytes and characterized the oligodendrocyte myosinome. We report that oligodendrocyte differentiation is regulated by the synchronized expression and non-uniform distribution of several members of the myosin network, particularly non-muscle myosins 2B and 2C, that potentially operate as nanomechanical modulators of cell tension and myelin membrane expansion at different cell stages.

Suggested Citation

Sofia Domingues, Helena and Wang, Haibo and Macedo-Ribeiro, Sandra and Urbanski, Mateusz M. and Bettencourt Relvas, João and Rubinstein, Boris and Melendez-Vasquez, Carmen and Mendes Pinto, Inês, Synchronization and Spatial Patterning of Myosin Motors Regulates Oligodendrocyte Differentiation Speed (January 16, 2019). Available at SSRN: https://ssrn.com/abstract=3316806 or http://dx.doi.org/10.2139/ssrn.3316806
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Helena Sofia Domingues

International Iberian Nanotechnology Laboratory

Avenida Mestre José Veiga s/n
Braga, 4715-330
Portugal

Haibo Wang

Hunter College City University of New York - Department of Biological Sciences

Room 927 Hunter North
695 Park Avenue
New York, NY 10065
United States

Sandra Macedo-Ribeiro

Universidade do Porto - Instituto de Investigação e Inovação em Saúde - i3S

Rua Alfredo Allen, 208
Porto
Portugal

Universidade do Porto - Instituto de Biologia Molecular e Celular (IBMC)

Porto
Portugal

Mateusz M. Urbanski

Hunter College City University of New York - Department of Biological Sciences

Room 927 Hunter North
695 Park Avenue
New York, NY 10065
United States

João Bettencourt Relvas

Universidade do Porto - Instituto de Investigação e Inovação em Saúde - i3S

Rua Alfredo Allen, 208
Porto
Portugal

Universidade do Porto - Instituto de Biologia Molecular e Celular (IBMC)

Porto
Portugal

Boris Rubinstein

Stowers Institute for Medical Research

1000 E 50th Street
Kansas City, MO 64110
United States

Carmen Melendez-Vasquez

Hunter College City University of New York - Department of Biological Sciences ( email )

Room 927 Hunter North
695 Park Avenue
New York, NY 10065
United States

CUNY - The Graduate Center ( email )

365 Fifth Avenue
New York,, NY 10016
United States

Inês Mendes Pinto (Contact Author)

International Iberian Nanotechnology Laboratory ( email )

Avenida Mestre José Veiga s/n
Braga, 4715-330
Portugal

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