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His 6-Metal Assemblies: A Novel and Promising Drug Delivery System

17 Pages Posted: 25 Jan 2019 First Look: Accepted

See all articles by Wenjuan Huang

Wenjuan Huang

Wenzhou Medical University - The Eye Hospital

Shan Luo

Wenzhou Medical University - The Eye Hospital

Tinghong Zhang

Chinese Academy of Sciences (CAS) - Wenzhou Institute of Biomaterials and Engineering; Chinese Academy of Sciences (CAS) - Engineering Research Center of Clinical Functional Materials and Diagnosis and Treatment Devices of Zhejiang Province

Bo Peng

Chinese Academy of Sciences (CAS) - Wenzhou Institute of Biomaterials and Engineering; Chinese Academy of Sciences (CAS) - Engineering Research Center of Clinical Functional Materials and Diagnosis and Treatment Devices of Zhejiang Province

Hao Chen

Wenzhou Medical University - The Eye Hospital

Xingjie Zan

Wenzhou Medical University - The Eye Hospital; Chinese Academy of Sciences (CAS) - Wenzhou Institute of Biomaterials and Engineering; Chinese Academy of Sciences (CAS) - Engineering Research Center of Clinical Functional Materials and Diagnosis and Treatment Devices of Zhejiang Province

Abstract

Constructing an ideal drug delivery system (i.e., high drug payload, low cytotoxicity, and rapid endocytosis and lysosome escape) under mild conditions is of great interest in disease treatment, tissue engineering, bioimaging, etc. Inspired by the coordinative interactions between histidine and metal ions, we present for the first time the facile synthesis of His6-metal assemblies (HmA) particles under mild conditions. The HmA particles presented a high loading capacity, a wide variety of loadable drugs, low cytotoxicity, quick internalization and lysosomal escape and rapid intracellular drug release. In addition, HmA encapsulation greatly improved the antitumor ability of camptothecin (CPT) relative to free CPT. By capitalizing on these promising features in drug delivery, HmA should have great potential in various biomedical fields.

Keywords: His-tag, Coordination polymer, Nanomedicine, Responsive release, Endocytosis

Suggested Citation

Huang, Wenjuan and Luo, Shan and Zhang, Tinghong and Peng, Bo and Chen, Hao and Zan, Xingjie, His 6-Metal Assemblies: A Novel and Promising Drug Delivery System (January 23, 2019). Available at SSRN: https://ssrn.com/abstract=3320742

Wenjuan Huang (Contact Author)

Wenzhou Medical University - The Eye Hospital

Wenzhou 325027
China

Shan Luo

Wenzhou Medical University - The Eye Hospital

Wenzhou 325027
China

Tinghong Zhang

Chinese Academy of Sciences (CAS) - Wenzhou Institute of Biomaterials and Engineering

52 Sanlihe Rd.
Datun Road, Anwai
Beijing, Xicheng District 100864
China

Chinese Academy of Sciences (CAS) - Engineering Research Center of Clinical Functional Materials and Diagnosis and Treatment Devices of Zhejiang Province

52 Sanlihe Rd.
Datun Road, Anwai
Beijing, Xicheng District 100864
China

Bo Peng

Chinese Academy of Sciences (CAS) - Wenzhou Institute of Biomaterials and Engineering

52 Sanlihe Rd.
Datun Road, Anwai
Beijing, Xicheng District 100864
China

Chinese Academy of Sciences (CAS) - Engineering Research Center of Clinical Functional Materials and Diagnosis and Treatment Devices of Zhejiang Province

52 Sanlihe Rd.
Datun Road, Anwai
Beijing, Xicheng District 100864
China

Hao Chen

Wenzhou Medical University - The Eye Hospital ( email )

Wenzhou 325027
China

Xingjie Zan

Wenzhou Medical University - The Eye Hospital

Wenzhou 325027
China

Chinese Academy of Sciences (CAS) - Wenzhou Institute of Biomaterials and Engineering

52 Sanlihe Rd.
Datun Road, Anwai
Beijing, Xicheng District 100864
China

Chinese Academy of Sciences (CAS) - Engineering Research Center of Clinical Functional Materials and Diagnosis and Treatment Devices of Zhejiang Province

52 Sanlihe Rd.
Datun Road, Anwai
Beijing, Xicheng District 100864
China

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