Dendritic Cells in the Host Response to Biomaterials and the Regulatory Pathway
40 Pages Posted: 28 Jan 2019 First Look: Accepted
Biomaterial-based strategies can significantly influence the treatment, prevention and diagnosis of multiple diseases. Despite the unprecedented success of biomaterials in addressing unmet biomedical needs and their applicability to personalized medicine, the clinical translation of these biomaterial systems is affected by the limited understanding of their interaction with complex host microenvironments. Biomaterials and biomedical devices implanted in the body may induce a highly complicated and orchestrated series of host responses. As macrophages are among the ﬁrst cells to infiltrate and respond to implanted biomaterials, the macrophage-mediated host response to biomaterials has been well studied. Dendritic cells (DCs) are the most potent antigen-presenting cells that activate naive T cells and bridge innate and adaptive immunity. The potential interaction of DCs with biomaterials appears to be critical for exerting the function of biomaterials and has become an important, developing area of investigation. Herein, we summarize the effects of the physicochemical properties of biomaterials on the immune function of DCs together with their receptors and signaling pathways. Knowledge of biomaterial-dendritic cell interactions can significantly facilitate clinical translation by guiding the design of biomaterials with particular effects on targeted cells, thus improving their clinical efficacy while minimizing undesired but predictable toxicological effects.
Keywords: Biomaterials, Dendritic Cells, Immune Function, Receptors, Signaling Pathway
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