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Stimulus-Responsive Polymeric Nanogels as Smart Drug Delivery Systems

44 Pages Posted: 1 Feb 2019 First Look: Accepted

See all articles by Navid Rabiee

Navid Rabiee

Sharif University of Technology - Department of Chemistry

Sakineh Hajebi

Sahand University of Technology - Department of Polymer Engineering; Sahand University of Technology - Institute of Polymeric Materials

Mojtaba Bagherzadeh

Sharif University of Technology - Department of Chemistry

Sepideh Ahmadi

Shahid Beheshti University of Medical Sciences - Department of Biotechnology

Mohammad Rabiee

Amirkabir University of Technology - Biomaterials Group

Hossein Roghani-Mamaqani

Sahand University of Technology - Department of Polymer Engineering; Sahand University of Technology - Institute of Polymeric Materials

Mohammadreza Tahriri

Marquette University - School of Dentistry

Lobat Tayebi

Marquette University - School of Dentistry

Michael R. Hamblin

Harvard University - Wellman Center for Photomedicine; Harvard University - Department of Dermatology; Massachusetts Institute of Technology (MIT) - Harvard-MIT Division of Health Sciences and Technology

Abstract

Nanogels are three-dimensional nanoscale networks formed by physically or chemically cross-linking polymers. Nanogels have been explored as drug delivery systems due to their advantageous properties, such as biocompatibility, high stability, tunable particle size, drug loading capacity, and possible modification of the surface for active targeting by attaching ligands that recognize cognate receptors on the target cells or tissues. Nanogels can be designed to be stimulus responsive, and react to internal or external stimuli such as pH, temperature, light, redox, thus resulting in the controlled release of loaded drug. This “smart” targeting ability prevents drug accumulation in non-target tissues and minimizes the side effects of the drug. This review aims to provide an introduction to nanogels, their preparation methods,and to discuss the design of various stimulus-responsive nanogels that are able to provide controlled drug release in response to particular stimuli.

Keywords: Nanogels, Stimulus-responsive, Drug delivery, Smart drug release, Cancer treatment

Suggested Citation

Rabiee, Navid and Hajebi, Sakineh and Bagherzadeh, Mojtaba and Ahmadi, Sepideh and Rabiee, Mohammad and Roghani-Mamaqani, Hossein and Tahriri, Mohammadreza and Tayebi, Lobat and Hamblin, Michael R., Stimulus-Responsive Polymeric Nanogels as Smart Drug Delivery Systems (February 1, 2019). Available at SSRN: https://ssrn.com/abstract=3326753

Navid Rabiee (Contact Author)

Sharif University of Technology - Department of Chemistry

Tehran
Iran

Sakineh Hajebi

Sahand University of Technology - Department of Polymer Engineering

Tabriz
Iran

Sahand University of Technology - Institute of Polymeric Materials

Tabriz
Iran

Mojtaba Bagherzadeh

Sharif University of Technology - Department of Chemistry

Tehran
Iran

Sepideh Ahmadi

Shahid Beheshti University of Medical Sciences - Department of Biotechnology

Velenjak Street, Shahid Chamran High Way
Tehran
Iran

Mohammad Rabiee

Amirkabir University of Technology - Biomaterials Group

P.O. Box 15875-4413
Tehran
Iran

Hossein Roghani-Mamaqani

Sahand University of Technology - Department of Polymer Engineering

Tabriz
Iran

Sahand University of Technology - Institute of Polymeric Materials

Tabriz
Iran

Mohammadreza Tahriri

Marquette University - School of Dentistry

P.O. Box 1881
Milwaukee, WI 53201-1881
United States

Lobat Tayebi

Marquette University - School of Dentistry

P.O. Box 1881
Milwaukee, WI 53201-1881
United States

Michael R. Hamblin

Harvard University - Wellman Center for Photomedicine ( email )

50 Blossom Street
Boston, MA 02114
United States

Harvard University - Department of Dermatology ( email )

MA
United States

Massachusetts Institute of Technology (MIT) - Harvard-MIT Division of Health Sciences and Technology ( email )

United States

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