From Tissues to Cell Types and Back: Single-Cell Gene Expression Analysis of Tissue Architecture

Posted: 6 Feb 2019

See all articles by Xi Chen

Xi Chen

Wellcome Genome Campus

Sarah A. Teichmann

Wellcome Genome Campus - Wellcome Sanger Institute

Kerstin Meyer

Wellcome Genome Campus

Date Written: July 2018

Abstract

With the recent transformative developments in single-cell genomics and, in particular, single-cell gene expression analysis, it is now possible to study tissues at the single-cell level, rather than having to rely on data from bulk measurements. Here we review the rapid developments in single-cell RNA sequencing (scRNA-seq) protocols that have the potential for unbiased identification and profiling of all cell types within a tissue or organism. In addition, novel approaches for spatial profiling of gene expression allow us to map individual cells and cell types back into the three-dimensional context of organs. The combination of in-depth single-cell and spatial gene expression data will reveal tissue architecture in unprecedented detail, generating a wealth of biological knowledge and a better understanding of many diseases.

Suggested Citation

Chen, Xi and Teichmann, Sarah A. and Meyer, Kerstin, From Tissues to Cell Types and Back: Single-Cell Gene Expression Analysis of Tissue Architecture (July 2018). Annual Review of Biomedical Data Science, Vol. 1, pp. 29-51, 2018, Available at SSRN: https://ssrn.com/abstract=3329803 or http://dx.doi.org/10.1146/annurev-biodatasci-080917-013452

Xi Chen (Contact Author)

Wellcome Genome Campus

Hinxton
Cambridge, England CB10 1SA
United Kingdom

Sarah A. Teichmann

Wellcome Genome Campus - Wellcome Sanger Institute

Hinxton
Cambridge, England CB10 1SA
United Kingdom

Kerstin Meyer

Wellcome Genome Campus ( email )

Hinxton
Cambridge, England CB10 1SA
United Kingdom

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