puc-header

Prefrontal Pathways Provide Top-Down Control of Memory for Sequences of Events

53 Pages Posted: 21 Feb 2019 Sneak Peek Status: Published

See all articles by Maanasa Jayachandran

Maanasa Jayachandran

Florida International University (FIU) - Cognitive Neuroscience Program

Stephanie B. Linley

Florida Atlantic University - Center for Complex Systems and Brain Sciences

Maximilian Schlecht

Florida International University (FIU) - Cognitive Neuroscience Program

Stephen V. Mahler

University of California, Irvine - Department of Neurobiology and Behavior

Robert P. Vertes

Florida Atlantic University - Center for Complex Systems and Brain Sciences

Timothy A. Allen

Florida International University (FIU) - Cognitive Neuroscience Program

More...

Abstract

We remember our lives as sequences of events, but it is unclear how these memories are controlled during retrieval. In rats, the prelimbic cortex (PL) is positioned to influence sequence memory through extensive top-down inputs to regions heavily interconnected with the hippocampus, notably the nucleus reuniens of the thalamus (RE) and perirhinal cortex (PER). Here we used an hM4Di synaptic-silencing approach to test our hypothesis that specific PL→RE and PL→PER projections regulate sequence memory retrieval. First, we found that suppressing PL activity impaired sequence memory. Second, we found that inhibiting PL→RE and PL→PER pathways effectively abolished sequence memory. Finally, we performed a sequential lag analysis showing that the PL→RE pathway contributes to a working memory retrieval strategy, whereas the PL→PER pathway contributes to a temporal context memory retrieval strategy. These findings demonstrate that the PL→RE and PL→PER pathways serve as top-down mechanisms that control sequence memory retrieval strategies.

Suggested Citation

Jayachandran, Maanasa and Linley, Stephanie B. and Schlecht, Maximilian and Mahler, Stephen V. and Vertes, Robert P. and Allen, Timothy A., Prefrontal Pathways Provide Top-Down Control of Memory for Sequences of Events (February 16, 2019). Available at SSRN: https://ssrn.com/abstract=3335778 or http://dx.doi.org/10.2139/ssrn.3335778
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Maanasa Jayachandran

Florida International University (FIU) - Cognitive Neuroscience Program

University Park
11200 SW 8th Street
Miami, FL 33199
United States

Stephanie B. Linley

Florida Atlantic University - Center for Complex Systems and Brain Sciences

777 Glades Road
Boca Raton, FL 33431
United States

Maximilian Schlecht

Florida International University (FIU) - Cognitive Neuroscience Program

University Park
11200 SW 8th Street
Miami, FL 33199
United States

Stephen V. Mahler

University of California, Irvine - Department of Neurobiology and Behavior

CA 92697
United States

Robert P. Vertes

Florida Atlantic University - Center for Complex Systems and Brain Sciences

777 Glades Road
Boca Raton, FL 33431
United States

Timothy A. Allen (Contact Author)

Florida International University (FIU) - Cognitive Neuroscience Program ( email )

University Park
11200 SW 8th Street
Miami, FL 33199
United States

Click here to go to Cell.com

Go to Cell.com

Paper statistics

Abstract Views
179
Downloads
8