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Intelligent Protein-Coated Bismuth Sulfide and Manganese Oxide Nanocomposites by Biomineralization for Multimodal Imaging-Guided Enhanced Tumor Therapy

27 Pages Posted: 25 Feb 2019 First Look: Preprint

See all articles by Lin Zhang

Lin Zhang

Soochow University - Department of Obstetrics and Gynecology

Qian Chen

Soochow University - Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices

Xinwei Zou

Soochow University - Department of Obstetrics and Gynecology

Jiawen Chen

Soochow University - Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices

Lvzhong Hu

Soochow University - Department of Obstetrics and Gynecology

Ziliang Dong

Soochow University - Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices

Jinhua Zhou

Soochow University - Department of Obstetrics and Gynecology

Youguo Chen

Soochow University - Department of Obstetrics and Gynecology

Zhuang Liu

Soochow University - Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices

Liang Cheng

Soochow University - Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices

Abstract

Radiotherapy (RT) has been used clinically to overcome cancer in recent decades. However, the abnormal tumor microenvironment (TME) featured with hypoxia, acidosis, and dense extracellular matrix is found to be related with the resistance of tumors to RT. Herein, intelligent bovine serum albumin (BSA)-coated Bi2S3 and MnO2 (Bi2S3-MnO2) nanocomposites synthesized by biomineralization are capable of modulating hypoxic TME effectively to enhance the efficacy of RT. After intravenous injection, the BSA-Bi2S3-MnO2 nanocomposites show efficient accumulation in tumor where endogenous H2O2 could be reacted with MnO2 to generate oxygen in-situ, leading to increased tumor oxygenation to overcome the hypoxia-associated resistance for RT. Moreover, the photothermal effect induced by BSA-Bi2S3-MnO2 nanocomposites further relieves the hypoxia in TME and finally synergistically improves RT effect. In this work, we present a simple strategy to fabricate intelligent therapeutic nanoparticles for improving therapeutic efficiency in cervical cancer.

Keywords: Biomineralization, Radiotherapy, Tumor microenvironment, Multimodal imaging, Combined therapy

Suggested Citation

Zhang, Lin and Chen, Qian and Zou, Xinwei and Chen, Jiawen and Hu, Lvzhong and Dong, Ziliang and Zhou, Jinhua and Chen, Youguo and Liu, Zhuang and Cheng, Liang, Intelligent Protein-Coated Bismuth Sulfide and Manganese Oxide Nanocomposites by Biomineralization for Multimodal Imaging-Guided Enhanced Tumor Therapy (February 22, 2019). Available at SSRN: https://ssrn.com/abstract=3339834

Lin Zhang

Soochow University - Department of Obstetrics and Gynecology

No. 1 Shizi Street
Taipei, Jiangsu 215006
Taiwan

Qian Chen

Soochow University - Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices

No. 1 Shizi Street
Taipei, Jiangsu 215006
Taiwan

Xinwei Zou

Soochow University - Department of Obstetrics and Gynecology

No. 1 Shizi Street
Taipei, Jiangsu 215006
Taiwan

Jiawen Chen

Soochow University - Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices

No. 1 Shizi Street
Taipei, Jiangsu 215006
Taiwan

Lvzhong Hu

Soochow University - Department of Obstetrics and Gynecology

No. 1 Shizi Street
Taipei, Jiangsu 215006
Taiwan

Ziliang Dong

Soochow University - Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices

No. 1 Shizi Street
Taipei, Jiangsu 215006
Taiwan

Jinhua Zhou

Soochow University - Department of Obstetrics and Gynecology

No. 1 Shizi Street
Taipei, Jiangsu 215006
Taiwan

Youguo Chen

Soochow University - Department of Obstetrics and Gynecology

No. 1 Shizi Street
Taipei, Jiangsu 215006
Taiwan

Zhuang Liu

Soochow University - Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices

No. 1 Shizi Street
Taipei, Jiangsu 215006
Taiwan

Liang Cheng (Contact Author)

Soochow University - Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices ( email )

No. 1 Shizi Street
Taipei, Jiangsu 215006
Taiwan

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