Limonia Acidissima Leaf Interceded Phytosynthesis of Iron Nanoparticles - A Latent Implement Against A549 Cell Lines

15 Pages Posted: 5 Mar 2019

See all articles by Sivapriya Veeraiyan

Sivapriya Veeraiyan

Bannari Amman Institute of Technology - Department of Biotechnology

Gayathri Suresh Kumar

Bannari Amman Institute of Technology - Department of Biotechnology

Pavithradevi Gunasekaran

Bannari Amman Institute of Technology - Department of Biotechnology

Sudarshana Deepa

Bannari Amman Institute of Technology - Department of Biotechnology

Date Written: February 27, 2019

Abstract

The main purpose of this study is to synthesize iron nanoparticles using the leaves of Limonia acidissima and establish a potential alternate form of sustained drug delivery system to treat lung cancer. The extract has been screened for phytochemicals and was analyzed by GCMS to determine the active phytoconstituents present in the extract. The synthesized iron nanoparticles were examined for surface morphology and functional groups by SEM and FTIR respectively. Free radical scavenging assay and cytotoxic activity for both the extract and nanoparticles were compared by DPPH and MTT assay against A549 Lung cancer cell lines. The enhancement of drug loading efficiency of synthesized iron nanoparticle using Limonia acidissima leaf extract was estimated to be 87.25 % and in vitro drug release studies revealed that the drug is released in a controlled and sustained mode. The Phyto synthesized iron nanoparticles exhibited 100% toxicity against A549 lung cancer cell line. This technique of biosynthesis of nano-materials using plant extract is a cost-effective and an easy approach to produce stable nanoparticles. Our research has demonstrated that nanoparticulate drug delivery system can serve as a potential alternate to various conventional methods that treat lung cancer.

Keywords: Limonia Acidissima, Iron Nanoparticles, Santalol, Beta-Rotunol, Lung Cancer, Limonia Assidicima, Iron Nanoparticles, A549 Cell Line

Suggested Citation

Veeraiyan, Sivapriya and Suresh Kumar, Gayathri and Gunasekaran, Pavithradevi and Deepa, Sudarshana, Limonia Acidissima Leaf Interceded Phytosynthesis of Iron Nanoparticles - A Latent Implement Against A549 Cell Lines (February 27, 2019). Available at SSRN: https://ssrn.com/abstract=3342984 or http://dx.doi.org/10.2139/ssrn.3342984

Sivapriya Veeraiyan (Contact Author)

Bannari Amman Institute of Technology - Department of Biotechnology ( email )

India

Gayathri Suresh Kumar

Bannari Amman Institute of Technology - Department of Biotechnology ( email )

India

Pavithradevi Gunasekaran

Bannari Amman Institute of Technology - Department of Biotechnology ( email )

India

Sudarshana Deepa

Bannari Amman Institute of Technology - Department of Biotechnology ( email )

India

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