Function Prediction of Human Proteins Using Machine Learning Algorithms

4 Pages Posted: 11 Apr 2019

See all articles by Arun Vikram

Arun Vikram

National Institute of Technology

Anuj Singh

Kamla Nehru Institute of Technology

Arvind Kumar Tiwari

Kamla Nehru Institute of Technology

Sudhakar Tripathi

Rajkiya Engineering College

Date Written: March 11, 2019

Abstract

Due to the rapid pace of research, accumulation of biological data is happening at an overwhelming rate. Sophisticated computation techniques are required to extract the useful information from this enormous amount of protein data such that the knowledge is practically useful and easily interpretable. For instance, drug discoverers need biological or computational methods to predict the functions of proteins, responsible for various diseases in human body. Since traditional biological methods were time consuming and comparatively expensive, various computational methods have been introduced in the respective research areas. In this research, we have tried to generate machine learning models that predict the protein function of unknown proteins and analyse their performance to obtain a model with highest accuracy. Sequence annotations such as Molecule Processing, Amino Acid modifications and other structural features like Active Site, Beta strand, Chain, etc. along with protein mass and length have been considered for prediction of protein functions. Feature selection has been performed in order to further improve the accuracy. Classification of proteins into 6 groups has been done according to the enzyme nomenclature scheme.

Keywords: Genomics, Machine Learning, Predictive Analytics, Drug Discovery

Suggested Citation

Vikram, Arun and Singh, Anuj and Tiwari, Arvind Kumar and Tripathi, Sudhakar, Function Prediction of Human Proteins Using Machine Learning Algorithms (March 11, 2019). Proceedings of 2nd International Conference on Advanced Computing and Software Engineering (ICACSE) 2019. Available at SSRN: https://ssrn.com/abstract=3350256 or http://dx.doi.org/10.2139/ssrn.3350256

Arun Vikram (Contact Author)

National Institute of Technology ( email )

Patna
India

Anuj Singh

Kamla Nehru Institute of Technology ( email )

SULTANPUR
UTTAR PRADESH
SULTANPUR
India

Arvind Kumar Tiwari

Kamla Nehru Institute of Technology ( email )

SULTANPUR
UTTAR PRADESH
SULTANPUR
India

Sudhakar Tripathi

Rajkiya Engineering College ( email )

Ambedkar Nagar
India

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