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IoT PCR for Pandemic Disease Detection and Its Spread Monitoring

21 Pages Posted: 19 Mar 2019

See all articles by Hanliang Zhu

Hanliang Zhu

Northwestern Polytechnical University, China - Key Laboratory of Micro/Nano Systems for Aerospace

Pavel Podesva

Northwestern Polytechnical University, China - Key Laboratory of Micro/Nano Systems for Aerospace

Xiaocheng Liu

Northwestern Polytechnical University, China - Key Laboratory of Micro/Nano Systems for Aerospace

Haoqing Zhang

Northwestern Polytechnical University, China - Key Laboratory of Micro/Nano Systems for Aerospace

Tomas Teply

Czech Technical University

Ying Xu

Northwestern Polytechnical University, China - Key Laboratory of Micro/Nano Systems for Aerospace

Honglong Chang

Northwestern Polytechnical University, China - Key Laboratory of Micro/Nano Systems for Aerospace

Airong Qian

Northwestern Polytechnical University, China - Key Laboratory of Micro/Nano Systems for Aerospace

Yingfeng Lei

Air Force Military Medical University

Yu Li

Air Force Military Medical University

Andreea Niculescu

Agency for Science, Technology and Research (A*STAR) - Institute for Infocomm Research

Ciprian Iliescu

National University of Singapore (NUS)

Pavel Neuzil

Northwestern Polytechnical University, China - Key Laboratory of Micro/Nano Systems for Aerospace

More...

Abstract

During infectious diseases outbreaks, the centers for disease control need to monitor particular areas. Considerable effort has been invested into the development of portable, user-friendly and cost-effective systems for point-of-care (POC) diagnostics. Connecting these systems via a mobile network would create an 'internet of things' (IoT) for healthcare, an essential tool helping to tackle infectious disease outbreaks. However, at present IoT based on a functional POC instrument is not available. Here we show fast, user-friendly, and affordable IoT system based on a miniaturized polymerase chain reaction device. We demonstrated the system's capability to detect and monitor the spread of infectious diseases, here using mosquito born dengue fever virus (DENV).  We demonstrated the system's capability by amplification of either complementary deoxyribonucleic acid or ribonucleic acid of the DENV. The result data were then automatically uploaded via a Bluetooth interface to an Android-based smartphone and further wirelessly sent to global network, instantly making the test results available anywhere in the world. The IoT system presented here could become an essential tool for healthcare centers to help tackle infectious disease outbreaks identified either by DNA or RNA. Its use can be of side scope, since it can be modified to be compatible with other sensing methods.

Funding Statement: Hanliang Zhu, Pavel Podesva, Xiaocheng Liu, Haoqing Zhang, Ying Xu, Honglong Chang, and Pavel Neuzil would like to acknowledge financial support from the Foreign Expert Plan #W0990109 and the help of technicians from the cleanroom at Northwestern Polytechnical University, Xi’an, P.R. China for the fabrication of chips used for this work.

Declaration of Interests: Authors declare no competing interests.

Keywords: Infectious disease control, RNA/DNA detection, Internet of Things

Suggested Citation

Zhu, Hanliang and Podesva, Pavel and Liu, Xiaocheng and Zhang, Haoqing and Teply, Tomas and Xu, Ying and Chang, Honglong and Qian, Airong and Lei, Yingfeng and Li, Yu and Niculescu, Andreea and Iliescu, Ciprian and Neuzil, Pavel, IoT PCR for Pandemic Disease Detection and Its Spread Monitoring (December 3, 2019). Available at SSRN: https://ssrn.com/abstract=3352008 or http://dx.doi.org/10.2139/ssrn.3352008

Hanliang Zhu

Northwestern Polytechnical University, China - Key Laboratory of Micro/Nano Systems for Aerospace ( email )

127# YouYi Load
XiAn, Shaanxi 710072
China

Pavel Podesva

Northwestern Polytechnical University, China - Key Laboratory of Micro/Nano Systems for Aerospace ( email )

127# YouYi Load
XiAn, Shaanxi 710072
China

Xiaocheng Liu

Northwestern Polytechnical University, China - Key Laboratory of Micro/Nano Systems for Aerospace ( email )

127# YouYi Load
XiAn, Shaanxi 710072
China

Haoqing Zhang

Northwestern Polytechnical University, China - Key Laboratory of Micro/Nano Systems for Aerospace ( email )

127# YouYi Load
XiAn, Shaanxi 710072
China

Tomas Teply

Czech Technical University ( email )

Zikova 1903/4 166 36 Praha 6
Prague
Czech Republic

Ying Xu

Northwestern Polytechnical University, China - Key Laboratory of Micro/Nano Systems for Aerospace ( email )

127# YouYi Load
XiAn, Shaanxi 710072
China

Honglong Chang

Northwestern Polytechnical University, China - Key Laboratory of Micro/Nano Systems for Aerospace ( email )

127# YouYi Load
XiAn, Shaanxi 710072
China

Airong Qian

Northwestern Polytechnical University, China - Key Laboratory of Micro/Nano Systems for Aerospace ( email )

127# YouYi Load
XiAn, Shaanxi 710072
China

Yingfeng Lei

Air Force Military Medical University ( email )

169 Changle West Road
Xi'an, Shaanxi 710032
China

Yu Li

Air Force Military Medical University ( email )

169 Changle West Road
Xi'an, Shaanxi 710032
China

Andreea Niculescu

Agency for Science, Technology and Research (A*STAR) - Institute for Infocomm Research ( email )

1 Fusionopolis Way
#16-16 Connexis
Singapore, 138632
Singapore

Ciprian Iliescu

National University of Singapore (NUS) ( email )

1E Kent Ridge Road
NUHS Tower Block Level 7
Singapore, 119228
Singapore

Pavel Neuzil (Contact Author)

Northwestern Polytechnical University, China - Key Laboratory of Micro/Nano Systems for Aerospace ( email )

127# YouYi Load
XiAn, Shaanxi 710072
China

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