Download This Paper
Preprints with The Lancet is a collaboration between The Lancet Group of journals and SSRN to facilitate the open sharing of preprints for early engagement, community comment, and collaboration. Preprints available here are not Lancet publications or necessarily under review with a Lancet journal. These preprints are early-stage research papers that have not been peer-reviewed. The usual SSRN checks and a Lancet-specific check for appropriateness and transparency have been applied. The findings should not be used for clinical or public health decision-making or presented without highlighting these facts. For more information, please see the FAQs.
Health-Related Quality of Life of Type 2 Diabetes Inpatients with Diabetes-Related Complications in China
27 Pages Posted: 23 Mar 2019
More...
There are 2 versions of this paper
Health-Related Quality of Life of Type 2 Diabetes Inpatients with Diabetes-Related Complications in China
Abstract
Background: Quite a few studies have evaluated the health-related quality of life (HRQOL) of type 2 diabetes (T2DM) patients, but few focused on inpatients with diabetes-related complications in relative serious condition. Reliable estimates of the impact of complications on HRQOL are important to understand the disease burden and serve for economic evaluation. This study aims to estimate the utility-based HRQOL of T2DM inpatients with complications in China, and quantify the utility decrement due to a certain complication.
Methods: This is a cross-sectional study. T2DM inpatients being hospitalized for their complications, including ischemic heart disease (IHD), acute myocardial infarction (AMI), congestive heart failure (CHF), stroke, low vision (LV), end-stage renal disease (ESRD), ulcer or amputation; and T2DM outpatients without complications were recruited from a tertiary hospital in China during January to May 2017. EuroQOL 5-dimensions 3-level instrument was administered to these patients through face-to-face interviews. Socio-demographic and disease-specific data were collected from the survey. One-way analysis of variance and multiple linear regression analysis were performed.
Findings 802 inpatients with complications (mean age: 62·67 years, female proportion: 43%) and 66 outpatients without complications (mean age: 46·52 years, female proportion: 50%) were included. Mean utility-based HRQOL was 0·923 for patients without complications, while 0·562 for inpatients with a certain complication. Utility significantly varied between complications: IHD=0·620, AMI=0·434, CHF=0·471, stroke=0·472, LV=0·714, ESRD=0·693, ulcer=0·431, amputation=0·395. Regression results showed that utility decrement associated with IHD was 0·269, AMI=0·460, CHF=0·399, stroke=0·413, LV=0·174, ESRD=0·192, ulcer=0·444, amputation=0·489.
Interpretation: HRQOL of T2DM inpatients with complication was considerable impaired. Inpatients with amputation were associated with the greatest utility decrement, followed by AMI and ulcer.
Funding: No funding was received for this study.
Declaration of Interest: No potential conflicts of interest were reported.
Ethical Approval: The study was reviewed and approved by the Medical Faculty Ethics Committee of Zhejiang University.
Keywords: Health-Related Quality of Life; Type 2 Diabetes; Inpatients; Diabetes-Related Complications; China; cross-sectional study; utility; EQ-5D; ischemic heart disease; acute myocardial infarction; congestive heart failure; stroke; low vision; end-stage renal disease; ulcer; amputation
Suggested Citation: Suggested Citation