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Opposing Contributions of GABAergic and Glutamatergic Ventral Pallidal Neurons to Motivational Behaviours

53 Pages Posted: 9 Apr 2019 Sneak Peek Status: Under Review

See all articles by Marcus Stephenson-Jones

Marcus Stephenson-Jones

Cold Spring Harbor Laboratory

Christian Bravo-Rivera

Cold Spring Harbor Laboratory

Sandra Ahrens

Cold Spring Harbor Laboratory - The Stanley Institute for Cognitive Genomics

Alessandro Furlan

Cold Spring Harbor Laboratory

Carolina Fernandes-Henriques

Cold Spring Harbor Laboratory

Bo Li

Cold Spring Harbor Laboratory

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Abstract

The ventral pallidum (VP) is critical for invigorating reward seeking and is also involved in punishment avoidance, but how it contributes to such opposing behavioural actions remains unclear. Here we show that GABAergic and glutamatergic VP neurons selectively control behaviour in opposing motivational contexts. In vivo recording combined with optogenetics in mice revealed that these two populations oppositely encode positive and negative motivational value, are differentially modulated by animal’s internal state and determine the behavioural response during motivational conflict. Furthermore, GABAergic VP neurons are essential for movements towards reward in a positive motivational context, but suppress movements in an aversive context. In contrast, glutamatergic VP neurons are essential for movements to avoid a threat but suppress movements in an appetitive context. Our results indicate that GABAergic and glutamatergic VP neurons encode the drive for approach and avoidance, respectively, with the balance between their activities determining the type of motivational behaviour.

Keywords: ventral pallidum, motivation, GABAergic neurons, glutamatergic neurons, reward seeking, punishment avoidance

Suggested Citation

Stephenson-Jones, Marcus and Bravo-Rivera, Christian and Ahrens, Sandra and Furlan, Alessandro and Fernandes-Henriques, Carolina and Li, Bo, Opposing Contributions of GABAergic and Glutamatergic Ventral Pallidal Neurons to Motivational Behaviours (April 5, 2019). Available at SSRN: https://ssrn.com/abstract=3367001 or http://dx.doi.org/10.2139/ssrn.3367001
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Marcus Stephenson-Jones

Cold Spring Harbor Laboratory ( email )

Cold Spring Harbor, NY 11724
United States

Christian Bravo-Rivera

Cold Spring Harbor Laboratory

Cold Spring Harbor, NY 11724
United States

Sandra Ahrens

Cold Spring Harbor Laboratory - The Stanley Institute for Cognitive Genomics

Cold Spring Harbor, NY 11724
United States

Alessandro Furlan

Cold Spring Harbor Laboratory

Cold Spring Harbor, NY 11724
United States

Carolina Fernandes-Henriques

Cold Spring Harbor Laboratory

Cold Spring Harbor, NY 11724
United States

Bo Li (Contact Author)

Cold Spring Harbor Laboratory

Cold Spring Harbor, NY 11724
United States

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