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Olfactory Identification in 7-Year-Old Children with Familial High Risk of Schizophrenia or Bipolar Disorder - The Danish High Risk and Resilience Study VIA 7

24 Pages Posted: 9 Apr 2019

See all articles by Anna Ver Loren van Themaat

Anna Ver Loren van Themaat

Child and Adolescent Mental Health Centre - Mental Health Services; University of Copenhagen - Department of Clinical Medicine; University of Copenhagen - Danish Research Centre Magnetic Resonance

Md Jamal Uddin

Mental Health Centre Copenhagen

Camilla Jerlang Christiani

Mental Health Centre Copenhagen

Nicoline Hemager

Child and Adolescent Mental Health Centre

Ditte Ellersgaard

Mental Health Centre Copenhagen

Birgitte Klee Burton

Child and Adolescent Mental Health Centre

Katrine Søborg Spang

Child and Adolescent Mental Health Centre

Aja Greve

Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH)

Ditte Gantriis

Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH)

Ole Mors

Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH)

Anne Amalie Elgaard Thorup

University of Copenhagen - Department of Clinical Medicine

Kerstin Jessica Plessen

Child and Adolescent Mental Health Centre - Mental Health Services

Merete Nordentoft

University of Copenhagen - Department of Clinical Medicine

Jens Richardt Møllegaard Jepsen

Child and Adolescent Mental Health Centre - Mental Health Services

More...

Abstract

Background: Olfactory identification deficits are present in individuals with schizophrenia and their unaffected first-degree relatives, while deficits are less pronounced in individuals with bipolar disorder. We hypothesized that children with familial high-risk for schizophrenia (FHR-SZ) show olfactory identification deficits compared to population-based controls (PBC), and that children with familial high-risk for bipolar disorder (FHR-BP) perform intermediate. Furthermore, we investigated potential relationships with psychopathology, cognition, and home environment.

Methods: Olfactory identification was assessed at age 7 in 184 children with FHR-SZ, 106 children with FHR-BD, and 186 PBC with the Brief Smell Identification Test (BSIT). BSIT total score and the proportion of children scoring below pre-defined cut-off scores were the outcomes. Potential relationships with psychopathological, cognitive, and home environmental variables were conducted using hierarchical and logistic multiple regression analyses.

Outcomes: ANOVA revealed no between-group differences in olfactory identification. Chi-square test of independence showed a significant greater proportion of boys with FHR-SZ than population-based boys with an abnormal olfactory identification (p<0·05). Regression analyses of all children showed significant positive associations of olfactory identification with girls, social responsiveness, and working memory. Less social responsiveness predicted abnormal olfactory identification in boys with FHR-SZ.

Interpretation: Abnormal olfactory identification is more frequent in 7-year-old boys with FHR-SZ than in matched low-risk boys and is linked to a deficit of social responsiveness. This supports the idea that olfactory and social dysfunction share a common pathophysiological and perhaps neurobiological pathway in schizophrenia.

Funding Statement: Mental Health Services of the Capital Region of Denmark, Aarhus University, and the Lundbeck Foundation Initiative for Integrative Psychiatric Research.

Declaration of Interests: All authors confirmed to have no conflicts of interest.

Ethics Approval Statement: The project was approved by The Danish Data Protection Agency. The study procedures were aligned with the guidelines of the National Committee for Health Research Ethics, although formal ethical approval was not required due to its observational design.

Suggested Citation

Ver Loren van Themaat, Anna and Uddin, Md Jamal and Christiani, Camilla Jerlang and Hemager, Nicoline and Ellersgaard, Ditte and Burton, Birgitte Klee and Spang, Katrine Søborg and Greve, Aja and Gantriis, Ditte and Mors, Ole and Thorup, Anne Amalie Elgaard and Plessen, Kerstin Jessica and Nordentoft, Merete and Jepsen, Jens Richardt Møllegaard, Olfactory Identification in 7-Year-Old Children with Familial High Risk of Schizophrenia or Bipolar Disorder - The Danish High Risk and Resilience Study VIA 7 (April 5, 2019). Available at SSRN: https://ssrn.com/abstract=3367056 or http://dx.doi.org/10.2139/ssrn.3367056

Anna Ver Loren van Themaat (Contact Author)

Child and Adolescent Mental Health Centre - Mental Health Services ( email )

Copenhagen
Denmark

University of Copenhagen - Department of Clinical Medicine ( email )

Nørregade 10
Copenhagen, København DK-1165
Denmark

University of Copenhagen - Danish Research Centre Magnetic Resonance ( email )

Copenhagen
Denmark

Md Jamal Uddin

Mental Health Centre Copenhagen

Copenhagen
Denmark

Camilla Jerlang Christiani

Mental Health Centre Copenhagen

Copenhagen
Denmark

Nicoline Hemager

Child and Adolescent Mental Health Centre

Copenhagen
Denmark

Ditte Ellersgaard

Mental Health Centre Copenhagen

Copenhagen
Denmark

Birgitte Klee Burton

Child and Adolescent Mental Health Centre

Copenhagen
Denmark

Katrine Søborg Spang

Child and Adolescent Mental Health Centre

Copenhagen
Denmark

Aja Greve

Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH)

Aarhus
Denmark

Ditte Gantriis

Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH)

Aarhus
Denmark

Ole Mors

Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH)

Aarhus
Denmark

Anne Amalie Elgaard Thorup

University of Copenhagen - Department of Clinical Medicine

Nørregade 10
Copenhagen, København DK-1165
Denmark

Kerstin Jessica Plessen

Child and Adolescent Mental Health Centre - Mental Health Services

Copenhagen
Denmark

Merete Nordentoft

University of Copenhagen - Department of Clinical Medicine

Nørregade 10
Copenhagen, København DK-1165
Denmark

Jens Richardt Møllegaard Jepsen

Child and Adolescent Mental Health Centre - Mental Health Services

Copenhagen
Denmark

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