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Aggregation-Induced Emission-Based Ionic Liquids for Bacterial Killing, Imaging, Cell Labelling and Bacterial Detection in Blood Cells

35 Pages Posted: 8 Apr 2019 First Look: Accepted

See all articles by Jie Shi

Jie Shi

Soochow University - Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application

Mengyao Wang

Soochow University - Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application

Zhe Sun

Soochow University - Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application

Yangyang Liu

Fudan University - Department of Anesthesiology and Critical Care Medicine

Jiangna Guo

Soochow University - Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application

Hailei Mao

Fudan University - Department of Anesthesiology and Critical Care Medicine

Feng Yan

Soochow University - Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application

Abstract

A series of aggregation-induced emission (AIE)-based imidazolium type ionic liquids (ILs) were designed and synthesized for bacterial killing and imaging, cell labelling and bacterial detection in blood cells. The AIE-based ILs showed antibacterial activities against both E. coli and S. aureus. The carbon chain length of substitution at the N3 position of the imidazolium cations highly affect the antibacterial properties of ILs. Due to their AIE characteristics, the ILs could selectively fluorescent image dead bacteria while killing the bacteria. The fluorescence intensity varied with the concentration of bacteria, indicating that the AIE-based ILs would be an excellent antibacterial material as well as an efficient probe for bacterial viability assay. In addition, the synthesized AIE-based ILs exhibit relatively low cytotoxicity and hemolysis rate, and therefore potential for cell labelling, as well as bacterial detection in blood cells.

Keywords: aggregation-induced emission, ionic liquids, bacterial imaging, cell labelling, bacterial detection

Suggested Citation

Shi, Jie and Wang, Mengyao and Sun, Zhe and Liu, Yangyang and Guo, Jiangna and Mao, Hailei and Yan, Feng, Aggregation-Induced Emission-Based Ionic Liquids for Bacterial Killing, Imaging, Cell Labelling and Bacterial Detection in Blood Cells (April 8, 2019). Available at SSRN: https://ssrn.com/abstract=3368390

Jie Shi (Contact Author)

Soochow University - Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application

Suzhou, 215123
China

Mengyao Wang

Soochow University - Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application

Suzhou, 215123
China

Zhe Sun

Soochow University - Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application

Suzhou, 215123
China

Yangyang Liu

Fudan University - Department of Anesthesiology and Critical Care Medicine

Shanghai, 200032
China

Jiangna Guo

Soochow University - Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application

Suzhou, 215123
China

Hailei Mao

Fudan University - Department of Anesthesiology and Critical Care Medicine

Shanghai, 200032
China

Feng Yan

Soochow University - Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application ( email )

Suzhou, 215123
China

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