Aggregation-Induced Emission-Based Ionic Liquids for Bacterial Killing, Imaging, Cell Labelling and Bacterial Detection in Blood Cells
35 Pages Posted: 8 Apr 2019 First Look: Under Review
A series of aggregation-induced emission (AIE)-based imidazolium type ionic liquids (ILs) were designed and synthesized for bacterial killing and imaging, cell labelling and bacterial detection in blood cells. The AIE-based ILs showed antibacterial activities against both E. coli and S. aureus. The carbon chain length of substitution at the N3 position of the imidazolium cations highly affect the antibacterial properties of ILs. Due to their AIE characteristics, the ILs could selectively fluorescent image dead bacteria while killing the bacteria. The fluorescence intensity varied with the concentration of bacteria, indicating that the AIE-based ILs would be an excellent antibacterial material as well as an efficient probe for bacterial viability assay. In addition, the synthesized AIE-based ILs exhibit relatively low cytotoxicity and hemolysis rate, and therefore potential for cell labelling, as well as bacterial detection in blood cells.
Keywords: aggregation-induced emission, ionic liquids, bacterial imaging, cell labelling, bacterial detection
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