lancet-header
Preprints with The Lancet is part of SSRN´s First Look, a place where journals and other research experts identify content of interest prior to publication. These preprint papers are not peer-reviewed and are posted here as part of a 12-month trial. Authors have either opted in at submission to The Lancet family of journals to post their preprints on Preprints with The Lancet, or submitted directly via SSRN. The usual SSRN checks and a Lancet-specific check for appropriateness and transparency have been applied. These papers should not be used for clinical decision making or reporting of research to a lay audience without indicating that this is preliminary research that has not been peer-reviewed. For more information see the Comment published in The Lancet, or visit The Lancet´s FAQ page, and for any feedback please contact preprints@lancet.com

Cytokine Dependent Hematopoietic Cell Linker (CLNK) Is Highly Elevated in Blood Transfusion Dependent Beta-Thalassemia Major Patients

22 Pages Posted: 13 Apr 2019

See all articles by Hussein Kadhem Al-Hakeim

Hussein Kadhem Al-Hakeim

Kufa University

Hawraa Hussein Al-Mayali

Kufa University

Michael Maes

Chulalongkorn University - Department of Psychiatry; Medical University of Plovdiv - Department of Psychiatry; Deakin University - IMPACT Strategic Research Centre

More...

Abstract

Beta-thalassemia major (β-TM) is a severe form of thalassemia caused by mutations in the β-globin gene, resulting in partial or complete deficiency of β-globin chains. This deficiency results in oxidative stress, dyserythropoiesis, and chronic anemia. Cytokine dependent hematopoietic cell linker (CLNK) belongs to the adaptor protein family and has the capacity to interact with multiple signaling proteins thereby modulating signal transduction. The aim of the present study was to examine CLNK in sera of β-TM patients and examine its association with iron overload biomarkers. Sixty β-TM patients, aged 3-12 years old and undergoing blood transfusions, and 30 healthy control children were recruited and CLNK, ferritin and iron status parameters were measured. The results showed a significant increase (p<0.001) in serum CLNK levels in β-TM patients as compared with normal controls. The increased levels of CLNK were significantly associated with increased ferritin levels. Increased CLNK levels in β-TM may be explained by reciprocal effects between immune signaling and immature erythrocytes, which, release soluble receptors and signaling molecules, including CLNK, in the blood.

Funding: No specific funding for this research. Self-funded.

Declaration of Interest: No conflict of interest.

Ethical Approval: The ethics committee of Kufa University approved this study (REC number: 1321).

Keywords: CLNK, thalassemia, ferritin, iron overload

Suggested Citation

Al-Hakeim, Hussein Kadhem and Al-Mayali, Hawraa Hussein and Maes, Michael, Cytokine Dependent Hematopoietic Cell Linker (CLNK) Is Highly Elevated in Blood Transfusion Dependent Beta-Thalassemia Major Patients (April 10, 2019). Available at SSRN: https://ssrn.com/abstract=3369783

Hussein Kadhem Al-Hakeim

Kufa University ( email )

Najaf
Iraq

Hawraa Hussein Al-Mayali

Kufa University ( email )

Najaf
Iraq

Michael Maes (Contact Author)

Chulalongkorn University - Department of Psychiatry ( email )

Bangkok
Thailand

Medical University of Plovdiv - Department of Psychiatry ( email )

Plovdiv
Bulgaria

Deakin University - IMPACT Strategic Research Centre ( email )

Geelong, Victoria 3004
Australia

Click here to go to TheLancet.com

Go to TheLancet.com

Paper statistics

Abstract Views
101
Downloads
25