In-Vitro Hepatoprotective Activity of Lindernia Madayiparense Extracts

9 Pages Posted: 30 Apr 2019

See all articles by S. Umakrithika

S. Umakrithika

Department of pharmaceutical chemistry,swamy vivekanandha college of pharmacy

P. Manimekalaib

Department of pharmacology,swamy vivekanandha college of pharmacy

R. Senthil Kumar

Department of pharmaceutical chemistry,swamy vivekanandha college of pharmacy

P. K. Manna

Annamalai University - Department of Pharmacy

K. Kannan

Annamalai University - Department of Pharmacy

Date Written: April 11, 2019

Abstract

The liver is a vital organ that functions as a focal point of metabolism and detoxification. Generally liver damage can be induced by biological factors, autoimmune diseases, action of different chemicals, such as drugs and toxic compounds, excessive consumption of alcohol and malnutrition. According to the estimate, more than 700 mono or poly-herbal preparations in the form of decoction, tincture, tablets and capsules are in clinical use as hepatoprotective. The various extracts of recently identified plant, Lindernia madayiparense were assessed for the invitro hepatoprotective activity at the first time on CCl4 induced hepatotoxic Human Liver cell lines (HEpG-2 cell line) by MTT assay method. The results revealed that CCl4 intoxicated human cell lines treated with ethanol extract showed the significant % viability (55.57%) followed by decocted extract (53.68%) in a dose dependent manner and compared to standard, Silymarin.

Keywords: Hepatoprotective, MTT, Lindernia madayiparense, HEpG-2, liver, in-vitro

Suggested Citation

Umakrithika, S. and Manimekalaib, P. and Kumar, R. Senthil and Manna, P. K. and Kannan, K., In-Vitro Hepatoprotective Activity of Lindernia Madayiparense Extracts (April 11, 2019). Available at SSRN: https://ssrn.com/abstract=3370122 or http://dx.doi.org/10.2139/ssrn.3370122

S. Umakrithika (Contact Author)

Department of pharmaceutical chemistry,swamy vivekanandha college of pharmacy ( email )

Tiruchengode
TN 637205

P. Manimekalaib

Department of pharmacology,swamy vivekanandha college of pharmacy ( email )

Tiruchengode
TN 637205
India

R. Senthil Kumar

Department of pharmaceutical chemistry,swamy vivekanandha college of pharmacy ( email )

Tiruchengode
TN 637205

P. K. Manna

Annamalai University - Department of Pharmacy ( email )

Annamalainagar
Chidambaram, Tamil Nadu 608002
India

K. Kannan

Annamalai University - Department of Pharmacy ( email )

Annamalainagar
Chidambaram, Tamil Nadu 608002
India

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