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Real-Time In-Vivo Control of Neural Membrane Potential by Electro-Ionic Modulation

38 Pages Posted: 15 Apr 2019 Sneak Peek Status: Review Complete

See all articles by Zafer Soybaş

Zafer Soybaş

TOBB University of Economics and Technology - Department of Electrical and Electronics Engineering

Sefa Şimşek

TOBB University of Economics and Technology - Department of Electrical and Electronics Engineering

F.M. Betül Erol

Hacettepe University - Faculty of Medicine

Esra N. Şimşek

TOBB University of Economics and Technology - Department of Electrical and Electronics Engineering

U. Çiya Erdoğan

TOBB University of Economics and Technology - Department of Electrical and Electronics Engineering

Büşra Şahin

TOBB University of Economics and Technology - Department of Electrical and Electronics Engineering

Merve Marçalı

Bilkent University - Institute of Materials Science and Nanotechnology

Bahattin Aydoğdu

Dicle University - Department of Pediatric Surgery

Çağlar Elbüken

Bilkent University - Institute of Materials Science and Nanotechnology

Rohat Melik

TOBB University of Economics and Technology - Department of Electrical and Electronics Engineering

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Abstract

Theoretically, by controlling neural membrane potential (Vm) in-vivo; motion, sensation, and behavior can be controlled. Until now, there was no available technique that can increase or decrease ion concentration in-vivo in real-time to change neural membrane potential. We introduce a novel method, which we coin as electro-ionic modulation (EIM), where ionic concentration around a nerve can be controlled in real-time and in-vivo. We used an interface to regulate the Ca2+ ion concentration around the sciatic nerve of a frog, thus achieved stimulation and blocking with higher resolution and lower current compared to electrical stimulation. Since EIM achieves higher controllability of Vm, it has potential to replace conventional methods used for treatment of neurological disorders and may bring a new perspective to neuromodulation techniques.

Keywords: neuromodulation, electro-ionic modulation (EIM), neural membrane potential (Vm), ion concentration control in-vivo in real-time, action potential, large and small axons, selective stimulation and blocking of nerves

Suggested Citation

Soybaş, Zafer and Şimşek, Sefa and Erol, F.M. Betül and Şimşek, Esra N. and Erdoğan, U. Çiya and Şahin, Büşra and Marçalı, Merve and Aydoğdu, Bahattin and Elbüken, Çağlar and Melik, Rohat, Real-Time In-Vivo Control of Neural Membrane Potential by Electro-Ionic Modulation (April 13, 2019). Available at SSRN: https://ssrn.com/abstract=3371411
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Zafer Soybaş

TOBB University of Economics and Technology - Department of Electrical and Electronics Engineering

Turkey

Sefa Şimşek

TOBB University of Economics and Technology - Department of Electrical and Electronics Engineering

Turkey

F.M. Betül Erol

Hacettepe University - Faculty of Medicine

Turkey

Esra N. Şimşek

TOBB University of Economics and Technology - Department of Electrical and Electronics Engineering

Turkey

U. Çiya Erdoğan

TOBB University of Economics and Technology - Department of Electrical and Electronics Engineering

Turkey

Büşra Şahin

TOBB University of Economics and Technology - Department of Electrical and Electronics Engineering

Turkey

Merve Marçalı

Bilkent University - Institute of Materials Science and Nanotechnology

Turkey

Bahattin Aydoğdu

Dicle University - Department of Pediatric Surgery

Turkey

Çağlar Elbüken

Bilkent University - Institute of Materials Science and Nanotechnology

Turkey

Rohat Melik (Contact Author)

TOBB University of Economics and Technology - Department of Electrical and Electronics Engineering ( email )

Turkey

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