The Potential Economic Role of Regenerative Therapy in the Treatment of Knee Osteoarthritis

35 Pages Posted: 17 Apr 2019

See all articles by Salvatore Russo

Salvatore Russo

Ca Foscari University of Venice

Paolo Landa

University of Exeter - Peninsula Medical School

Stefano Landi

Ca Foscari University of Venice - Department of Management

Date Written: April 2019

Abstract

Background. Osteoarthritis (OA) is a chronic and degenerative pathology that affects joints in particular hands, knees, hip and lower back. The prevalence and incidence is in continuous increase for the advanced ageing of the population and the increasing presence of risk factors such as obesity. OA burden of disease implies high care costs and has an important social impact because it limits people’s every day activities causing pain and mobility reduction.

Objectives. The aim of this work is to carry out an economic evaluation of the intra-articular (i.a.) use of the Platelet-Rich Plasma (PRP) therapy in the treatment for knee osteoarthritis. Recently the scientific literature has shown the effectiveness of this treatment. The comparator adopted is the Hyaluronic acid (HA) which represents the standard i.a. therapy. Both therapies can reduce pain, improving patient quality of life, and can help the patient to delay the joint surgery, that represents a high cost for the National Health System.

Methods. A cost-effectiveness analysis (CEA) were performed using a decision tree model. The effectiveness outcomes are reported in terms of Quality Adjusted Life Year (QALY). The costs are reported in Euro (€) currency evaluated in 2016. The adopted perspective is the Healthcare System and only direct cost have been included in the analyses. Deterministic and probabilistic sensibility analyses are reported in order to evaluate the robustness of the results and account for the different sources of uncertainty.The analyses have been carried out for three European country: Germany, Italy and France.

Results. The PRP therapy results more costly but also more effective than HA. Using a Willingness to pay thresholds of € 10,000/QALY, the PRP result the cost-effective therapy with respect to HA, for patient with moderate to severe knee OA.

Keywords: Platelet-Rich Plasma, Hyaluronic acid, cost-effectiveness analysis, Cost-Utility Analysis, Knee Osteoarthritis

JEL Classification: C63, D61, I1

Suggested Citation

Russo, Salvatore and Landa, Paolo and Landi, Stefano, The Potential Economic Role of Regenerative Therapy in the Treatment of Knee Osteoarthritis (April 2019). Department of Management, Università Ca' Foscari Venezia Working Paper No. 2, Available at SSRN: https://ssrn.com/abstract=3372848 or http://dx.doi.org/10.2139/ssrn.3372848

Salvatore Russo

Ca Foscari University of Venice ( email )

Dorsoduro 3246
Venice, Veneto 30123
Italy

Paolo Landa

University of Exeter - Peninsula Medical School ( email )

United Kingdom

Stefano Landi (Contact Author)

Ca Foscari University of Venice - Department of Management ( email )

San Giobbe, Cannaregio 873
Venice, 30121
Italy

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