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Dorsal-to-Ventral Neocortical Expansion is Physically Primed by Ventral Streaming of Early Embryonic Preplate Neurons

61 Pages Posted: 25 Apr 2019 Sneak Peek Status: Review Complete

See all articles by Kanako Saito

Kanako Saito

Nagoya University - Department of Anatomy and Cell Biology

Mayumi Okamoto

Nagoya University - Department of Anatomy and Cell Biology

Yuto Watanabe

Nagoya University - Department of Anatomy and Cell Biology

Namiko Noguchi

Nagoya University - Department of Anatomy and Cell Biology

Arata Nagasaka

Nagoya University - Department of Anatomy and Cell Biology

Yuta Nishina

Nagoya University - Department of Anatomy and Cell Biology

Tomoyasu Shinoda

Nagoya University - Department of Anatomy and Cell Biology

Akira Sakakibara

Chubu University - College of Life and Health Sciences

Takaki Miyata

Nagoya University - Department of Anatomy and Cell Biology

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Abstract

Mammalian neocortex exhibits a disproportionally “luxurious” representation of somatotopies in its lateral region, which depends on dorsal-to-ventral expansion of the pallium during development. Despite recent studies elucidating the molecular mechanisms underlying the cortical arealization/patterning, we know very little about how the cortex expands ventrally and the nature of the underlying force-generating events. We found that neurons born earliest (at embryonic day 10 [E10]) in the mouse pallium migrated ventrally and then extended corticofugal axons, which together formed a morphogenetic flow of the preplate that persists until E13. These neurons exerted pulling and pushing forces at the process and the soma, respectively. Ablation of these E10-born neurons attenuated both deflection of radial glial fibers (by E13) and extension of the cortical plate (by E14), which should occur ventrally, and subsequently shrank the postnatal neocortical map dorsally. This previously unrecognized preplate stream physically primes neocortical expansion and somatotopic map formation.

Keywords: neocortex, somatotopy, protomap, radial glia, preplate, subplate, tangential migration, mechanical factor, axonal traction

Suggested Citation

Saito, Kanako and Okamoto, Mayumi and Watanabe, Yuto and Noguchi, Namiko and Nagasaka, Arata and Nishina, Yuta and Shinoda, Tomoyasu and Sakakibara, Akira and Miyata, Takaki, Dorsal-to-Ventral Neocortical Expansion is Physically Primed by Ventral Streaming of Early Embryonic Preplate Neurons (April 24, 2019). Available at SSRN: https://ssrn.com/abstract=3377361 or http://dx.doi.org/10.2139/ssrn.3377361
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Kanako Saito

Nagoya University - Department of Anatomy and Cell Biology ( email )

Japan

Mayumi Okamoto

Nagoya University - Department of Anatomy and Cell Biology ( email )

Japan

Yuto Watanabe

Nagoya University - Department of Anatomy and Cell Biology ( email )

Japan

Namiko Noguchi

Nagoya University - Department of Anatomy and Cell Biology ( email )

Japan

Arata Nagasaka

Nagoya University - Department of Anatomy and Cell Biology ( email )

Japan

Yuta Nishina

Nagoya University - Department of Anatomy and Cell Biology ( email )

Japan

Tomoyasu Shinoda

Nagoya University - Department of Anatomy and Cell Biology ( email )

Japan

Akira Sakakibara

Chubu University - College of Life and Health Sciences

Kasugai, Aichi
Japan

Takaki Miyata (Contact Author)

Nagoya University - Department of Anatomy and Cell Biology ( email )

Japan

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