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A Kind of IgE-Independent Chronic Urticarial Mediated by MRGPRX2

24 Pages Posted: 4 May 2019

See all articles by Delu Che

Delu Che

Xi'an Jiaotong University (XJTU) - School of Pharmacy

Tao Zhang

Xi'an Jiaotong University (XJTU) - School of Pharmacy

Jue Wang

Xi'an Jiaotong University (XJTU) - School of Pharmacy

Jiao Cao

Xi'an Jiaotong University (XJTU) - School of Pharmacy

Yuanyuan Ding

Xi'an Jiaotong University (XJTU) - School of Pharmacy

Tianxiao Zhang

Xi'an Jiaotong University (XJTU)

Xiaopeng Wang

Xi'an Jiaotong University (XJTU) - Department of Dermatology

Jingang An

Xi'an Jiaotong University (XJTU) - Department of Dermatology

Lei Zhang

Xi'an Jiaotong University (XJTU) - Second Affiliated Hospital

Yan Geng

Xi'an Jiaotong University (XJTU) - Second Affiliated Hospital

Yajing Hou

Xi'an Jiaotong University (XJTU) - School of Pharmacy

Yongjing Zhang

Xi'an Jiaotong University (XJTU) - School of Pharmacy

Rui Liu

Xi'an Jiaotong University (XJTU) - School of Pharmacy

Songmei Geng

Xi'an Jiaotong University (XJTU) - Department of Dermatology

Langchong He

Xi'an Jiaotong University (XJTU) - School of Pharmacy

More...

Abstract

Concentration of serum substance P (SP) were confirmed higher in chronic urticaria (CU) patients. Subsequently, SP was verified to induce pseudo-allergic reactions via MRGPRX2. To confirm that IgE-independent CU was connected with MRGPRX2, a single-center, case-control study was adopted. A total of 353 residual peripheral blood samples from clinical examinations were collected, including the patient groups (150 CU specimen, 68 acute urticarial (AU) specimen, and 135 control specimen of healthy people who underwent physical examinations. Transcripts of MRGPRX2 were detected by RT-PCR and recorded as log copy number (LCN), while serum SP was detected using ELISA Kits. Data analyses were performed by R project software package. The results showed that MRGPRX2 expressed in peripheral blood basophils and levels of MRGPRX2 transcripts, as well as serum SP concentration, were higher in the CU group. IgE levels in these patients were particularly low and the scores of wheal and itch were lighter. MRGPRX2 receptor mediates a kind of CU which is IgE-independent.

Trial Registry Number: This study was registered at Chinese Clinical Trail Registry, and the registration number is ChiCTR-DDD-17013003.

Funding Statement: This work was supported by the National Natural Science Foundation of China (Grant Number: 81230079 and 81872837).

Declaration of Interests: The authors declare no competing financial interests.

Ethics Approval Statement: The ethical approval was approved by Ethics Committee at Xi’an Jiaotong University and conformed to the ethical standard. All the specimen in this study had signed informed consent.

Keywords: Chronic urticarial, Substance P, MRGPRX2, Peripheral blood basophils, pseudo-allergic reactions

Suggested Citation

Che, Delu and Zhang, Tao and Wang, Jue and Cao, Jiao and Ding, Yuanyuan and Zhang, Tianxiao and Wang, Xiaopeng and An, Jingang and Zhang, Lei and Geng, Yan and Hou, Yajing and Zhang, Yongjing and Liu, Rui and Geng, Songmei and He, Langchong, A Kind of IgE-Independent Chronic Urticarial Mediated by MRGPRX2 (May 1, 2019). Available at SSRN: https://ssrn.com/abstract=3381129

Delu Che

Xi'an Jiaotong University (XJTU) - School of Pharmacy

Xi'an
China

Tao Zhang

Xi'an Jiaotong University (XJTU) - School of Pharmacy

Xi'an
China

Jue Wang

Xi'an Jiaotong University (XJTU) - School of Pharmacy

Xi'an
China

Jiao Cao

Xi'an Jiaotong University (XJTU) - School of Pharmacy

Xi'an
China

Yuanyuan Ding

Xi'an Jiaotong University (XJTU) - School of Pharmacy

Xi'an
China

Tianxiao Zhang

Xi'an Jiaotong University (XJTU)

26 Xianning W Rd.
Xi'an Jiao Tong University
Xi'an, Shaanxi 710049
China

Xiaopeng Wang

Xi'an Jiaotong University (XJTU) - Department of Dermatology

China

Jingang An

Xi'an Jiaotong University (XJTU) - Department of Dermatology

China

Lei Zhang

Xi'an Jiaotong University (XJTU) - Second Affiliated Hospital

China

Yan Geng

Xi'an Jiaotong University (XJTU) - Second Affiliated Hospital

China

Yajing Hou

Xi'an Jiaotong University (XJTU) - School of Pharmacy

Xi'an
China

Yongjing Zhang

Xi'an Jiaotong University (XJTU) - School of Pharmacy

Xi'an
China

Rui Liu

Xi'an Jiaotong University (XJTU) - School of Pharmacy

Xi'an
China

Songmei Geng

Xi'an Jiaotong University (XJTU) - Department of Dermatology ( email )

China

Langchong He (Contact Author)

Xi'an Jiaotong University (XJTU) - School of Pharmacy ( email )

Xi'an
China

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