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Adaptive in vivo Device for Theranostics of Inflammation by Monitoring of Cytokine Interferon-γ and Its Triggered Aspirin Release

33 Pages Posted: 16 May 2019 Publication Status: Accepted

See all articles by Chaomin Cao

Chaomin Cao

Central China Normal University - International Joint Research Center for Intelligent Biosensor Technology and Health

Ronghua Jin

Xi'an Jiaotong University (XJTU), School of Chemical Engineering and Technology, Institute of Polymer Science in Chemical Engineering, Shanxi Key Laboratory of Energy Chemical Process Intensification

Hui Wei

Central China Normal University - International Joint Research Center for Intelligent Biosensor Technology and Health

Zhongning Liu

Peking University - Department of Prosthodontics; National Clinical Research Center for Oral Diseases; National Engineering Laboratory for Digital and Material, Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology

Shengnan Ni

Central China Normal University - International Joint Research Center for Intelligent Biosensor Technology and Health

Xin Chen

Xi'an Jiaotong University (XJTU), School of Chemical Engineering and Technology, Institute of Polymer Science in Chemical Engineering, Shanxi Key Laboratory of Energy Chemical Process Intensification

Howard A. Young

National Cancer Institute at Frederick, Cancer and Inflammation Program, Center for Cancer Research

Guojun Liu

Government of the Commonwealth of Australia - Australian Nuclear Science and Technology Organisation

Guozhen Liu

University of New South Wales (UNSW), Faculty of Engineering, Graduate School of Biomedical Engineering, ARC Centre of Excellent for Nanoscale Bipphotonics

Abstract

Cytokines mediate and control immune and inflammatory responses. Complex interactions exist between cytokines, inflammation and the adaptive responses in maintaining homeostasis, health, and well being. On-demand, local delivery of anti-inflammatory drug molecules to target tissues provides a means for effective drug dosing while reducing the adverse effects of systemic drug delivery. This work demonstrates a proof-of-concept theranostic approach for inflammation based on analyte-kissing induced signaling, whereby a drug (in this report, aspirin) can be released upon detection of a target level of a proinfammatory cytokine(i.e. Interferon-γ (IFN-γ)) in real time. The structure-switching aptamer based biosensor described here is capable of quantitatively and dynamically detecting IFN-γ both in vitro and in vivo with a sensitivity of 10 pg mL-1. Moreover, the released aspirin triggered by the inflammatory cytokine IFN-γ is able to inhibit inflammation in the inflammatory rat model, and the releasing of aspirin can be quantitatively controlled. Herein research provides a novel and promising strategy for in vivo detection of proinflammatory cytokines and the subsequent therapeutic delivery of anti-inflammatory molecules. This universal theranostic platform is expected to achieve great potentials on personalized medicine towards treatment of various of diseases and health conditions.

Keywords: cytokines, adaptive in vivo device, structure-switching aptamers, theranostics, inflammation, aspirin

Suggested Citation

Cao, Chaomin and Jin, Ronghua and Wei, Hui and Liu, Zhongning and Ni, Shengnan and Chen, Xin and Young, Howard A. and Liu, Guojun and Liu, Guozhen, Adaptive in vivo Device for Theranostics of Inflammation by Monitoring of Cytokine Interferon-γ and Its Triggered Aspirin Release (May 14, 2019). Available at SSRN: https://ssrn.com/abstract=3387641 or http://dx.doi.org/10.2139/ssrn.3387641

Chaomin Cao

Central China Normal University - International Joint Research Center for Intelligent Biosensor Technology and Health

Wuhan
China

Ronghua Jin

Xi'an Jiaotong University (XJTU), School of Chemical Engineering and Technology, Institute of Polymer Science in Chemical Engineering, Shanxi Key Laboratory of Energy Chemical Process Intensification

Xi'an
China

Hui Wei

Central China Normal University - International Joint Research Center for Intelligent Biosensor Technology and Health

Wuhan
China

Zhongning Liu

Peking University - Department of Prosthodontics

Beijing
China

National Clinical Research Center for Oral Diseases

Shanghai
China

National Engineering Laboratory for Digital and Material, Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology

Beijing
China

Shengnan Ni

Central China Normal University - International Joint Research Center for Intelligent Biosensor Technology and Health

Wuhan
China

Xin Chen

Xi'an Jiaotong University (XJTU), School of Chemical Engineering and Technology, Institute of Polymer Science in Chemical Engineering, Shanxi Key Laboratory of Energy Chemical Process Intensification

Xi'an
China

Howard A. Young

National Cancer Institute at Frederick, Cancer and Inflammation Program, Center for Cancer Research

Frederick, MD
United States

Guojun Liu

Government of the Commonwealth of Australia - Australian Nuclear Science and Technology Organisation

New South Wales
Australia

Guozhen Liu (Contact Author)

University of New South Wales (UNSW), Faculty of Engineering, Graduate School of Biomedical Engineering, ARC Centre of Excellent for Nanoscale Bipphotonics ( email )

Sydney
Australia

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