Global, Regional, and National Burden of Hodgkin Lymphoma from 1990 to 2017: Estimates from the 2017 Global Burden of Disease Study
21 Pages Posted: 2 Jun 2019More...
Background: Hodgkin lymphoma (HL) is an uncommon B-cell lymphoma. We assessed the global, regional, and national burden of HL from 1990 to 2017, by gender, age, and social demographic index (SDI).
Methods: Data on HL, including morbidity, mortality, and disability adjusted life-years (DALY), from 1990 to 2017, was obtained from the 2017 Global Burden of Disease study. Estimated annual percentage changes (EAPCs) were calculated to assess morbidity, mortality, and DALY trends.
Results: HL incidences increased by 38.66%, from 72937 in 1990 to 101133 in 2017, while the age-standardized incidence rate (ASIR) decreased by 0·51% (95% CI, -0·57% - -0·45%) yearly. ASIR in high SDI (EAPC=0·19, 95% CI, 0·02 - -0·36) and high-middle SDI (EAPC = 0·84, 95% CI, 0·6 - 1·08) regions increased. Morbidity showed a bimodal distribution with peak values in patients aged 20-39 years and patients aged 60 years or higher. Number of deaths decreased by 9.42%, from 35,946 in 1990 to 32,560 in 2017. The age-standardized death rate decreased by 2·36% (95% CI, -2·43%--2·30%) per year.
Interpretation: Globally, incidence, mortality, and DALY rate of HL have been decreasing. Nevertheless, morbidity in the high SDI and the high-middle SDI regions was higher and has been increasing, indicating the need for the establishment of more targeted and specific strategies in high SDI countries to prevent the increase of HL incidence.
Funding: National Natural Science Foundation, People's Republic of China (No. 81471670).
Declaration of Interest: The authors report no conflicts of interest.
Ethical Approval: This study was approved by The First Affiliated Hospital, College of Medicine, Zhejiang University. The data released from the Global Health Data Exchange query did not require informed patient consent.
Keywords: global burden of disease, Hodgkin lymphoma, incidence, death, disability adjusted life-years
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