lancet-header
Preprints with The Lancet is part of SSRN´s First Look, a place where journals and other research experts identify content of interest prior to publication. These preprint papers are not peer-reviewed and are posted here as part of a 12-month trial. Authors have either opted in at submission to The Lancet family of journals to post their preprints on Preprints with The Lancet, or submitted directly via SSRN. The usual SSRN checks and a Lancet-specific check for appropriateness and transparency have been applied. These papers should not be used for clinical decision making or reporting of research to a lay audience without indicating that this is preliminary research that has not been peer-reviewed. For more information see the Comment published in The Lancet, or visit The Lancet´s FAQ page, and for any feedback please contact preprints@lancet.com

Global, Regional, and National Burden of Hodgkin Lymphoma from 1990 to 2017: Estimates from the 2017 Global Burden of Disease Study

21 Pages Posted: 2 Jun 2019

See all articles by Linghui Zhou

Linghui Zhou

Xi'an Jiaotong University (XJTU) - Department of Oncology

Yujiao Deng

Zhejiang University - Department of Breast Surgery; Xi'an Jiaotong University (XJTU) - Department of Oncology

Na Li

Zhejiang University - Department of Breast Surgery; Xi'an Jiaotong University (XJTU) - Department of Oncology

Yi Zheng

Zhejiang University - Department of Breast Surgery

Tian Tian

Xi'an Jiaotong University (XJTU) - Department of Oncology

Zhen Zhai

Xi'an Jiaotong University (XJTU) - Department of Oncology

Si Yang

Zhejiang University - Department of Breast Surgery; Xi'an Jiaotong University (XJTU) - Department of Oncology

Qian Hao

Xi'an Jiaotong University (XJTU) - Department of Oncology

Ying Wu

Xi'an Jiaotong University (XJTU) - Department of Oncology

Dingli Song

Xi'an Jiaotong University (XJTU) - Department of Oncology

Dai Zhang

Xi'an Jiaotong University (XJTU) - Department of Oncology

Jun Lyu

Xi'an Jiaotong University (XJTU) - Clinical Research Center; Xi'an Jiaotong University (XJTU) - School of Public Health; Institute of Evidence-Based Medicine and Knowledge Translation

Zhi-Jun Dai

Zhejiang University - Department of Breast Surgery; Xi'an Jiaotong University (XJTU) - Department of Oncology

More...

Abstract

Background: Hodgkin lymphoma (HL) is an uncommon B-cell lymphoma. We assessed the global, regional, and national burden of HL from 1990 to 2017, by gender, age, and social demographic index (SDI).

Methods: Data on HL, including morbidity, mortality, and disability adjusted life-years (DALY), from 1990 to 2017, was obtained from the 2017 Global Burden of Disease study. Estimated annual percentage changes (EAPCs) were calculated to assess morbidity, mortality, and DALY trends.

Results: HL incidences increased by 38.66%, from 72937 in 1990 to 101133 in 2017, while the age-standardized incidence rate (ASIR) decreased by 0·51% (95% CI, -0·57% - -0·45%) yearly. ASIR in high SDI (EAPC=0·19, 95% CI, 0·02 - -0·36) and high-middle SDI (EAPC = 0·84, 95% CI, 0·6 - 1·08) regions increased. Morbidity showed a bimodal distribution with peak values in patients aged 20-39 years and patients aged 60 years or higher. Number of deaths decreased by 9.42%, from 35,946 in 1990 to 32,560 in 2017. The age-standardized death rate decreased by 2·36% (95% CI, -2·43%--2·30%) per year.

Interpretation: Globally, incidence, mortality, and DALY rate of HL have been decreasing. Nevertheless, morbidity in the high SDI and the high-middle SDI regions was higher and has been increasing, indicating the need for the establishment of more targeted and specific strategies in high SDI countries to prevent the increase of HL incidence.

Funding: National Natural Science Foundation, People's Republic of China (No. 81471670).

Declaration of Interest: The authors report no conflicts of interest.

Ethical Approval: This study was approved by The First Affiliated Hospital, College of Medicine, Zhejiang University. The data released from the Global Health Data Exchange query did not require informed patient consent.

Keywords: global burden of disease, Hodgkin lymphoma, incidence, death, disability adjusted life-years

Suggested Citation

Zhou, Linghui and Deng, Yujiao and Li, Na and Zheng, Yi and Tian, Tian and Zhai, Zhen and Yang, Si and Hao, Qian and Wu, Ying and Song, Dingli and Zhang, Dai and Lyu, Jun and Dai, Zhi-Jun, Global, Regional, and National Burden of Hodgkin Lymphoma from 1990 to 2017: Estimates from the 2017 Global Burden of Disease Study (May 29, 2019). Available at SSRN: https://ssrn.com/abstract=3396038

Linghui Zhou

Xi'an Jiaotong University (XJTU) - Department of Oncology

Xi'an
China

Yujiao Deng

Zhejiang University - Department of Breast Surgery

Hangzhou
China

Xi'an Jiaotong University (XJTU) - Department of Oncology

Xi'an
China

Na Li

Zhejiang University - Department of Breast Surgery

Hangzhou
China

Xi'an Jiaotong University (XJTU) - Department of Oncology

Xi'an
China

Yi Zheng

Zhejiang University - Department of Breast Surgery

Hangzhou
China

Tian Tian

Xi'an Jiaotong University (XJTU) - Department of Oncology

Xi'an
China

Zhen Zhai

Xi'an Jiaotong University (XJTU) - Department of Oncology

Xi'an
China

Si Yang

Zhejiang University - Department of Breast Surgery

Hangzhou
China

Xi'an Jiaotong University (XJTU) - Department of Oncology

Xi'an
China

Qian Hao

Xi'an Jiaotong University (XJTU) - Department of Oncology

Xi'an
China

Ying Wu

Xi'an Jiaotong University (XJTU) - Department of Oncology

Xi'an
China

Dingli Song

Xi'an Jiaotong University (XJTU) - Department of Oncology

Xi'An
China

Dai Zhang

Xi'an Jiaotong University (XJTU) - Department of Oncology

Xi'an
China

Jun Lyu

Xi'an Jiaotong University (XJTU) - Clinical Research Center ( email )

26 Xianning W Rd.
Xi'an, Shaanxi 710049
China

Xi'an Jiaotong University (XJTU) - School of Public Health ( email )

China

Institute of Evidence-Based Medicine and Knowledge Translation ( email )

China

Zhi-Jun Dai (Contact Author)

Zhejiang University - Department of Breast Surgery ( email )

Hangzhou
China

Xi'an Jiaotong University (XJTU) - Department of Oncology ( email )

Xi'an
China

Click here to go to TheLancet.com

Go to TheLancet.com

Paper statistics

Abstract Views
41
Downloads
6